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| 1 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 2 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 3 | Development of tailored TiO_2 mesocrystals for solar driven photocatalysis显示文摘Ordered metal oxides superstructures have attracted much more attention in the fields of fuel generation and environmental purification owing to their unique physiochemical characteristics such as large surface area, fine pore structure, efficient electronic mobility, and good stability. Very recently, TiO_2mesocrystals(TMCs) having superstructures self-assembled by TiO_2 nanoparticle building blocks, are of considerable interest in current research and application ranging from UV to visible light attributed to their efficient charge separation and superior photocatalytic activity. In this review, we describe the common procedures to prepare unique TMCs and overview of recent developments of TMCs during last 3 years, especially the structure-related or electronic-effected mechanism in photocatalytic reaction. Further, we introduce the characterization and fundamental properties of modified TMCs by the means of single-particle fluorescence microscopy for unraveling the charge transport and photocatalytic properties of individual TMCs and time-resolved diffuse reflectance spectroscopy(TDR) for monitoring the charge transfer dynamics. Finally, various aspects on TMCs are discussed for the future developments of energy and environmental fields. | Peng Zhang Mamoru Fujitsuka Tetsuro Majima | 2016 | Journal of Energy Chemistry2016，25，6： | 2 |
| 4 | Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis显示文摘 | Kosaku Nitta Takashi Akiba Koichi Suzuki Keiko Uchida Ryo-Ichiro Watanabe Kazuhiro Majima Takanao Aoki Hiroshi Nihei | 2004 | American Journal of Kidney Diseases2004，，4： | 2 |
| 5 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 6 | Stimuli through Toll-like receptor (TLR) 3 and 9 affect human chorionic gonadotropin (hCG) production in a choriocarcinoma cell line显示文摘 | Komine-Aizawa S Majima H Yoshida-Noro C | 2008 | J Obstet Gynaecol Res2008，34，2： | 1 |
| 7 | Decreased bone mineral density at the distal radius,but not at the lumbar spine or the femoral neck,in Japanese type 2 diabetic patients显示文摘 | Majima T Komatsu Y Yamada T | 2005 | Osteoporos Int2005，16，8： | 1 |
| 8 | Sequence andlysis of the genome of Bombyx mori nucleoplly-hedrovirus Journal of general 显示文摘 | Sumiko Gomi Kei Majima Susumu Maeda | 1999 | Virology1999，80，： | 1 |
| 9 | Effect of Si and Al Content on Core Loss in Fe-Si-Al Powder Cores显示文摘 | Yanagimoto K Majima K Sunada S | 2004 | IEEE Trans Magn2004，40，3： | 1 |
| 10 | Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan,collagen type Ⅱ,and collagenase显示文摘 | Majima T Marchuk LL Sciore P | | 0，，4： | 1 |
| 11 | Performance val- idation of a hybrid ventilation strategy comprising longitudinal and point ventilation by a fire experiment using a model-scale tunnel 显示文摘 | Futoshi Tanaka Shohei Majima Masahiro Kato | 2015 | Fire Safety Journal2015，71，： | 1 |
| 12 | Application oftissue engineered techniques for rotator cuff regeneration using a chitesan based hyaluronan hybrid fiber scaffold 显示文摘 | FunakoshiT Majima T lwasaki N | 2005 | Am J Sports Med2005，33，8： | 1 |
| 13 | The bioleaching of chalcopyrite in ferric sulfate 显示文摘 | HIRATO T MAJIMA H AWAKURA Y | 1987 | Metall Mater Trans1987，18，： | 1 |
| 14 | Cyclooxygense-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants显示文摘 | Majima M Hayashi I Muramatsu M | 2000 | Br J Pharmacol2000，130，3： | 1 |
| 15 | Detecting circulating cancer cells using reverse transcriptase-polymerase chain reaction for cytokeratin mRNA in peripheral blood from patients with gastric cancer显示文摘 | Majima T Ichikura T Takayama E | 2000 | Jpn J Clin Oncol2000，30，： | 1 |
| 16 | Mutation of Kras but not p53 genes in biliary duct and pancreatic duct carcinoma induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl)amine 显示文摘 | Majima T Tsujiuchi T Tsutsumi M | 1997 | Cancer Lett1997，118，： | 1 |
| 17 | Effects of local hypothermia on uveal blood flow and postoperative inflammation in vitrectomy显示文摘 | Tamai K Majima A Yan C | 1995 | Jpn J Ophthalmol1995，39，11： | 1 |
| 18 | Compressive compared with tensile loading of medial collateral ligament sear invitro uniquely in- fluences mRNA levels for aggrecan, collagen type Ⅱ, and coUagena- se显示文摘 | Majima T Marchuk LL Sciore P | 2000 | J Orthop Res2000，18，4： | 1 |
| 19 | Facilitation of renal kallikrein kinin system prevents the development of hypertension by inhibition of sodium retention显示文摘 | Majima M Hayashi I Fujita T | 1999 | Immunopharmacology1999，44，： | 1 |
| 20 | Rotator cuff regeneration using chitin fabric an twellular matrix显示文摘 | Funakoshi T Majima T Suenaga N | 2006 | Shoulder Elbow Surg2006，15，1： | 1 |
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