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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration显示文摘The renewal of lung epithelial cells is normally slow unless the lung is injured.The resident epithelial stem cells rapidly proliferate and differentiate to maintain lung structure and function when the lung is damaged.The alveolar epithelium is characterized by alveolar type 1(AT1)and alveolar type 2(AT2)cells.AT2 cells are the stem cells for alveoli,as they can both self-renew and generate AT1 cells.Abnormal proliferation and regulation of AT2 cells will lead to serious lung diseases including cancers.In this review,we focused on the alveolar stem/progenitor cells,the key physiological function of AT2 cells in lung homeostasis and the complicated regulation of AT2 cells in the repairing processes after lung injury. | Ailing Wu Hai Song | 2020 | Acta Biochimica et Biophysica Sinica2020，52，7： | 6 |
| 3 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 4 | Two-Phase Rate Adaptation Strategy for Improving Real-Time Video QoE in Mobile Networks显示文摘With the popularity of smart handheld devices, mobile streaming video has multiplied the global network traffic in recent years. A huge concern of users' quality of experience(Qo E) has made rate adaptation methods very attractive. In this paper, we propose a two-phase rate adaptation strategy to improve users' real-time video Qo E. First, to measure and assess video Qo E, we provide a continuous Qo E prediction engine modeled by RNN recurrent neural network. Different from traditional Qo E models which consider the Qo E-aware factors separately or incompletely, our RNN-Qo E model accounts for three descriptive factors(video quality, rebuffering, and rate change) and reflects the impact of cognitive memory and recency. Besides, the video playing is separated into the initial startup phase and the steady playback phase, and we takes different optimization goals for each phase: the former aims at shortening the startup delay while the latter ameliorates the video quality and the rebufferings. Simulation results have shown that RNN-Qo E can follow the subjective Qo E quite well, and the proposed strategy can effectively reduce the occurrence of rebufferings caused by the mismatch between the requested video rates and the fluctuated throughput and attains standout performance on real-time Qo E compared with classical rate adaption methods. | Ailing Xiao Jie Liu Yizhe Li Qiwei Song Ning Ge | 2018 | China Communications2018，15，10： | 3 |
| 5 | Hydroxyl radical formation upon dark oxidation of reduced iron minerals: Effects of iron species and environmental factors显示文摘Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic pollutants.Herein,we compared the hydroxyl radical formation from various reduced iron minerals at different redox conditions.·OH production was generally observed from the oxidation of reduced iron minerals,following the order:mackinawite(FeS)>reduced nontronite(iron-bearing smectite clay)> pyrite(FeS2)> side rite(FeCO3).Structural Fe^2+ and dissolved O2 play critical roles in ·OH production from reduced iron minerals.·OH production increases with decreasing pH,and Cl^-has little effect on this process.More importantly,dissolved organic matter significantly enhances ·OH production,especially under O2 purging,highlighting the importance of this process in ambient environments.This sunlight-independent pathway in which ’OH forms during oxidation of reduced iron minerals is helpful for understanding the degradation and transformation of various inorganic and organic pollutants in the redox-fluctuation environments. | Ailing Zhu Yingying Guo Guangliang Liu Maoyong Song Yong Liang Yong Cai Yongguang Yin | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 6 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 7 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 8 | Iron(Ⅱ) hydrides bearing a tetradentate PSNP ligand显示文摘A new class of iron(II) hydrides based on a tetradentate PSNP ligand were synthesized and fully characterized. All the iron(II) complexes feature a folded PSNP ligand with cis reactive sites. The hydrido iron complex [2 H(NCMe[2_TD$IF]1)](BF4) is capable of catalyzing aldehyde hydroboration by pinacolborane(HBpin) and with extremely high efficiency at room temperature. Aldehydes with various functional groups are compatible. | Jianguo Liu Ailing Zhang Heng Song Qingxiao Tong Chen-Ho Tung Wenguang Wang | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 9 | Enhanced confinement synthesis of atomically dispersed Fe-N-C catalyst from resin polymer for oxygen reduction显示文摘Due to larger atom utilization,unique electronic properties and unsaturated coordination,atomically dispersed non-precious metal catalysts with outstanding performances have received great attention in electrocatalysis.Considering the challenge of serious aggregation,rational synthesis of an atomic catalyst with good dispersion of atoms is paramount to the development of these catalysts.Herein,we report an enhanced confinement strategy to synthesize a catalyst comprised of atomically dispersed Fe supported on porous nitrogen-doped graphitic carbon from the novel and more cross-linkable Melamine-Glyoxal Resin.Densified isolated grid trapping,excessive melamine restricting,and nitrogen anchoring are strongly combined to ensure the final atomic-level dispersion of metal atoms.Experimental studies revealed enhanced kinetics of the obtained catalyst towards oxygen reduction reaction(ORR).This catalytic activity originates from the highly active surface with atomically dispersed iron sites as well as the multi-level three-dimensional structure with fast mass and electron transfer.The enhanced confinement strategy endows the resin-derived atomic catalyst with a great prospect to develop for commercialization in future. | Ailing Song Hao Tian Wang Yang Wu Yang Yuhan Xie Hao Liu Guoxiu Wang Guangjie Shao | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 10 | Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder显示文摘背景发现在 cyclin 依赖的象 kinase 一样的变化 5 (CDKL5 ) 基因与婴儿的癫痫的 encephalopathy 被联系刺激了世界范围的研究努力理解 CDKL5 的分子、基因的基础混乱。给远这样出版的文学的大数字,这评论试图总结当前的基因研究,在建议分子的功能上拉一致,并且指向在 CDKL5 研究的知识的差距。一个系统的评论过程用 PubMed 搜索引擎被进行集中于 CDKL5 研究在的方法最近十年。我们分析了这些出版物并且总结了调查结果进四节:基因研究, CDKL5 表达式模式,分子的函数,和动物模型。我们也在每节讨论了挑战和未来方向。临床的方面上的结果, CDKL5 混乱被早发作描绘癫痫的发作,智力的残疾,和 stereotypical 行为。在研究方面,在人的病人的一系列分子、基因的研究,房间文化和动物上,模型建立了 CDKL5 的诱发性到婴儿的癫痫的 encephalopathy,并且在在大脑调整 neuronal 功能为 CDKL5 指向了一个关键角色。CDKL5 混乱的老鼠模型也被开发了,并且尤其是,表明行为的显型, CDKL5 混乱的众多的临床的症状和进展 CDKL5 研究到现出症状之前的潜的阶段的 mimicking。我们远这样学习了的给的结论,柔韧、量、敏感的结果措施的未来鉴定将是在动物模型研究的钥匙,特别地在异质接合的女性。同时, CDKL5 的分子、细胞的研究应该集中于基于机制的调查和目的揭开提供潜力救或改善的 druggable 目标 CDKL5 混乱相关的显型。 | Ailing Zhou Song Han Zhaolan Joe Zhou | 2017 | Frontiers in Biology2017，12，1： | 0 |
| 11 | Health Status and Food Intake Frequency of Elderly Residents During COVID-19 Community Closure—Jiangxia District,Wuhan City,China,2020显示文摘What is already known about this topic?Elderly persons are vulnerable to infectious diseases,and nutritional status and health conditions were important to evaluate for disease prevention and ability to recover for the elderly during the coronavirus disease 2019(COVID-19)pandemic.What is added by this report?In our study,a rapid assessment questionnaire was used to investigate the change of household life and dietary intake of the elderly(aged 60 years or more)during community closure.Food consumption frequency of aquatic food products,soybeans,and fresh fruits declined dramatically with reductions of 70.9%,70.9%,and 53.0%,respectively,and 49.6%of the elderly lived with chronic non-communicable diseases but had little knowledge of nutrition and health.What are the implications for public health practice?Community closure measures in Wuhan City have played a key role in cutting off the transmission route of COVID-19 and protecting vulnerable groups.As a high-risk population,the elderly should be advised to maintain and strengthen a balanced diet with proper nutrition through increasing intake of aquatic food products,soybeans,fruits,and vegetables,reducing total caloric intake,and decreasing oil and salt consumption.These measures will be significant for the elderly to reduce the risk of chronic disease complications and COVID-19 infection and to decrease the chance of critical illness. | Pengkun Song Cheng Li Ganyu Feng Jian Zhang Li Li Titi Yang Mingna Dong Ailing Liu Qi Zhang Yujing Liu Jinglei Wang Tanxi Ge Qing Yu Gangqiang Ding | 2020 | China CDC weekly2020，2，27： | 0 |
| 12 | Diet and Nutrition of Healthcare Workers in COVID-19 Epidemic—Hubei,China,2019显示文摘From late January to March,more than 42,000 doctors,nurses,public health workers,and health administrators across China went to Hubei Province to assist in the response to coronavirus disease 2019(COVID-19).There are many studies on nutrition status of affected people amid natural disasters or pandemics(1–3),but the diet and nutrition status of healthcare workers receive little attention.The aim of this article is to provide evidence for addressing this issue by investigating food supply and nutrition status during the COVID-19 response period. | Jian Zhang Shanrong Lai Quanjun Lyu Pianhong Zhang Dagang Yang Juan Kong Yumei Qi Wei Yuan Shan Zeng Pengkun Song Titi Yang Li Li Jinglei Wang Yujing Liu Tanxi Ge Qi Zhang Ganyu Feng Ailing Liu Gangqiang Ding | 2020 | China CDC weekly2020，2，27： | 0 |
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