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| 1 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 2 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 3 | Measurement of in-vehicle volatile organic compounds under static conditions显示文摘在车辆内的不稳定的有机化合物(VOC ) 的类型和数量用 theThermodesorber 气体在静态的条件下面在一新车辆和二旧车辆被决定了用色层法分离 / 集中分光计(TD-GC/MS ) 。空气采样和分析在 USEPA 方法 TO-17.A 房间尺寸的要求下面被进行,环境测试房间被利用提供要求的环境条件(温度,湿度,水平、垂直的气流速度,和背景 VOCsconcentration ) 的稳定、精确的控制。尽管在每车辆以内检测的全部的不稳定的有机化合物( TVOC )的数量是相对不同的,静态的车辆测试表明了那(在新车辆 A ,在使用的车辆 B 的 1240 亩 g/m^3 ,和在使用的车辆 C 的 132 ng/m^3 的 4940 u.g/m^3 ),甲苯,二甲苯,一些芳香族化合物,和各种各样的C_7-C_( 12 )链烷在在测试的所有三车辆的占优势的 VOC 种类之中。另外, tetramethyl succinonitrile,可能源于泡沫垫子在车辆 B.The 类型被检测, VOC 的数量根据因素的各种各样的类型更加变化了,例如,车辆年龄,车辆模型,温度,空气汇率,和环境气流速度。例如,如果气流速度从 0.1 m/s 增加到 0.7 m/s, vehicle'sair 汇率从 0.15 h~ 增加(-1)to 0.67 h^( 从 1780 ~ 1201 ng/m^3 的 -1),and 在里面车辆 TVOC 集中减少。 | YOU Ke-wei GE Yun-shan HU Bin NING Zhan-wu ZHAO Shou-tang ZHANG Yan-ni XIE Peng | 2007 | Journal of Environmental Sciences2007，19，10： | 27 |
| 4 | Fairness-Oriented Hybrid Precoding for Massive MIMO Maritime Downlink Systems with Large-Scale CSIT显示文摘Different from conventional cellular networks, a maritime communication base station(BS) has to cover a much wider area due to the limitation of available BS sites. Accordingly the performance of users far away from the BS is poor in general. This renders the fairness among users a challenging issue for maritime communications. In this paper, we consider a practical massive MIMO maritime BS with hybrid digital and analog precoding. Only the large-scale channel state information at the transmitter(CSIT) is considered so as to reduce the implementation complexity and overhead of the system. On this basis, we address the problem of fairness-oriented precoding design. A max-min optimization problem is formulated and solved in an iterative way. Simulation results demonstrate that the proposed scheme performs much better than conventional hybrid precoding algorithms in terms of minimum achievable rate of all the users, for the typical three-ray maritime channel model. | Chengxiao Liu Wei Feng Te Wei Ning Ge | 2018 | China Communications2018，15，1： | 23 |
| 5 | Molecular network-based analysis of Guizhi- Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy显示文摘目的: Guizhi-Shaoyao-Zhimu 煎(GSZ ) ,繁体中文药(TCM ) 草药的公式,被显示出在糖尿病的外部神经病(DPN ) 的治疗有效。在这研究,网络分析被执行译解在 DPN 的处理的 GSZ 的分子的机制。 | Ning ZHAO Jian LI Li LI Xu-yan NIU Miao JIANG Xiao-juan HE Zhao-xiang BIAN Ge ZHANG Ai-ping LU | 2015 | Acta Pharmacologica Sinica2015，36，6： | 21 |
| 6 | Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor显示文摘AIM: To explore the expression and correlation of CD44v6,vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and matrix metalloproteinase (MMP)-9 in Krukenberg and primary epithelial ovarian carcinoma.METHODS: The expressions of CD44v6, VEGF, MMP-2and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma.RESULTS: The expression of CD44v6 (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue:x2= 4.516, P= 0.034; Krukenberg tumor tissue vsnormal ovarian tissue: x2 = 19.537, P= 0.001) and VEGF (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue: P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue: x2= 22.895, P = 0.001) was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue.The positive expression rate of MMP-2 and MMP-9 was 0%in the normal ovarian tissue. The positive expression rate of CD44v6 (x2 = 10.398, P = 0.001), VEGF (x2 = 13.149,P= 0.001), MMP-2 (x2= 33.668, P= 0.001) and MMP-9(x2= 38.839, P = 0.001) was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor.CONCLUSION: CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor. | Ge Lou Ying Gao Xiao-Ming Ning Qi-Fan Zhang | 2005 | World Journal of Gastroenterology2005，11，32： | 20 |
| 7 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 8 | Prevention of hepatocellular carcinoma in mice by IL-2 and B7-1 genes co-transfected liver cancer cell vaccines显示文摘AIM: To study the immunoprotective effect of liver cancer vaccine with co-transfected IL-2 and B7-1 genes on hepatocarcinogenesis in mice.METHODS: The murine liver cancer cell line Hepal-6 was transfected with IL-2 and/or B7-1 gene via recombinant adenoviral vectors and the liver cancer vaccines were prepared. C57BL/6 mice were immunized with these vaccines and challenged with the parental Hepal-6 cells afterwards.The immunoprotection was investigated and the reactive T cell line was assayed.RESULTS: The immunoprotection of the tumor vaccine was demonstrated. The effect of IL-2 and B7-1 genes cotransfected Hepal-6 liver cancer vaccine (Hep6-IL2/B7vaccine) on the onset of tumor formation was the strongest.When attacked with wild Hepal-6 cells, the median survival period of the mice immunized with Hep6-IL2/B7 vaccine was the longest (68 days, χ2=7.70-11.69, P<0.05) and the implanted tumor was the smallest (z =3.20-44.10, P<0.05).The effect of single IL-2 or B7-1 gene-transfected vaccine was next to the IL2/B7 gene co-transfected group, and the mean survival periods were 59 and 54 days, respectively.The mean survival periods of wild or enhanced green fluorescence protein gene modified vaccine immunized group were 51 and 48 days, respectively. The mice in control group all died within 38 days and the implanted tumor was the largest (z=3.20-40.21, P<0.05). The cellular immunofunction test and cytotoxicity study showed that the natural killer (NK) cell, lymphokine activated killer (LAK) cell and cytotoxic T lymphocyte (CTL) activities were significantly increased in mice immunized with the Hep6-IL2/B7 vaccine, (29.5±2.5%,65.0±2.9%, 83.1±1.5% respectively, compared with other groups, P<0.05).CONCLUSION: The Hep6-IL2/B7 liver cancer vaccines can induce the mice to produce activated and specific CTL against the parental tumor cells, and demonstrate stronger effect on the hepatocarcinogenesis than single gene modified or the regular tumor vaccine. Therefore, the vaccines may become a novel potential therapy for recurrence and metastasis of HCC. | Ning-Ling Ge Sheng-Long Ye Ning Zheng Rui-Xia Sun Yin-Kun Liu Zhao-You Tang, Liver Cancer Institute of Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China | 2003 | World Journal of Gastroenterology2003，9，10： | 19 |
| 9 | Atorvastatin reduces myocardial fibrosis in a rat model with post- myocardial infarction heart failure by increasing the matrix metaHoproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio显示文摘 | AN Zhe YANG Guang HE Yu-quan DONG Ning GE Li-li LI Shu-mei ZHANG Wen-qi | 2013 | Chinese Medical Journal2013，，11： | 17 |
| 10 | Focusing on the meso-scales of multi-scale phenomena-In search for a new paradigm in chemical engineering显示文摘To celebrate the 90th birthday of Professor Mooson Kwauk,who supervised the multi-scale research at this Institute in the last three decades,we dedicate this paper outlining our thoughts on this subject accumulated from our previous studies.In the process of developing,improving and extending the energyminimization multi-scale(EMMS)method,we have gradually recognized that meso-scales are critical to the understanding of the different kinds of multi-scale structures and systems.It is a common challenge not only for chemical engineering but also for almost all disciplines of science and engineering,due to its importance in bridging micro-and macro-behaviors and in displaying complexity and diversity.It is believed that there may exist a common law behind meso-scales of different problems,possibly even in different fields.Therefore,a breakthrough in the understanding of meso-scales will help materialize a revolutionary progress,with respect to modeling,computation and application. | Jinghai Li Wei Ge Wei Wang Ning Yang | 2010 | Particuology2010，8，6： | 16 |
| 11 | Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca^(2+)-CaMKII-CREB pathway显示文摘The present study was aimed at determining the effects of Tongqiao Huoxue Decoction(TQHXD) on the Ca2+-Ca MKII-CREB pathway and the memory and learning capacities of rats with vascular dementia(VD). The rat VD model was established by using an improved bilateral carotid artery ligation method. The Morris water maze experiment was used to evaluate the ethology of the VD rats following treatments with TQHXD at 3.01, 6.02, and 12.04 g·kg–1 per day for 31 days. At the end of experiment, the hippocampus were harvested and analyzed. Western blotting and RT-PCR were used to measure the expression levels of calmodulin-binding protein kinase II(Ca MKII), protein kinase A(PKA), c AMP-response element binding protein(CREB), and three N-methyl-D-aspartic acid receptor subunits(NR1, NR2 A, and NR2B). Our results revealed that TQHXD could alleviate the loss of learning abilities and increase the memory capacity(P < 0.05 and P < 0.01 vs the model group, respectively). The treatment with 6.02 and 12.04 g·kg–1 of TQHXD significantly up-regulated the Ca2+-Ca MKII-CREB pathway in the hippocampus. In conclusion, TQHXD showed therapeutic effects on a bilateral carotid artery ligation-induced vascular dementia model, through the up-regulation of calcium signalling pathways. | GE Chao-Liang WANG Xin-Ming HUANG Zhao-Gang XIA Quan WANG Ning XU Du-Juan | 2015 | Chinese Journal of Natural Medicines2015，13，11： | 15 |
| 12 | MiRNA-218, a new regulator of HMGB1, suppresses cell migration and invasion in non-small cell lung cancer显示文摘基因表示的否定管理者在癌症转移包含了的 MicroRNAs (miRNAs ) 功能。这研究的目的是在非小的房间肺癌症调查 miR-218 的潜在的角色并且验证它的规定机制。功能的研究证明 miR-218 overexpression 禁止了房间移植和侵略,但是没在房间生存能力上有效果。提高的绿色荧光灯蛋白质记者试金,即时聚合酶链反应和西方的污点分析证实 miR-218 由直接指向它的 3-untranslated 区域压制了高活动性组 box-1 (HMGB1 ) 的表示。因此,在房间移植和侵略上与 miR-218 的效果给予的 HMGB1 的 silencing,和 HMGB1 的 overexpression 能恢复被 miR-218 减少的房间移植和侵略。在结论,这些调查结果证明 miR-218 在肺癌症作为肿瘤 suppressor 工作。而且, miR-218 可以为变形的肺癌症病人充当潜在的治疗学的 biomarker。 | Cailian Zhang Shengli Ge Cailian Hu Ning Yang Jinran Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 14 |
| 13 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 14 | Physicians’Perception of Palliative Care Consultation Service in a Major General Hospital in China显示文摘Objectives The in-hosptial palliative care consultation(PCC)is emerging as a routine service in some medical center in China.The current study evaluated how physicians in primary care team and consultation team perceive the PCC service for the purpose of investigating the effectiveness of this consultation model in a general hospital.Methods In-hosptial palliative care consultations have been carried out at Peking Union Medical College Hosptial by a dedicated consultation team,and37consultations were completed in2016.A questionnaire was designed for physicians in terms of its benefits to patients,their family as well as the primary care team.Physicians who applied for consultation in2016formally(requested from the department other than the Geriatrics)and informally(by rotating residents and unemployed visiting doctors in geriatric department)were invited to participate in the survey by scanning a two dimentional code on social networking platform.Results There were103physicians participated in the survey,including primary care physicians from the department of Internal Medicine(n=8),Gynaecology(n=16)and Surgery(n=13),rotating residents(n=30),visiting doctors(n=16)in Geriatric department,and PCC team members(n=20).94.0%of the non-PCC physicians agreed that PCC relieved the suffering of patients;89.2%thought PCC improved the quality of patients'life;there were91.6%,95.2%,90.4%physicians who felt it relieved the anxiety of patients,of family members and of care providers,respectively.There were96.4%physicians who felt it could ease the tension in physician-patient relationship;97.6%felt it lower the risk for medical negligence,and96.4%of doctors who applied for PPC felt satisfied with PCC service in terms of process and achieving objectives of consultation.More primary-team physician agree'PCC service helps the physicians better understand palliative care'than PCC members(97.6%vs.80%,P<0.05),while both were interested in learning more on palliative medicine(100%vs.96.4%,P>0.05). | Xuan Qu Nan Jiang Nan Ge Xiaohong Ning | 2018 | Chinese Medical Sciences Journal2018，33，4： | 9 |
| 15 | HIV and syphilis infections among street-based female sex workers in China, 2010-2012显示文摘 | Li Dongmin Wang Lu Lin Wen Li Peilong Wang Lan Guo Wei Ge Lin Ding Zhengwei Cui Yan Wang Ning | 2014 | Chinese Medical Journal2014，，4： | 7 |
| 16 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 17 | Effects of Xiangsha Liujunzi decoction drug serum on gastric antrum smooth muscle cells from rats with functional dyspepsia by regulating gastrointestinal hormones显示文摘Objective:To observe the effect and mechanism of Xiangsha Liujunzi decoction(XSLJZD)drug serum on gastric antrum smooth muscle cells(SMCs)in rats with functional dyspepsia(FD).Methods:Gastric antrum SMCs from rats with FD were isolated,cultured,and then divided into six groups as follows:control,model,domperidone,low-dose XSLJZD(LXSLJZD),medium-dose XSLJZD(MXSLJZD),and high-dose XSLJZD(HXSLJZD).Each group was administered the corresponding drug serum for intervention.Drug serum intervention conditions and proliferative activity of SMCs were tested by cholecystokinin octapeptide.Ghrelin,gastrin,somatostatin,and substance P(SP)levels were measured by ELISA.Somatostatin and SP mRNA expression was measured by real-time PCR.Results:A concentration of 10%drug serum for 24 h was decided to be the best intervention condition for later study.The mean optical density value in the model group was lower than that in the control group(P紏.001).Optical density values in the domperidone and HXSLJZD groups were higher than those in the model group(P?.025,P?.032,respectively).Gastrin,SP,and ghrelin levels in the model group were lower(P?.007,P?.037,P?.005,respectively),but somatostatin levels were higher,compared with those in the control group(P?.031).Gastrin,SP,and ghrelin levels in the domperidone,MXSLJZD,and HXSLJZD groups were higher than those in the model group(all P<.05).Somatostatin levels in the four drug-treated groups were lower than those in the model group(P?.002,P?.007,P?.001,P?.009,respectively).SP mRNA levels in the model group were lower than those in the control,domperidone,MXSLJZD,and HXSLJZD groups(P?.037 P?.016,P?.025,P?.002,respectively).Somatostatin mRNA levels in the model group were higher than those in the control and MXSLJZD groups(P紏.042,P紏.035).Conclusions:XSLJZD and domperidone drug serum effectively promote proliferative activity of gastric antrum SMCs in an FD model.The mechanism of this activity may be regulated by gastrointestinal hormones. | Ning Dai Jinghong Hu Yan Liu Dongyu Ge Ruijuan Dong Fengzhi Wu Jiaojiao Yu Mindan Chen Deborah CMa Feng Li | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 6 |
| 18 | Effects of groundwater level on vegetation in the arid area of western China显示文摘At present,investigation about the relationship between the change of groundwater level and vegetation mostly focuses on specific watersheds,i.e.limited in river catchment scale.Understanding the change of groundwater level on vegetation in the basin or large scale,be urgently needed.To fill this gap,two typical arid areas in the west of China(Tarim Basin and Qaidam Basin)were chosen the a typical research area.The vegetation status was evaluated via normalization difference vegetation index(NDVI)from 2000 to 2016,sourced from MODN1F dataset.The data used to reflect climate change were download from CMDSC(http://gffzz4229473beeb04795hvxuv5pvkxbvw66cc.ffgz.tsg.suse.edu.cn).Groundwater level data was collected from monitor wells.Then,the relationship of vegetation and climate change was established with univariate linear regression and correlation analysis approach.Results show that:Generally,NDVI value in the study area decreased before 2004 then increased in the research period.Severe degradation was observed in the center of the basin.The area with an NDVI value>0.5 decreased from 12%to 6%between 2000 and 2004.From 2004 to 2014,the vegetation in the study area was gradually restored.The whole coverage of Qaidam Basin was low.And the NDVI around East Taigener salt-lake degraded significantly,from 0.596 to 0.005,2014 and 2016,respectively.The fluctuation of groundwater level is the main reason for the change of surface vegetation coverage during the vegetation degradation in the basin.However,the average annual precipitation in the study area is low,which is not enough to have a significant impact on vegetation growth.The annual average precipitation showed an increase trend during the vegetation restoration in the basin,which alleviates the water shortage of vegetation growth in the region.Meanwhile,the dependence of surface vegetation on groundwater is obviously weakened with the correlation index is−0.248.The research results are of some significance to eco-environment protection in the arid area of western China. | Ge Song Jin-ting Huang Bo-han Ning Jia-wei Wang Lei Zeng | 2021 | China Geology2021，4，3： | 6 |
| 19 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 20 | The Influence of Normal Load and Sliding Speed on Frictional Properties of Skin显示文摘The study of frictional properties of human skin is important for medical research, skin care products and textile exploi-tation. In order to investigate the influence of normal load and sliding speed on the frictional properties of skin and its possible mechanism, tests were carried out on a multi-specimen friction tester. When the normal load increases from 0.1 N to 0.9 N, normal displacement and the friction coefficient of skin increase. The friction coefficient is dependent on the load, indicating that both adhesion and deformation contribute to the friction behaviour. The deformation friction was interpreted using the plough model of friction. When sliding speed increases from 0.5 mm·s?1 to 4 mm·s?1, the friction coefficient increases and 'stick-slip' phenomena increase, indicating that hysteretic friction contributes to the friction. The hysteretic friction was in-terpreted using schematic of energy translation during the rigid spherical probe sliding on the soft skin surface, which provides an explanation for the influence of the sliding speed on the frictional characteristics of the skin. | Wei Tang Shi-rong Ge Hua Zhu Xi-chuan Cao Ning Li | 2008 | Journal of Bionic Engineering2008，5，1： | 5 |
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