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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 4 | 载脂蛋白E及脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病、死亡风险的关系显示文摘膳食脂肪对心血管健康和死亡率的作用仍然存在争议。由于载脂蛋白E(apolipoprotein E,APOE)是脂质运输和代谢的核心,研究者通过检测APOE—ε4基因型,评估了血浆脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病(冠心病)、死亡风险之间的关系。 | 刘青 叶鹏 Satizabal CL Samieri C Davis-Plourde KL Voetsch B Aparicio HJ Pase MP Romero JR Helmer C Vasan RS Kase CS Debette S Beiser AS Seshadr Sudhai | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Molecular analysis of the root canal microbiota associated with endodontic treatment failures显示文摘 | Sakamoto M Siqueira JF Jr R(o)(c)as IN | 2008 | Oral Microbiol Immunol2008，23，4： | 1 |
| 7 | Phase I study of twodifferent schedules of bortezomib and pemetrexed in ad-vanced s olid tumors with emphasis on non-small cell lungcancer显示文摘 | Davies AM Ho C Metzger AS | 2007 | J Thorac Oncol2007，2，12： | 1 |
| 8 | Immunohis tochemincal detection of inducible nitric oxide synthase, nitroty rosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | STE-MARIE L HAZELL AS BEMEUR C | 2001 | Brain Res2001，918，： | 1 |
| 9 | Clinical experiences with magnetic drug targeting:a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors显示文摘 | Lubbe AS Bergemann C Riess H | 1996 | Cancer Res1996，56，20： | 1 |
| 10 | Low tear production in patients with diabetes mellitus is not due to SjOgren ' s syndrome 显示文摘 | Ramos-Remus C Suarez-Almazor M Russell AS | 1994 | Elin Exp Rheumatol1994，12，： | 1 |
| 11 | Presence of theiron exporter ferroportin at the plasma membrane of macro-phages is enhanced by iron loading and down^regulated byhepcidin 显示文摘 | Delaby C Pilard N Goncalves AS | 2005 | Blood2005，106，： | 1 |
| 12 | Endoscopic management of ce- sarean scar pregnancy显示文摘 | Wang C J Chao AS Yuen LT | 2006 | Fertility and Sterility2006，85，2： | 1 |
| 13 | Clinical and laboratory evaluation of a real-time PCR for Clostridium difficile toxin A and B genes显示文摘 | de Jong E de Jong AS Bartels C J | 2012 | Eur J Clin Microbiol Infect Dis2012，31，9： | 1 |
| 14 | Pain after percutaneous nephrolithotomy:impact of nephros-tomy tube size显示文摘 | PIETROW P K AUGE B K LALL AS C D | | 0，，06： | 1 |
| 15 | Glaucoma: informations for the general practitioner显示文摘 | Hirneiss C Neubauer AS | 2014 | MMW Fortschr Med2014，156，15： | 1 |
| 16 | Adjuvant effective as fluorouracil plusleucovorin for survival in people with resected stage III colon cancer 显示文摘 | Lamberti C Sauerbruch capecitabine is at least as T Glasmacher A | 2005 | Cancer Treat Rev2005，31，8： | 1 |
| 17 | Describing and quantifying asthma comorbidity: a popula-tion study显示文摘 | Gershon AS Guan J Wang C | 2012 | Plos One2012，7，34： | 1 |
| 18 | Stressful life-events, anxiety,depeession and coping in patients of irritable显示文摘 | Pinto C Lele MV Joglekar AS | 2000 | J Assoc Physicians India2000，48，6： | 1 |
| 19 | Significance of aberrant immunophenotypes in childhood acute lymphoid leukemia 显示文摘 | Kurec AS Belair P Stefanu C | 1991 | Cancer1991，67，12： | 1 |
| 20 | Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle显示文摘 | Canto C Jiang LQ Deshmukh AS | 2010 | Cell Metab2010，11，3： | 1 |
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