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| 1 | Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma显示文摘Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically. | Akiko Tomonari Akio Katanuma Tomoaki Matsumori Hajime Yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki Takahashi Toshiya Shinohara Hiroyuki Maguchi | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 2 | Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version显示文摘 | Toshirou Nishida Seiichi Hirota Akio Yanagisawa Yoshinori Sugino Manabu Minami Yoshitaka Yamamura Yoshihide Otani Yasuhiro Shimada Fumiaki Takahashi Tetsuro Kubota | 2008 | International Journal of Clinical Oncology2008，，5： | 2 |
| 3 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 4 | Rotational osteotomy at the Diaphysis of Radius in the Treatment of congenital radioulnar synostosis显示文摘 | Michiyo fujimoto Hiroyuki kato akio minami | 2005 | J pediatr Orthop2005，，25： | 1 |
| 5 | Rotational osteotomy at the Diaphysis of Radius in the Treatment of congenital radioulnar synostosis显示文摘 | Michiyo fujimoto Hiroyuki kato Akio Minami | 2005 | J pediatr Orthop2005，，25： | 1 |
| 6 | The Effect of Transforming Growth Factor-β1 on Intraosseous Healing of Flexor Tendon Autograft Replacement of Anterior Cruciate Ligament in Dogs显示文摘 | Shuji Yamazaki Kazunori Yasuda Fumihisa Tomita Harukazu Tohyama Akio Minami | 2005 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2005，，9： | 1 |
| 7 | Carbohydrate analysis by a phenol–sulfuric acid method in microplate format显示文摘 | Tatsuya Masuko Akio Minami Norimasa Iwasaki Tokifumi Majima Shin-Ichiro Nishimura Yuan C. Lee | 2004 | Analytical Biochemistry2004，，1： | 1 |
| 8 | Impact of deep extensor muscle-preserving approach on clinical outcome of laminoplasty for cervical spondylotic myelopathy: comparative cohort study显示文摘 | Yoshihisa Kotani Kuniyoshi Abumi Manabu Ito Hideki Sudo Masahiko Takahata Ken Nagahama Akira Iwata Akio Minami | 2012 | European Spine Journal2012，，8： | 1 |
| 9 | Carbohydrate analysis by a phenol-sulfuric acid method in microplate format 显示文摘 | Tatsuya Masuko Akio Minami Norimasa lwasaki | 2005 | Analytical Biochemistry2005，339，1： | 1 |
| 10 | Carbohydrate analysis by a phenol-sulfuric acid method in microplate format显示文摘 | Tatsuya Masuko Akio Minami Norimasa Iwasaki | 2005 | Analytical Biochemistry2005，339，1： | 1 |
| 11 | Minimum 2-year outcome of cervical laminoplasty with deep extensor muscle-preserving approach: impact on cervical spine function and quality of life显示文摘 | Yoshihisa Kotani Kuniyoshi Abumi Manabu Ito Hideki Sudo Masahiko Takahata Shigeki Ohshima Yoshihiro Hojo Akio Minami | 2009 | European Spine Journal2009，，5： | 1 |
| 12 | The Effect of Transforming Growth Factor-β1 on Intraosseous Healing of Flexor Tendon Autograft Replacement of Anterior Cruciate Ligament in Dogs显示文摘 | Shuji Yamazaki Kazunori Yasuda Fumihisa Tomita Harukazu Tohyama Akio Minami | 2005 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2005，，9： | 1 |
| 13 | Clinical Results and Complications of Circumferential Spinal Cord Decompression Through a Single Posterior Approach for Thoracic Myelopathy Caused by Ossification of Posterior Longitudinal Ligament显示文摘 | Masahiko Takahata Manabu Ito Kuniyoshi Abumi Yoshihisa Kotani Hideki Sudo Akio Minami | 2008 | Spine2008，，11： | 1 |
| 14 | Ulnar shortening for triangular fibrocartilage complex tears associated with ulnar positive variance显示文摘 | Akio Minami Hiroyuki Kato | 1998 | Journal of Hand Surgery1998，，5： | 1 |
| 15 | Chitosan-RGDSGGC conjugate as scaffold material for musculoskeletal tissue engineering 显示文摘 | Tatsuya Masuko Norimasa Iwasaki Shintaro Yamane Tadanao Funakoshi Tokifumi Majima Akio Minami Noriko Ohsuga Takashi Ohta Shin-Ichiro Nishimura | 2005 | Biomaterials2005，，26： | 1 |
| 16 | Rotationl osteotomy at the diaphysis of the radius in the treatment of congenital radilulnar synotosis显示文摘 | Michiyo Fujimoto Hiroyuki Kato Akio Minami | 2005 | J Pediatr Orthop2005，25，5： | 1 |
| 17 | Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering显示文摘 | Shintaro Yamane Norimasa Iwasaki Tokifumi Majima Tadanao Funakoshi Tatsuya Masuko Kazuo Harada Akio Minami Kenji Monde Shin-ichiro Nishimura | 2004 | Biomaterials2004，，6： | 1 |
| 18 | Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy显示文摘Hepar lobatum carcinomatosum (HLC) is defined as an acquired hepatic deformity consisting of an irregularly lobulated hepatic contour caused by intravascular infiltration of metastatic carcinoma. To date, only nine cases of HLC have been reported in the literature. We report a case of a 68-year-old woman showing hepatic metastasis of breast carcinoma in radiologically unidentified form. Initially, she received left partial mastectomy for breast cancer but solid hepatic metastases were identified in S2 and S6, 9 mo after surgery. Then, they responded to chemotherapy and radiologically disappeared. After radiological disappearance of the liver tumors, the patient's blood chemistry showed abnormal liver function. A CT scan demonstrated heterogeneous enhancement effect in the liver in the late phase,suggesting uneven hepatic blood supply. Hepatic deformity was not obvious. Laparoscopy revealed a slightly deformed liver surface with multiple indentations and shallow linear depressions. Furthermore, a wide scar was observed on the surface of S2 possibly at the site where the metastatic tumor existed before chemotherapy. Liver biopsy from the wide scar lesion showed intraportal tumor thrombi with desmoplastic change. Because of its similarity to the histology of the original breast cancer, we concluded that the hepatic functional abnormalities and slightly deformed liver surface were derived from the circulatory disturbance caused by microscopic tumor thrombi. Besides, since the wide scar was located at the site of the pre-existing tumor,it is probable that chemotherapy was an important cause of fibrous scarring as a result of tumor regression. These morphologic findings are compatible with those of HLC.Laparoscopy-assisted liver biopsy was useful to make definite diagnosis, even though the hepatic deformity was radiologically undetectable. | Tomoki Nakajima Satoru Sekoguchi Taichirou Nishikawa Hidetaka Takashima Tadashi Watanabe Masahito Minami Yoshito Itoh Naruhiko Mizuta Hiroo Nakajima Takeshi Mazaki Akio Yanagisawa Takeshi Okanoue | 2005 | World Journal of Gastroenterology2005，11，15： | 0 |
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