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| 1 | Gastrointestinal complications of diabetes mellitus显示文摘Diabetes mellitus affects virtually every organ system in the body and the degree of organ involvement depends on the duration and severity of the disease,and other co-morbidities.Gastrointestinal(GI) involvement can present with esophageal dysmotility,gastro-esophageal reflux disease(GERD),gastroparesis,enteropathy,non alcoholic fatty liver disease(NAFLD) and glycogenic hepatopathy.Severity of GERD is inversely related to glycemic control and management is with prokinetics and proton pump inhibitors.Diabetic gastroparesis manifests as early satiety,bloating,vomiting,abdominal pain and erratic glycemic control.Gastric emptying scintigraphy is considered the gold standard test for diagnosis.Management includes dietary modifications,maintaining euglycemia,prokinetics,endoscopic and surgical treatments.Diabetic enteropathy is also common and management involves glycemic control and symptomatic measures.NAFLD is considered a hepatic manifestation of metabolic syndrome and treatment ismainly lifestyle measures,with diabetes and dyslipidemia management when coexistent.Glycogenic hepatopathy is a manifestation of poorly controlled type 1 diabetes and is managed by prompt insulin treatment.Though GI complications of diabetes are relatively common,awareness about its manifestations and treatment options are low among physicians.Optimal management of GI complications is important for appropriate metabolic control of diabetes and improvement in quality of life of the patient.This review is an update on the GI complications of diabetes,their pathophysiology,diagnostic evaluation and management. | Babu Krishnan Shithu Babu Jessica Walker Adrian B Walker Joseph M Pappachan | 2013 | World Journal of Diabetes2013，4，3： | 10 |
| 2 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 3 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 4 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 5 | Testosterone,cardiomyopathies,and heart failure:a narrative review显示文摘Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure. | Rodica Diaconu Ionuţ Donoiu Oana Mirea Tudor Adrian Bălşeanu | 2021 | Asian Journal of Andrology2021，23，4： | 2 |
| 6 | Nearest interval, triangular and trapezoidal approximation of a fuzzy number preserving ambiguity显示文摘 | Adrian I B Lucian C | 2012 | International Journal of Approximate Reasoning2012，53，： | 1 |
| 7 | System identification of nonlinear state - space models 显示文摘 | T B Schon Adrian Wills Brett Ninness | 2011 | Automatica2011，47，： | 1 |
| 8 | Three-dimensional vortex organization in a high-Reynolds-number supersonic turbulent boundary layer显示文摘 | Elsinga G E Adrian R J Van Oudheusden B W | 2010 | J Fluid Mech2010，644，： | 1 |
| 9 | Optimization of hydrophilie matrix tablets using a D-optimal design显示文摘 | ADRIAN B SORIN EL | 1997 | Int J Pharm1997，153，2： | 1 |
| 10 | The role of transforming growth factor-beta (TGF- beta) during ovarian follicular development in sheep 显示文摘 | JENNIFER L J ADRIAN H B KAREN L R | 2004 | Reproductive Biology and Endocrinology2004，2，： | 1 |
| 11 | Toughening tetrafunctional epoxy resins using polyetherimide显示文摘 | Clive B Bucknall Adrian H Gilbert | 1989 | Polymer1989，30，2： | 1 |
| 12 | Theoretical com- parison of low GWP alternatives for different refrigeration configurations taking R404A as baseline显示文摘 | Adrian M B Joaquin N E Angel B | 2014 | International Journal of Refrigeration2014，44，1： | 1 |
| 13 | Drop-in energy performance evaluation of R1234yf and R1234ze(E) in a vapor compression system as R134a replacements 显示文摘 | Adrian M B Joaquin N E Angel B | 2014 | Ap- plied Thermal Engineering2014，71，1： | 1 |
| 14 | 5-Lipoxygenase and Leukotriene B 4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue显示文摘 | René Hennig Xian-Zhong Ding Wei-Gang Tong Matthias B. Schneider Jens Standop Helmut Friess Markus W. Büchler Parviz M. Pour Thomas E. Adrian | 2002 | The American Journal of Pathology2002，，2： | 1 |
| 15 | Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland显示文摘 | MICHEAL B STEPHAN R M ADRIAN W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 16 | Highly Ef- ficient Cu( In, Ga)Se2 Solar Cells Grown on Flexible Pol- ymer Films 显示文摘 | ADRIAN C STEPHAN B FABIAN P | 2011 | NATURE MATERIALS2011，10，11： | 1 |
| 17 | Water use efficiency in the hotel sector of Barbados 显示文摘 | Nadim C Adrian C Robert B | 2011 | Journal of Sustainable Tourism2011，19，2： | 1 |
| 18 | Watermarking graphical objects显示文摘 | Thomas H Adrian D B | 2002 | Proceedings of International Conference Image Processing2002，3，： | 1 |
| 19 | Incorporation of thymidine - H3 by cells in normal and injured mouse spinal cord 显示文摘 | Adrian E K Walker B E | 1962 | J Neuropathol Exp Neurol1962，21，： | 1 |
| 20 | DNA mehtylation patterns and epigenetic memory显示文摘 | | 2002 | Genes Dev2002，16，1： | 1 |
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