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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Controver- sies in the Current Manageas显示文摘 | Moreno Egea A Baena Enrique G Calle Miquel C | 2007 | Arch Surg2007，142，： | 1 |
| 3 | Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths a longitudinal study显示文摘 | Giannini C Weiss R Call A | 2012 | Diabetes2012，61，3： | 1 |
| 4 | Cattle dung pat microenvironmental effects on germination and establishment on crested wheatgrass显示文摘 | Akbar G Call C A Wiedmeier R D | 1995 | Soil Research1995，，： | 1 |
| 5 | Human micorRNA genes are frequently located at fragile sites and genomic regions involved in cancers显示文摘 | CALLING A SEVIQNANI C DUMITRUC D | | 0，，： | 1 |
| 6 | Comparison of organic acid salts for Clostridium botulinum control in an uncured turkey product显示文摘 | Miller A J Call J E Whiting R C | 1993 | Journal of food protection1993，56，： | 1 |
| 7 | SrCo1-xSbxO3+δ perovskite oxides as cathode materials in solid oxide fuel cells 显示文摘 | AGUADERO A PEREZ-COLL D CALLE C | 2009 | J Power Sources2009，192，： | 1 |
| 8 | Creactive protein during nor-mal pregnancy and preeclampsia显示文摘 | Teran E Escudero C Calle A | 2005 | Int J Gynecol Obstet2005，89，： | 1 |
| 9 | SrCo1-xSbxO3-δ perovskite oxides as cathode materials in solid oxide fuel cells 显示文摘 | AGUADERO A PEREZ-COLL D DE LA CALLE C | 2009 | J Power Sources2009，192，： | 1 |
| 10 | C-reactive protein during normal pregnancy and preeclampsia显示文摘 | Teran E Escudero C Calle A | 2005 | Int J Gynecol Obstet2005，89，： | 1 |
| 11 | E~valuation of the R2R11M11O7 pyrochlores as cathodes in solid-oxide fuel cells 显示文摘 | CORONADO R M AGUADERO A CALLE C | 2011 | J Power Sources2011，196，： | 1 |
| 12 | Controversies in the Cur- rent Management of Lumbar Hernias I 显示文摘 | Moreno Egea A Baena Enrique G Calle Miquel C | 2007 | ArchSurg2007，142，1： | 1 |
| 13 | 显示文摘 | Calle M Garcia C Lozano A E | 2013 | Journal of Membrane Science2013，434，： | 1 |
| 14 | Natural revegetation ofan unreclaimed lignite surface mine in East - central Texas-USA)显示文摘 | Skousen J G Call C A Knight R W | 1990 | South-western Naturalist1990，35，9： | 1 |
| 15 | The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 显示文摘 | Camaschella C Roetto A Call A | 2000 | Nat Genet2000，25，1： | 1 |
| 16 | Estrogen replacement therapy and ovarian cancer mortality in a large prospect study of US Women显示文摘 | Rodriguez C Patel A V Calle E E | 2001 | Jama2001，285，11： | 1 |
| 17 | C-reactive protein during normal pregnancy and preeclampsia显示文摘 | Teran E Escudero C Calle A | 2005 | Int J Gynecol Obstet2005，89，2： | 1 |
| 18 | Nurses' Perception of Noise Levels in Hospitals in Spain显示文摘 | Marqu6s S6nchez del P Calle Pardo A P S6nchez D C | 2008 | J Nurs Adm2008，38，5： | 1 |
| 19 | Ce-ZSM-5 catalysts for the selective catalytic reduction of NOx in stationary diesel exhaust gas显示文摘 | Van KOOTEN W E J LIANG B KRIJNSEN H C OUDSHOORN O L CALLS H P A Van den BLEEK C M | 1999 | Appl Catal B1999，21，3： | 1 |
| 20 | Lung cancer,cardiopulmonary mortality and long_term exposure to fine particulate air pollution显示文摘 | Pope C A Burnett R T Thun M J Calle E E Krewski D Ito K Thurston G D | | 0，，： | 1 |
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