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| 1 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 2 | Urine versus brushed samples in human papillomavirus screening: study in both genders显示文摘瞄准:调查尿是否是屏蔽的好媒介并且是否在提取 DNA 和人的乳头状瘤病毒(HPV ) 的数量之间有关联确实。方法:从 HPV 积极的病人,和 31 个 FVU 标本和从 HPV 积极的女人与宫颈刷子取样的 100 基于液体的宫颈细胞学剩余物的男搭挡在现在的学习, 30 个第一虚空的尿(FVU ) 标本和 20 个 urethroglandular 拖把使用 cervex 刷为β - 滴的存在被检验在里面。Oncogenic HPV 用类型特定的 PCR 被检测。结果:β - 滴在在所有刷的样品被发现,而它被发现在仅仅 68.9% FVU 标本。HPV-PCR 在 60.0% 男刷子是积极的,在 29% 女刷子。分别地, DNA 集中是 0.9998 ng/μ L, 37.0598 ng/μ L 和 0.0207 ng/μ L。结论:尿不是为 HPV 察觉的一个好工具,可能因为低 DNA 集中反映低数量收集了房间。β - 滴在在由实时量的 PCR 的 FVU 是可测量的,但是 DNA 集中与为两性的刷子采样相比是更低的。尿道、颈的拖把的β -globin 确实是 100% ,显示出 DNA 的更高吝啬的集中,导致 HPV 的更高的察觉率。这是连接 DNA 集中到 HPV 的存在的第一篇文章。 | Kathleen D'Hauwers Christophe Depuydt John-Paul Bogers Michel Stalpaert Annie Vereecken Jean-Jacques Wyndaele Wiebren Tjalma | 2007 | Asian Journal of Andrology2007，9，5： | 3 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 5 | Fish evidence of uncoupling protein 3 gene显示文摘 | Marie D Annie V Assunta L | 2000 | Gene2000，246，： | 1 |
| 6 | Immunoglobulin coating of faecal bacteria in inflammatory bowel disease显示文摘 | Laurens A van der Waaij Frans GM Kroese Annie Visser Gerardus F Nelis Bram D Westerveld Peter LM Jansen John O Hunter | 2004 | European Journal of Gastroenterology & Hepatology2004，，7： | 1 |
| 7 | The Proinfammatory actions of Angiotensin Ⅱ are Dependent on p65 phosphorylation by the 1κB kinase complex显示文摘 | Annie D Annie BP Simon G | 2006 | J Biol Chem2006，281，13： | 1 |
| 8 | Serotonin at the laterodorsal tegmental nucleus suppresses rapid-eye-movement sleep in freely behaving rats显示文摘 | Horner RL Sanford LD Annis D | 1997 | J Neurosci1997，17，19： | 1 |
| 9 | Increased expression of 'peripheraltype' benzodiazepine receptors in human temporal lobe epilepsy:implications for PET imaging of hippocampal sclerosis显示文摘 | Anny S Paul D Violina L | 2002 | Metabol Brain Dis2002，17，1： | 1 |
| 10 | Polymer - supported chiral Co (salen) complexes : Synthetic applications and mechanis- tic investigations in the hydrolytic kinetic resolution of ter- minal epoxides 显示文摘 | Annis D A Jacobsen E N | 1999 | J Am Chem Soc1999，121，17： | 1 |
| 11 | Release and regeneration of protoplasts from the fungus Trichothecium roseum显示文摘 | N Balasubramanian G Annie Juliet P Snkalaivani D Lalithakumari | 2003 | Canadian Journal of Microbiology2003，49，： | 1 |
| 12 | Variability of integrin α2β1 activity on human platelets显示文摘 | Kunicki TJ Orchekowski R Annis D | 1993 | Blood1993，82，： | 1 |
| 13 | Task Force 1: the changing profile of congenital heart disease in adult life显示文摘 | Carole A Warnes Richard Liberthson Gordon K Danielson Annie Dore Louise Harris Julien I.E Hoffman Jane Somerville Roberta G Williams Gary D Webb | 2001 | Journal of the American College of Cardiology2001，，5： | 1 |
| 14 | Sperm cells of Zea mays have a complex complement of mRNAs显示文摘 | Engel M L Annie C Christian D | 2003 | Plant Journal2003，34，5： | 1 |
| 15 | ADAMTS-1 mediates the release of antiangiogenic polypeptides from TSP1 and 2显示文摘 | LEE N V SATO M ANNIS D S | 2006 | EMBO J2006，25，22： | 1 |
| 16 | Prognostic factors in women treated for ovarian yolk sac tumour: A retrospective analysis of 84 cases显示文摘 | Thibault de La Motte Rouge Patricia Pautier Annie Rey Pierre Duvillard Pierre Kerbrat Frédéric Troalen Philippe Morice Christine Haie-Meder Stéphane Culine Catherine Lhommé | 2010 | European Journal of Cancer2010，，2： | 1 |
| 17 | A Contextual Theory of Epistemic Justification显示文摘 | ANNIS D B | 1978 | American Philosophical Quarterly1978，，15： | 1 |
| 18 | The discovery of indoxaearb: oxadiazines as a new class of pyrazoline type insecticides显示文摘 | MCCANN S F ANNIS G D SHAPIRO R | 2001 | Pest Manag Sci2001，57，2： | 1 |
| 19 | ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 显示文摘 | LEE N V SATO M ANNIS D S | 2006 | EMBO J2006，25，22： | 1 |
| 20 | Mitoehondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulln-resistant mice显示文摘 | Charlotte B Annie D Simone P | 2008 | J Clin Invest2008，118，2： | 1 |
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