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| 1 | 重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余 | 焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 中华微生物学和免疫学杂志2002，22，1： | 3 |
| 2 | 重组卡介苗感染树突细胞的研究显示文摘在体内外试验中 ,树突细胞 (DC)均能摄取表达大肠杆菌麦芽糖结合蛋白 (MalE)的重组卡介苗 (rBCG·MalE)。应用流式细胞术测得荧光标记的rBCG·MalE在体内感染DC的水平在 1 % 2 % ,与感染巨噬细胞 (MΦ)的水平相当。体外抗原提呈试验结果显示 ,DC和MΦ能吞噬、加工rBCG·MalE并向T细胞杂交瘤FBU·B1 1提呈MalE蛋白抗原表位 ,而在体内试验中 ,从rBCG·MalE免疫小鼠脾脏中纯化的DC ,可检测到MalE表位MHCⅡ复合物 ,而纯化的MΦs却测不到。这表明DC在起始抗分枝杆菌的免疫保护中发挥关键作用。 | 焦新安 Richard Lo-Man Pierre Guermonprez Edith Dériaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 扬州大学学报(农业与生命科学版)2002，23，1： | 2 |
| 3 | Rapid determination of effective alkali and dead-load concentrations in kraft liquors by attenuated total reflectance infrared spectroscopy显示文摘 | Leclerc D F Hogikyan R M | 1995 | J Pulp Paper Sci1995，21，： | 1 |
| 4 | Hepatic release of interleukin-10 during cardiopulmonary bypass in steroidpretreated patients显示文摘 | WAN S LECLERC J I SCHMART Z D | 1997 | Am Heart J1997，133，4： | 1 |
| 5 | Polycarbazoles: 25 years of progress 显示文摘 | Morin J F Leclerc M Adbs D | 2005 | Macromolecular Rapid Communications2005，26，10： | 1 |
| 6 | EEG spectral analysis in wakefulness, REM andNREM sleep following sport-related concussions 显示文摘 | Gosselin N’Lassonde M Petit D Leclerc S Mongrain V Mont-plaisir J | 2007 | Sleep2007，，： | 1 |
| 7 | Relative salinity tolerance of potato cultivars assessed by in vitro screening显示文摘 | Khrais T Leclerc Y Danielle J D | 1998 | Am J Potato Res1998，75，5： | 1 |
| 8 | Brain functional reorganization in early blind human revealed by auditory event- related potentials显示文摘 | Leclerc C Saint-amour D Lvole ME | 2000 | Neuro Report2000，11，： | 1 |
| 9 | New well-defined poly ( 2, 7-fluorene ) derivatives : photoluminescene and base doping显示文摘 | RANGER M RONDEAU D LECLERC M | 1997 | Macromolecules1997，30，25： | 1 |
| 10 | Minimally conjoined omphalopagi: a consistent spectrum of anomalies显示文摘 | Poenaru D Uroz-Tristan J Leclerc S | 1994 | J Pediatr Surg1994，29，9： | 1 |
| 11 | Cloning and mapping of a c DNA for methionine synthase reductase,a flavoprotein defective in patients with homocystinuria显示文摘 | Leclerc D Wilson A Dumas R | 1998 | Proc Natl Acad Sci U S A1998，95，6： | 1 |
| 12 | Molecular basis for methionine synthase reductase deficiency in patients belonging to the cbl E complementation group of disorders in folate/cobalamin metabolism显示文摘 | Wilson A Leclerc D Rosenblatt DS | 1999 | Hum Mol Genet1999，8，11： | 1 |
| 13 | Cloning and mapping of a CDNA-NA for methionine synthase reductase,a flavoprotein defective in pa-tients with homocystinuria显示文摘 | Wilson A Dumas R | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 14 | New well-defined poly (2, 7-fluorene) derivatives: Photoluminescence and base doping显示文摘 | Ranger M Rondeau D Leclerc M | 1997 | Macromolecules1997，30，25： | 1 |
| 15 | Age and origin of Albi- an glauconites and associated clay minerals inferred from a de- tailed geochemical analysis 显示文摘 | Rousset D Leclerc S Clauer N | 2004 | Journal of Sedimentary Re- search2004，74，5： | 1 |
| 16 | Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria C显示文摘 | Dobson M Wai T Leclerc D | 2002 | Hum Mol Genet2002，11，26： | 1 |
| 17 | Gas-liquid selective oxidations with oxygen under explosive conditions in a micro- structured reactor显示文摘 | Leclerc A Alame M Schweich D | 2008 | Lab Chip2008，8，5： | 1 |
| 18 | Product and service delivery satisfaction among North American cruise passengers显示文摘 | Teye V B Leclerc D | | 0，，02： | 1 |
| 19 | Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders 显示文摘 | Leclerc D Campeau E Goyette P | 1996 | Hum Mol Genet1996，5，12： | 1 |
| 20 | UDP-glucuronosyhransferase in the rat olfactory Bulb: Identification of the UGT1A6 isoform and aged-related changes in 1-naphthnol glucuronidation显示文摘 | Gradinaru D Suleman F G Leclerc S | 1999 | Neurochemicol Research1999，24，8： | 1 |
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