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您的检索式：作者名="Alain Chevailler"
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| 1 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 2 | FibroMeters:诊断肝纤维化的血液学检测指标组合(英文)显示文摘FibroMeters是具有多项特异性的诊断肝纤维化的血液学检测指标组合,其3个主要诊断目标为显著肝纤维化、肝硬化以及肝纤维化的定量,并由专业系统针对不同病因进行调整从而保证获得准确的结果。因此,主要存在 6 种不同的 FibroMeters:即针对肝纤维化的3种主要病因慢性病毒性肝炎、酒精性肝病和非酒精性脂肪性肝病的肝纤维化分期和肝纤维化定量。以肝组织病理学方法诊断肝纤维化程度进行对照,FibroMeters 表现出非常高的诊断准确率,是惟一能100%正确区分丙型肝炎患者不伴有肝纤维化或伴有肝硬化的检测方法。在适用性方面,FibroMeters 对于显著肝纤维化的 90%预测值高于其他血清学检测方法。使用包括 7 类内容在内的详细的肝纤维化分期方法,87%的丙型肝炎患者可以获得准确的肝纤维化分期。在实际工作条件下,FibroMeters 重复性高于肝组织病理结果,也高于超声弹性检测。因诊断性能表现非常稳定,FibroMeters 在不同的中心都是稳健的检测方法。目前可选择的检测有:针对肝硬化诊断的 CirrhoMeter,在一项丙型肝炎肝硬化患者的队列中其诊断准确率为 93%(受试者工作特征曲线下面积:0.92),阳性预测值为 100%;针对肝纤维化定量检测的QuantiMeter,是惟一能通过无创方法直接量化肝纤维化程度的手段,对于随访肝硬化及其临床相关事件可能特别有用。除HCV 感染外,FibroMeters对HBV或HIV同时感染患者诊断准确率高,尤其是对酒精性肝病或非酒精性脂肪肝患者,FibroMeters有较高的诊断准确率(对于显著纤维化,受试者工作特征曲线下面积分别为0.96和0.94)。 | Paul Calès Jérme Boursier Frédéric Oberti Isabelle Hubert Yves Gallois Marie Christine Rousselet Valérie Moal Laurent Macchi Alain Chevailler Julien Chaigneau Gilles Hunault | 2013 | 传染病信息2013，26，3： | 0 |
| 3 | Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation显示文摘Basophils are rare granulocytes.Despite representing only~0.5%of all leukocytes,basophils have several important physiological functions.1,2 Although basophils lack the classic features of professional antigen-presenting cells,3–7 through the secretion of cytokines,they orient the immune response by polarizing Th2 differentiation and supporting B-cell differentiation and class switching.Basophils are also critical for mediating protection against helminth infection.1,2,8,9 Basophils receive activation signals from diverse sources.It is well recognized that cytokines such as IL-3,granulocyte–macrophage colony-stimulating factor(GM-CSF),thymic stromal lymphopoietin(TSLP)and IL-33;various toll-like receptor ligands;allergen-bound IgE provide activation signals to basophils and induce the release of inflammatory mediators.10–15 In addition,several reports have also demonstrated the existence of anti-IgE autoantibodies that possess the capacity to induce basophil activation in patients with chronic spontaneous urticaria(CSU),atopic or non-atopic asthma or autoimmune disease.16–21 However,isolation and functional exploration of such anti-IgE IgG autoantibodies from either healthy donors or patients have not been attempted yet.By using a pooled normal IgG preparation from healthy donors,specifically intravenous immunoglobulin G(IVIG)22 that represents the complete IgG repertoire of a normal individual,we attempted to address this outstanding question in the field. | Caroline Galeotti Anupama Karnam Jordan D.Dimitrov Alain Chevailler Srini V.Kaveri Jagadeesh Bayry | 2020 | Cellular & Molecular Immunology2020，17，4： | 0 |
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