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| 1 | Formalin fixation on HER-2 and PD-L1 expression in gastric cancer:A pilot analysis using the same surgical specimens with different fixation times显示文摘BACKGROUND The needs for human epidermal growth factor receptor 2(HER-2) and/or programmed death-ligand 1(PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized, most of the evidence regarding the fixation duration or type of fixing solution are based on breast cancer.AIM To investigate the real effects of fixation conditions on HER-2 testing or PD-L1 testing for gastric cancer using gastrectomy specimens.METHODS Thirty-two patients who underwent gastrectomy for gastric cancer were enrolled.Their resected specimens were each divided into four pieces and fixed in four strictly controlled different durations(6 h, 24 h, and 48 h, and 1 wk) by 10%formalin(n = 22) or 10% neutral buffered formalin(NBF)(n = 10).Immunohistochemistry(IHC) of HER-2 and PD-1 was performed, and a pathology examination was conducted. In the HER-2-immunoreactive cases, all four specimens were subjected to dual-color in situ hybridization(DISH). Five cases were assessed as HER-2-positive by IHC and DISH. We used the cut-off values of 1%, 10%, and 50% to assess the IHC findings of PD-L1.RESULTS No significant difference was observed in comparisons between the shorter fixation period groups(6 h, 24 h, and 48 h) and the prolonged fixation period(1 wk) group in the HER-2 and PD-L1 analyses. Although no significant difference was observed between 10% formalin and 10% NBF within 1 wk of fixation, the superiority of 10% NBF was confirmed in a long-term(> 3 mo) fixation in both the HER-2 and PD-L1 analyses.CONCLUSION In this small-numbered pilot study, prolonged fixation within 1 wk showed no inferiority in HER-2 or PD-L1 testing. However, a large-numbered prospective study is needed to obtain conclusive results. | Keita Kai Yukie Yoda Atsushi Kawaguchi Akimichi Minesaki Hironori Iwasaki Shinichi Aishima Hirokazu Noshiro | 2019 | World Journal of Clinical Cases2019，7，4： | 4 |
| 2 | Kobata, Newlydeveloped standard conductance element for in situ cali-bration of high vacuum gauges 显示文摘 | Yoshida H Kenta Arai Hitoshi Akimichi T | 2012 | Measurement2012，45，10： | 1 |
| 3 | Percutaneous Ethanol Injection via an Artificially Induced Right Hydrothorax for Hepatocellular Carcinoma in the Hepatic Dome显示文摘 | Akimichi Kume Yuji Nimura Junichi Kamiya Masato Nagino Yasushi Kito | 2003 | CardioVascular and Interventional Radiology2003，，6： | 1 |
| 4 | Solubility and viscosity of refrigerant/lubricant mixtures: hydrofluorocarbon/alkylbenzene systems显示文摘 | Katsuya Takigawa Stanley I. Sandler Akimichi Yokozeki | 2002 | International Journal of Refrigeration2002，，8： | 1 |
| 5 | Improvement in symptoms after H_2-receptor antagonist-based therapy for eradication of H pylori infection显示文摘AIM: To investigate the therapeutic effects of triple therapy combining lafutidine with clarithromycin and amoxicillin on H pylori infection and the resolution of gastroesophageal symptoms after eradication. METHODS: We conducted a randomized, multicenter, open-label controlled trial to compare the effective-ness of a triple therapy of lafutidine, clarithromycin, and amoxicillin (lafutidine group) with that of a triple therapy of lansoprazole, clarithromycin, and amoxicillin (lansopra- zole group) in patients with H pylori infection. The study group comprised 22 patients with gastric ulcers and 18 patients with duodenal ulcers who had H pylori infection. RESULTS: H pylori eradication rates were similar in the lafutidine group (14/20, 70%) and the lansoprazole group (14/20, 70%). Gastroesophageal reflux and ab-dominal symptoms improved after eradication therapy in both groups, whereas abdominal discomfort, diarrhea, and constipation were unchanged. H pylori status had no apparent effect on improvement of gastroesophageal reflux or abdominal symptoms after treatment. Adverse events were similar in both groups. CONCLUSION: The triple therapy including lafutidine is equivalent to triple therapy including lansoprazole in terms of H pylori eradication rates and improvement in gastroesophageal reflux and abdominal symptoms.These results are attributed to the fact that lafutidine has strong, continuous antisecretory activity, unaffected by CYP2C19 polymorphisms. | Takeshi Hagiwara Mototsugu Kato Tomonori Anbo Akimichi Imamura Toshihiro Suga Takumi Uchida Akira Fujinaga Manabu Nakagawa Soichi Nakagawa Yuichi Shimizu Jyunji Yamamoto Hiroshi Takeda Masahiro Asaka | 2007 | World Journal of Gastroenterology2007，13，28： | 1 |
| 6 | 显示文摘 | Akimichi H Arai T Takeuchi K | 1997 | J Vac Sci Technol A1997，15，3： | 1 |
| 7 | Fabrication and properties of high-strength extruded brass using elemental mixture of Cu–40% Zn alloy powder and Mg particle显示文摘 | Haruhiko Atsumi Hisashi Imai Shufeng Li Katsuyoshi Kondoh Yoshiharu Kousaka Akimichi Kojima | 2012 | Materials Chemistry and Physics (-)2012，，2： | 1 |
| 8 | The tube method for the moment index in projection pursuit显示文摘 | Satoshi Kuriki Akimichi Takemura | 2008 | Journal of Statistical Planning and Inference2008，138，6： | 1 |
| 9 | The tube method for the moment index in projection pursuit 显示文摘 | Satoshi Kuriki Akimichi Takemura | 2008 | Journal of Statistical Planning and Inference2008，138，6： | 1 |
| 10 | Novel Functions of Herbal Medicines in Dendritic Cells: Role of Amomi Semen in Tumor Immunity显示文摘 | Hajime Fukui Seika Mitsui Nobue Harima Mitsuhiko Nose Kunio Tsujimura Hajime Mizukami Akimichi Morita | 2007 | Microbiology and Immunology2007，，11： | 1 |
| 11 | The ecological aspect of Lau (Solomon Islands)ethnoichtyology显示文摘 | Tomoya 1978 | 1978 | Journal of the Polynesian Society1978，87，4： | 1 |
| 12 | High-strength, lead-free machinable α–β duplex phase brass Cu–40Zn–Cr–Fe–Sn–Bi alloys显示文摘 | Haruhiko Atsumi Hisashi Imai Shufeng Li Katsuyoshi Kondoh Yoshiharu Kousaka Akimichi Kojima | 2011 | Materials Science & Engineering A2011，，： | 1 |
| 13 | Newly Developed Standard Conductance Element for in Situ Cali- bration of High Vacuum Gauges显示文摘 | Hajime Yoshida Kenta Arai Hitoshi Akimichi | 2012 | Measurement2012，45，： | 1 |
| 14 | Percutaneous Ethanol Injection via an Artificially Induced Right Hydrothorax for Hepatocellular Carcinoma in the Hepatic Dome显示文摘 | Akimichi Kume Yuji Nimura Junichi Kamiya Masato Nagino Yasushi Kito | 2003 | CardioVascular and Interventional Radiology2003，，6： | 1 |
| 15 | Photocurrent generation in heterostructured ultrathin films fabricated by layerby-Layer deposition of polyelectrolytes bearing Tris(2,2'-bipyridine)ruthenium(Ⅱ) and ferrocene moieties显示文摘 | Toshiki Fushimi Akimichi Oda Hideo Ohkita Shinzaburo Ito | 2005 | Langmuir2005，21，4： | 1 |
| 16 | Improvement of the performance of the ionization gauge with energy filter for the measurement of an extremely high vacuum显示文摘 | AKIMICHI H TAKAHASHI N TANAKA T | 1996 | Vacuum1996，47，： | 1 |
| 17 | Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome显示文摘 | Rie Oka Junji Kobayashi Kunimasa Yagi Hideji Tanii Susumu Miyamoto Akimichi Asano Tomomi Hagishita Mika Mori Tadashi Moriuchi Makoto Kobayashi Shouji Katsuda Masa-aki Kawashiri Atsushi Nohara Yoshiyu Takeda Hiroshi Mabuchi Masakazu Yamagishi | 2007 | Diabetes Research and Clinical Practice2007，，： | 1 |
| 18 | Characteristics and machinability of lead-free P/M Cu60-Zn40 brass alloys dispersed with graphite显示文摘 | HISASHI I YOSHIHARU K AKIMICHI K | 2010 | Powder Technology2010，189，3： | 1 |
| 19 | Calibration of Ultrahigh Vacuum Gauge from 10-9 Pa to 10-5 Pa by the Two-Stage Flow-Dividing System显示文摘 | Yoshida H Hirata M Akimichi H | 2011 | Vacuum2011，86，： | 1 |
| 20 | Therapeutic Depletion of Myeloid Lineage Leukocytes in Patients with Generalized Pustular Psoriasis Indicates a Major Role for Neutrophils in the Immunopathogenesis of Psoriasis显示文摘 | Shigaku Ikeda Hidetoshi Takahashi Yasushi Suga Hikaru Eto Takafumi Etoh Keiko Okuma Kazuo Takahashi Takeshi Kanbara Mariko Seishima Akimichi Morita Yasutomo Imai Takuro Kanekura | 2012 | Journal of the American Academy of Dermatology2012，，： | 1 |
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