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您的检索式：作者名="Paride Abliz"
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| 1 | 疣状瓶霉致皮肤着色真菌病一例及致病菌的辅酶Q和DNA序列测定显示文摘目的报告1例疣状瓶霉致皮肤着色真菌病,并探讨其致病菌的实验室特征。方法皮损组织病理学检查、真菌学检查,分离株辅酶Q检测、DNA序列鉴定。结果该病表现为慢性疣状增殖性斑块,病程长,外伤后易发病。真皮层可见棕色厚壁孢子。菌落生长缓慢,需观察4周。小培养沙氏琼脂培养基无特殊结构,马铃薯葡萄糖琼脂见瓶梗多生长于短侧枝或气生菌丝顶端,玉米粉琼脂Ⅰ见瓶梗多侧生于菌丝,后两者其他结构相同。辅酶Q系统检测及LSUrDNA D1/D2区域碱基序列测定,与标准菌株比较完全相同。结论我国该病较少见,确诊需作真菌培养及组织病理,应同时采用沙氏琼脂培养基、马铃薯葡萄糖琼脂、玉米粉琼脂Ⅰ3种培养基培养。辅酶Q检测及分子生物学鉴定可排除表型不同的干扰,有利于进一步鉴定菌种。 | 周冼苡 Paride Abliz 龙泽香代子 席丽艳 | 2005 | 中华皮肤科杂志2005，38，2： | 3 |
| 2 | Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome显示文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection. | Hua Li Shuxian Wu Liming Mao Guowei Lei Liping Zhang Ailing Lu Liguo An Guiwen Yang Paride Abliz Guangxun Meng | 2013 | Protein & Cell2013，4，7： | 3 |
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