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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 3 | Utilization of a benchtop mass spectrometer with capillary supercritical fluid chromatography显示文摘 | MURUGAVERL B KENT J DE LUCA V S J | 1993 | Journal of Chromatography A1993，633，： | 1 |
| 4 | Analysis of the novel TPH2 gene in bipolar disorder and suicidality 显示文摘 | De Luca V Mueller D J Tharmalingam S | 2004 | Mol Psychiary2004，9，10： | 1 |
| 5 | Does the sverdrup critical depth model explain bloom dynamics in estuaries? 显示文摘 | Lucas L V Cloern J E Koseff J R | 1998 | Journal of Marine Research1998，56，： | 1 |
| 6 | Glial cell line-derived neurotrophic factor receptor alpha 2 ( GFRA2 ) gene is associated with tardive dyskinesia 显示文摘 | Souza RP de Luca V Remington G | 2010 | Psychopharmacology ( Bell)2010，210，： | 1 |
| 7 | Assemblies of glutamate receptor subtmits with post-synaptic density proteins and their alterations in parkinson's disease 显示文摘 | Gardoni F Ghiglieri V Luca M | 2010 | Prog Brain Res2010，183，： | 1 |
| 8 | Prognostic role of the cyclin-dependent kinase inhibitor p27 kip1 in non-small cell lung cancer显示文摘 | Esposito V Baldi A De Luca A | 1997 | Cancer Res1997，57，： | 1 |
| 9 | Bcl-xL antisense oligonucleotides chemosensitize human glioblastoma cells 显示文摘 | Guensberg P Wacheck V Lucas T | 2002 | Chemotherapy2002，48，4： | 1 |
| 10 | 查看详情显示文摘 | Marco de Lucas M C Fabreguette F Linsavanh M Imhoff L Heintz O Josse-Courty C Mesnier M T Potin V Bourgeois S Sacilotti M | | 0，，： | 1 |
| 11 | Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated indi- viduals: an analysis of the NACC database 显示文摘 | SPERING C C HOBSON V LUCAS J A | 2012 | J Gerontol A Biol Sci Med Sci2012，67，8： | 1 |
| 12 | Damage to the erectile function following radical pelvic surgery:prevalence of veno-occlusive dysfunction显示文摘 | De Luca V Pescatori ES Taher B | 1996 | Eur Urol1996，29，1： | 1 |
| 13 | Laboratory Diagnosis of Human Neurocysticercosis:Double-Blind Comparison of Enzyme-Linked Immunosorbent Assay and Electroimmuno-transfer Blot Assay显示文摘 | J V Proano Narvaez Antonio Meza Lucas Olga Mats Ruiz | 2002 | Journal of clinical microbiolo-gY2002，40，6： | 1 |
| 14 | Accuracy accessment of sattelite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEI V D | 1994 | Potogramatic Engineering & Remote Sensing1994，60，4： | 1 |
| 15 | The prediction of drug metabolism, tissue distribution and bioavail- ability of 50 structurally diverse compounds in rat using mechanism-based ADME prediction tools显示文摘 | De BS Sinha V Luca A | 2007 | Drug Metab Dispos2007，35，4： | 1 |
| 16 | Expression in Escherichia coli and partial characterization of two tyrosine/dopa decarboxylases from opium poppy 显示文摘 | Facchini PJ Luca V De | 1995 | Phytochemistry1995，38，： | 1 |
| 17 | Synthetic dyes decolourisation by White-rot fungi: development of original microtitre plate method and screening 显示文摘 | M Lucas V Mertens A-M Corbisier S Vanhulle | 2008 | Enzyme Microb Technol2008，42，2： | 1 |
| 18 | Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk显示文摘 | Sibilia V Pagani F Rindi G Lattuada N Rapetti D De Luca V et al | 2008 | Br J Pharmacol2008，154，： | 1 |
| 19 | Utilizntion of a benchtop mass spectrometer with capillary supercritical fluid chromatography显示文摘 | Murugaved B Kent J De Luca V S J | 1993 | Journal of Chromatography A1993，633，： | 1 |
| 20 | Expression of surface protein receptors in lung cancer显示文摘 | Esposito V Groeger AM De Luca L | 2002 | Anticancer Res2002，22，6： | 1 |
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