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| 1 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 2 | PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals显示文摘 | Maria Antonella Burza Carlo Pirazzi Cristina Maglio Kajsa Sj?holm Rosellina Margherita Mancina Per-Arne Svensson Peter Jacobson Martin Adiels Marco Giorgio Baroni Jan Borén Stefano Ginanni Corradini Tiziana Montalcini Lars Sj?str?m Lena Mariana Susann Car | 2012 | Digestive and Liver Disease2012，，12： | 2 |
| 3 | Overproduc-tion of large VLDL particles is driven by increased liver fat content in man显示文摘 | Adiels M Taskinen MR Packard C | 2006 | Diabetologia2006，49，4： | 1 |
| 4 | Fatty liver, insulin resistance, and dyslipidemia显示文摘 | Adiels M Taskinen MR BorOn J | 2008 | Curt Diab Rep2008，8，1： | 1 |
| 5 | Inverse correlation between coronary and retinal blood flows in patients with normal coronary arteries and slow coronary blood flow显示文摘 | Yaron Arbel Amir Sternfeld Adiel Barak Zvia Burgansky-Eliash Amir Halkin Shlomo Berliner Itzhak Herz Gad Keren Ardon Rubinstein Shmuel Banai Ariel Finkelstein | 2014 | Atherosclerosis2014，，1： | 1 |
| 6 | Young women partition fatty acids towards ketone body production rather than VLDL -TAG synthesis, compared with young men显示文摘 | arinou K Adiels M Hodson L | 2011 | Br J Nutr2011，105，6： | 1 |
| 7 | Ceramide: A potential mediator of apoptosis in human retinal pigment epithelial cells显示文摘 | Adiel B Lawrence SM Tzipora G | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 8 | Cardiac Steatosis Associates With Visceral Obesity in Nondiabetic Obese Men显示文摘 | Marit Granér Reijo Siren Kristofer Nyman Jesper Lundbom Antti Hakkarainen Markku O. Pentik?inen Kirsi Lauerma Nina Lundbom Martin Adiels Markku S. Nieminen Marja-Riitta Taskinen | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，3： | 1 |
| 9 | Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects 显示文摘 | Taskinen MR Adiels M Westerbacka J | 2011 | Arterioscler Thromb Vase Biol2011，31，9： | 1 |
| 10 | Fatty liver,insulin resistance,and dyslipidemia显示文摘 | Taskinen MR Borén J | 2008 | Curr Diab Rep2008，8，1： | 1 |
| 11 | Fatty liver, insulin resistance, and dyslipidemia 显示文摘 | Adiels M Taskinen MR Born J | 2008 | CUlT Diab Rep2008，8，1： | 1 |
| 12 | Patatin-like phospholipase domain-containing 3 ( PNPLA3 ) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro显示文摘 | Carlo Pirazzi Martin Adiels Maria Antonella Burza Rosellina Margherita Mancina Malin Levin Marcus St?hlman Marja-Riitta Taskinen Marju Orho-Melander Jeanna Perman Arturo Pujia Linda Andersson Cristina Maglio Tiziana Montalcini Olov Wiklund Jan Borén Stefa | 2012 | Journal of Hepatology2012，，6： | 1 |
| 13 | Intravitreal Triamcinolone in jection for Diffuse Diabetic Macular Edema With Foveal Cystoid Changes显示文摘 | Adiel Barak MD Miclael Regenbogen MD Michaella Goldstein MD and Anat Loenenstein MD | 2006 | I-MAJ2006，8，2： | 1 |
| 14 | A multiple criteria decision model for assig- ning priorities to activities in project management 显示文摘 | Mota Caroline Maria de Miranda de Almeida Adiel Teixeira | 2009 | International Journal of Project Management2009，27，2： | 1 |
| 15 | Early and widespread injury of astrocytes in the absence of demyelination in acute haemorrhagic leukoencephalitis显示文摘 | Robinson CA Adiele RC Tham M | 2014 | Acta Neuropathol Commun2014，2，1： | 1 |
| 16 | Diabetic dyslip-idaemia显示文摘 | Adiels M Olofsson SO Taskinen MR | 2006 | Curr Opin Lipidol2006，17，2： | 1 |
| 17 | Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistenc显示文摘 | Eitan R Adiel L Irine Ronin | 2010 | Biol and Compl Biol2010，107，12： | 1 |
| 18 | Overproductionof very low-density lipoproteins is the hallmark of the dys-lipidemia in the metabolic syndrome显示文摘 | Adiels M Olofsson S Taskinen M | 2008 | ArteriosclerThromb Vasc Biol2008，28，7： | 1 |
| 19 | Ceramide:a potential mediator of apoptosis in human retinal pigment epithelial cells显示文摘 | Adiel B Lawrence SM Tzipora G | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 20 | Reinsurance and Management of Regulatory Ratios and Taxes in the Property-Casualty Insurance Industry显示文摘 | Adiel R | 1996 | Journal of Accounting and Economics1996，22，13： | 1 |
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