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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis显示文摘BACKGROUND To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM To determine the rate of LN metastases and its impact in survival in patients with GNEN1 in relation to certain clinico-pathological parameters. METHODS The PubMed, EMBASE, Cochrane Library, Web of Science and Scopus databases were searched through January 2019. The quality of the included studies and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) in accordance with the Cochrane guidelines. A random effects model and pooled odds ratios (OR) with 95%CI were applied for the quantitative meta-analysis. RESULTS We screened 2933 articles. Thirteen studies with 769 unique patients with GNEN1 were included. Overall, the rate of metastasis to locoregional LNs was 3.3%(25/769). The rate of LN metastases with a cut-off size of 10 mm was 15.3% for lesions > 10 mm (vs 0.8% for lesions < 10 mm) with a random-effects OR of 10.5 (95%CI: 1.4 -80.8;heterogeneity: P = 0.126;I2 = 47.5%). Invasion of the muscularis propria was identified as a predictor for LN metastases (OR: 17.2;95%CI: 1.8-161.1;heterogeneity: P = 0.165;I2 = 44.5%), whereas grade was not clearly associated with LN metastases (OR: 2;95%CI: 0.3-11.6;heterogeneity: P = 0.304;I2 = 17.4%). With regard to GNEN1 local recurrence, scarce data were available. The 5-year disease-specific survival for patients with and without LN metastases was 100% in most available studies irrespective of the type of intervention. Surgical resection was linked to a lower risk of recurrence (OR: 0.3;95%CI: 0.1-1.1;heterogeneity: P = 0.173;I2 = 31.9%). The reported complication rates of endoscopic and surgical intervention were 0.6 and 3.8%, respectively. CONCLUSION This meta-analysis confirms that tumor size ≥ 10 mm and invasion of the muscularis propria are linked to a higher risk of LN metastases in patients with GNEN1. Overall, the metastatic propensity of GNEN1 is low with favorable 5- year disease-specific survival rates reported;hence, no clear evidence of the prognostic value of LN positivity is available. Additionally, there is a lack of evidence supporting the prediction of local recurrence in GNEN1, even if surgery was more often a definitive treatment. | Apostolos V Tsolakis Athanasia Ragkousi Miroslav Vujasinovic Gregory Kaltsas Kosmas Daskalakis | 2019 | World Journal of Gastroenterology2019，25，35： | 6 |
| 3 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019，25，44： | 2 |
| 4 | Ethylene optimization system reaps operations and ma-intenance benefits显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil&Gas1998，，： | 1 |
| 5 | Ethylene optimization system reaps operations and ma- intenance benefits 显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil & Gas1998，，： | 1 |
| 6 | Influence of ferrous iron on the granularity of a UASB reactor显示文摘 | Apostolos V Elli M B Sofia M | 2009 | Chem Eng J2009，146，1： | 1 |
| 7 | Palatovaginal (pharyngeal) artery: clinical implication and surgical experience显示文摘 | Apostolos K Luca V Vincenzo A | 2014 | Eur Arch Otorhinolaryngol2014，271，10： | 1 |
| 8 | Discoloration ofazo dye acid red 18 by fenton reagent in the presence of iron powder显示文摘 | Apostolos V Elli M Sofia M | 2003 | Polish Journal of Environmental Studies2003，12，2： | 1 |
| 9 | Differential expression of MicroRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice显示文摘 | Dionysios V Chartoumpekis Apostolos Z | | 0，，04： | 1 |
| 10 | Electrochemical detoxification of four phosphorothioate obsolete pesticides stocks显示文摘 | APOSTOLOS V DIMITRIS A SOFIA M | 2005 | Chemosphere2005，，58： | 1 |
| 11 | Electrochemical detoxification of four phosphorothioate obsolete pesticides stocks显示文摘 | Apostolos V Dimitris A Sofia M | 2005 | Chemosphere2005，58，4： | 1 |
| 12 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells显示文摘 | Hadi V Karin E Apostolos B | 2007 | Nat Cell Biol2007，9，： | 1 |
| 13 | Build-ing Enterprise-wide Information Supply ChainsBased on the Fractal Concept显示文摘 | Patrick W Philippos K Apostolos V | 2003 | Integrated Manu-facturing Systems2003，14，5： | 1 |
| 14 | Ethylene optimization system reaps operations and maintenance benefits显示文摘 | Apostolos G H Ajit V S Paulsboro N J | | 0，，10： | 1 |
| 15 | Biomechanical properties of the scapholunate ligament and the importance of its portions in the capitate intrusion injury显示文摘 | Fotios V Emmanuel P Apostolos D | | 0，，： | 1 |
| 16 | Building enterprise-wide information supply chains based on the fractal concept显示文摘 | PATRICK W PHILIPPOS K APOSTOLOS V ADAMANTIOS K | 2003 | Integrated Manufacturing Systems2003，5，14： | 1 |
| 17 | Distribution of obestatin and ghrelin in human tissues:Immunoreactive cells in the gastrointestinal tract,pancreas,and mammary glands显示文摘 | Malin G Apostolos V Linda M | 2008 | J Histochem Cytochem2008，56，9： | 1 |
| 18 | Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1显示文摘 | Apostolo V Eugene O Shah | 2007 | Arterioscler Thromb Vasc Biol2007，27，4： | 1 |
| 19 | Ethylene optimization system reaps operations and maintenance benefits 显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil & Gas1998，，： | 1 |
| 20 | Ethylene optimization system reaps operations and ma-intenance benefits显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil&Gas1998，，： | 1 |
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