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| 1 | Stroke-induced immunosuppression and poststroke infection显示文摘Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients.Approaches for effective management of poststroke infection remain scarce,presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke.Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections,suggesting that the modification of impaired immune defence could be beneficial.In this review,we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression.Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system. | Kaibin Shi Kristofer Wood Fu-Dong Shi Xiaoying Wang Qiang Liu | 2018 | Stroke & Vascular Neurology2018，3，1： | 17 |
| 2 | Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH) leads to high rates of death and disability. The pronounced infl ammatory reactions that rapidly follow ICH contribute to disease progression. Our recent clinical trial demonstrated that oral administration of an immune modulator fingolimod restrained secondary injury derived from initial hematoma,but the mechanisms remain unknown. In this study,we aim to investigate the effects of fingolimod on inflammatory mediators and vascular permeability in the clinical trial of oral fingolimod for intracerebral hemorrhage(ICH). The results showed that fingolimod decreased the numbers of circulating CD4^+ T,CD8^+ T,CD(19)^+B,NK,and NKT cells and they recovered quickly after the drug was stopped. The plasma ICAM level was decreased and IL-10 was increased by fingolimod. Interestingly,fingolimod protected vascular permeability as indicated by a decreased plasma level of MMP9 and the reduced r T1%. In conclusion,modulation of systemic inflammation by fingolimod demonstrates that it is an effective therapeutic agent for ICH. Fingolimod may prevent perihematomal edema enlargement by protecting vascular permeability. | Yu-Jing Li Guo-Qiang Chang Yuanchu Liu Ye Gong Chunsheng Yang Kristofer Wood Fu-Dong Shi Ying Fu Yaping Yan | 2015 | Neuroscience Bulletin2015，31，6： | 12 |
| 3 | Cadmium nanoclusters in a protein matrix: Synthesis, characterization, and application in targeted drug delivery and cellular imaging显示文摘Biotemplated 金属 nanoclusters 在 biosensing, bioimaging,催化作用,和 nanomedicine 由于他们潜在的应用的宽范围积累了许多注意。这里,我们报导马厩的合成, biocompatible,水溶性、高度荧光灯的牛的浆液白朊模板镉 nanoclusters (Cd 通过一个灵巧的一个壶绿色方法的 NC ) 。我们 covalently 结合了玻尿的酸(哈) 到 Cd 形成的 NC 一 pH 应答,有为 doxorubicin (纪录影片) 的持续版本侧面的 tumortargeting theranostic nanocarrier,模型 anticancer 药。nanocarrier 显示出大约 75.6% 的纪录影片封装效率。纪录影片版本侧面表明 74% 纪录影片在 pH 被释放 5.3,当不到 26% 纪录影片在 pH 被释放时 7.4 在一样的 24-h 时期以内。nanocarrier 有选择地认出了表示 CD44 的 MCF-7 乳癌房间,房间表面受体为哈,而没有如此的识别被观察与哈受体否定的 HEK293 房间。nanocarrier 的 Biocompatibility 与 HEK293 和 MCF-7 房间通过 cytotoxicity 试金被评估。展出的 nanocarrier 对没有 cytotoxicity 很低,而装载纪录影片的 nanocarrier 显示出可观的细胞的举起并且提高了 MCF-7 乳癌杀死房间的能力。我们也证实了使用的可行性高度荧光灯为 MCF-7 和 HeLa 房间的 bioimaging 的 nanoconjugate。优异的指向的药交货功效,细胞的成像能力,和低 cytotoxicity 用有希望的生物医学的应用作为令人激动的新 nanoplatform 放这 nanoconjugate。 | Morteza Sarparast Abolhassan Noori Hoda Ilkhani S. Zahra Bathaie Maher F. EI-Kady Lisa J. Wang Huong Pham Kristofer L. Marsh Richard B. Kaner Mir F. Mousavi | 2016 | Nano Research2016，9，11： | 5 |
| 4 | Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system显示文摘Nowadays, genome editing tools are indispensable for studying gene function in order to increase our knowledge of biochemical processes and disease mechanisms. The extensive availability of mutagenesis and transgenesis tools make Drosophila melanogaster an excellent model organism for geneticists. Early mutagenesis tools relied on chemical or physical methods,ethyl methane sulfonate(EMS) and X-rays respectively, to randomly alter DNA at a nucleotide or chromosomal level. Since the discovery of transposable elements and the availability of the complete fly genome, specific genome editing tools, such as P-elements, zinc-finger nucleases(ZFNs) and transcription activator-like effector nucleases(TALENs), have undergone rapid development. Currently, one of the leading and most effective contemporary tools is the CRISPR-cas9 system made popular because of its low cost, effectiveness, specificity and simplicity of use. This review briefly addresses the most commonly used mutagenesis and transgenesis tools in Drosophila, followed by an in-depth review of the multipurpose CRISPR-Cas9 system and its current applications. | Xingjie Ren Kristof Holsteens Haiyi Li Jin Sun Yifan Zhang Lu-Ping Liu Qingfei Liu Jian-Quan Ni | 2017 | Science China(Life Sciences)2017，60，5： | 5 |
| 5 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 6 | Embedding hollow Co3O4 nanoboxes into a three- dimensional macroporous graphene framework for high-performance energy storage devices显示文摘 | Mengping Li Maher F. EI-Kady Jee Y. Hwang Matthew D. Kowal Kristofer Marsh Haosen Wang Zhijuan Zhao Richard B. Kaner | 2018 | Nano Research2018，11，5： | 3 |
| 7 | High-throughput prediction of the ground-state collinear magnetic order of inorganic materials using Density Functional Theory显示文摘We present a robust,automatic high-throughput workflow for the calculation of magnetic ground state of solid-state inorganic crystals,whether ferromagnetic,antiferromagnetic or ferrimagnetic,and their associated magnetic moments within the framework of collinear spin-polarized Density Functional Theory.This is done through a computationally efficient scheme whereby plausible magnetic orderings are first enumerated and prioritized based on symmetry,and then relaxed and their energies determined through conventional DFT+U calculations.This automated workflow is formalized using the atomate code for reliable,systematic use at a scale appropriate for thousands of materials and is fully customizable.The performance of the workflow is evaluated against a benchmark of 64 experimentally known mostly ionic magnetic materials of non-trivial magnetic order and by the calculation of over 500 distinct magnetic orderings.A non-ferromagnetic ground state is correctly predicted in 95% of the benchmark materials,with the experimentally determined ground state ordering found exactly in over 60% of cases.Knowledge of the ground state magnetic order at scale opens up the possibility of high-throughput screening studies based on magnetic properties,thereby accelerating discovery and understanding of new functional materials. | Matthew Kristofer Horton Joseph Harold Montoya Miao Liu Kristin Aslaug Persson | 2019 | npj Computational Materials2019，，1： | 3 |
| 8 | Phylogenetic and morphological significance of an overlooked flying squirrel(Pteromyini,Rodentia)from the eastern Himalayas with the description of a new genus显示文摘The flying squirrels(Pteromyini,Rodentia)are the most diverse and widely distributed group of gliding mammals.Taxonomic boundaries and relationships within flying squirrels remain an area of active research in mammalogy.The discovery of new specimens of Pteromys(Hylopetes)leonardi Thomas,1921,previously considered a synonym of Hylopetes alboniger,in Yunnan Province,China allowed a morphological and genetic reassessment of the status of this taxon.Phylogenetic reconstruction was implemented using sequences of two mitochondrial(12S ribosomal RNA and 16S ribosomal RNA)and one nuclear(interphotoreceptor retinoid-binding protein)gene fragments.Morphological assessments involved examinations of features preserved on skins,skulls,and penises of museum specimens,supplemented with principal component analysis of craniometric data.Together these assessments revealed that this taxon should be recognized not only as a distinct species,but should also be placed within a new genus,described here as Priapomys gen.nov. | Quan Li Feng Cheng Stephen M.Jackson Kristofer M.Helgen Wen-Yu Song Shao-Ying Liu Daosavanh Sanamxay Song Li Fei Li Yun Xiong Jun Sun Hong-Jiao Wang Xue-Long Jiang | 2021 | Zoological Research2021，42，4： | 3 |
| 9 | Synthesis, Crystal Structure and Catalytic Properties of a 2D Cobalt(II) Coordination Polymer Based on Mixed Ligands显示文摘A new Co(II) metal-organic coordination polymer based on flexible bis(imidazole) and aromatic dicarboxylate co-ligands, namely [Co(bix)(nph)]n(H2nph = 3-nitrophthalic acid, bix = 1,4-bis(imidazole-1-ylmethyl)benzene), has been hydrothermally synthesized and characterized by elemental analyses, TG, IR spectroscopy and single-crystal X-ray diffraction. It crystallizes in the triclinic space group P1 with a = 9.3767(14), b = 10.1451(15), c = 12.1488(17), α = 102.6450(10), β = 108.856(2), γ = 98.807(2)°, V = 1035.3(3)3, Z = 2, C22H17 Co N5O6, Mr = 506.34, Dc = 1.624 g/cm3, μ = 0.882 mm-1 and F(000) = 518. In the complex, the nph2- ligands connect neighbouring cobalt atoms to form binuclear [Co(nph)]2 subunits, which are linked by pairs of bix ligands to form a 2D honeycomb-like(6,3) network. In addition, the compound is further extended into a 3D supramolecular architecture by π···π stacking interactions. Moreover, the luminescence and catalytic properties of the complex are investigated. | 张旭 葛明 HECKE Kristof Van 崔广华 | 2015 | Chinese Journal of Structural Chemistry2015，34，4： | 3 |
| 10 | Past,present and future of cyanide antagonism research:From the early remedies to the current therapies显示文摘This paper reviews milestones in antidotal therapies for cyanide(CN) spanning early remedies,current antidotal systems and research towards next generation therapies.CN has been a part of plant defense mechanisms for millions of years.It became industrially important in the nineteenth century with the advent of CN assisted gold mining and the use of CN as a pest control agent.The biochemical basis of CN poisoning was actively studied and key mechanisms were understood as early as 1929.These fundamental studies led to a variety of antidotes,including indirect CN binders that generate methemoglobin,direct CN binders such as hydroxocobalamin,and sulfur donors that convert CN to the less toxic thiocyanate.Research on blood gases at the end of the twentieth century shed new light on the role of nitric oxide(NO) in the body.The discovery of NO's ability to compete with CN for enzymatic binding sites provided a previously missed explanation for the rapid efficacy of NO generating antidotes such as the nitrites.Presently used CN therapies include:methemoglobin/NO generators(e.g.,sodium nitrite,amyl nitrite,and dimethyl aminophenol),sulfur donors(e.g.,sodium thiosulfate and glutathione),and direct binding agents [(e.g.,hydroxocobalamin and dicobalt salt of ethylenediaminetetraacetic acid(dicobalt edetate)].A strong effort is being made to explore novel antidotal systems and to formulate them for rapid administration at the point of intoxication in mass casualty scenarios.New antidotes,formulations,and delivery systems are enhancing bioavailability and efficacy and hold promise for a new generation of improved CN countermeasures. | Ilona Petrikovics Marianna Budai Kristof Kovacs David E Thompson | 2015 | World Journal of Methodology2015，5，2： | 3 |
| 11 | 模拟通过波罗的海一个沿海地区的水交换和污染物迁移显示文摘波罗的海海岸带的水交换特点是其随季节变化的特征。在对一个潜在的废核燃料埋藏点的安全评估中,重要的是评估假设的放射性核素从海底渗漏到水运阶段的后果。特别是,对相关的在近岸海岸带的滞留时间的估计值得注意。有若干种方法可以量化这样的估计,这里列举了其中的三种。利用(瑞典)Forsmark的沿海地点作为例子,将基于被动示踪物、颗粒轨迹以及外来水团的平均年龄分布的方法进行了典型的一年循环的比较。基于示踪物的方法可以比其他方法更逼真地模拟扩散性。以轨迹为基础的方法可以处理由于平流而产生的拉格朗日扩散过程,但忽略网格尺度的扩散。基于外来水平均年龄(AvA)概念的方法可同时包括所有这类来源,不仅是边界的水体,而且是各种(淡)水排泄。由于包含了亚网格的扩散,这种方法可以更顺利地测量水的更新。同时表明,时间轨迹和AvA时间的回溯基本上是相等的方法,在扩散率限定的范围内产生相关的结果。 | Anders Engqvist Kristofer Ds Oleg Andrejev 林宝法 | 2006 | AMBIO-人类环境杂志2006，35，8： | 3 |
| 12 | Infrared spectroscopic study of potassium and cesium acetate-intercalated kaolinites显示文摘 | Ray L Frost Oliver B Locos Janos Kristof J.Theo Kloprogge | 2001 | Vibrational Spectroscopy2001，，1： | 2 |
| 13 | Effect of water on the formamide-intercalation of kaolinite显示文摘 | Ray L Frost Janos Kristof Erzsebet Horvath J.Theo Kloprogge | 2000 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2000，，9： | 2 |
| 14 | Performance Analysis of Wavelength Converters Based on CrosssGain Modulation in Semiconductor-Optical Amplifiers显示文摘 | Kristof Obermann Stephan Kindt Dirk Breuer | 1998 | Journal of Lightwave Technology1998，16，1： | 1 |
| 15 | Low band gap donoracceptor conjugated polymers toward organic solar cells applications显示文摘 | Kristof C Sofie F Thomas J C | 2007 | Macromolecules2007，40，： | 1 |
| 16 | Negative-Pressure Wound Therapy and Laparoscopic Omentoplasty for Deep Sternal Wound Infections after Median Sternotomy显示文摘 | KRISTOF DE BRABANDERE MD DANIEL JACOBS-TULLE-NEERS-THEVISSEN MD JENS CZAPLA | 2012 | Tex Heart Inst J2012，39，3： | 1 |
| 17 | Strengthening outcomes of retailer–consumer relationships显示文摘 | Gaby Odekerken-Schr?der Kristof De Wulf Patrick Schumacher | 2003 | Journal of Business Research2003，，3： | 1 |
| 18 | Mechano-chemical treatment of kaolinite显示文摘 | Frost R L Mako E Kristof J Horvath E Theo-kloprogge J | 2001 | Journal of Colloid and Interface Science2001，239，： | 1 |
| 19 | Person-organization fit: An integrative re-view of its conceptualizations, measurement and impli-cations显示文摘 | Kristof A L | 1996 | Personnel Psychology1996，，49： | 1 |
| 20 | Design of an All-reflective Unobscured Optical-power Zoom Objective显示文摘 | Kristof Seidl Jens Knobbe Heinrich Gruger | 2009 | Ap-plied Optics2009，48，21： | 1 |
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