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| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Unveiling the enigma of refractory carbon in the ocean显示文摘INTRODUCTION The ocean holds a tremendous reservoir of refractory dissolved organic carbon (RDOC)that plays an important role in carbon cycling and climate change [1].However,the origin of the RDOC has been an enigma for half a century. This perspective is to address why the enigma deserves scientific efforts and illustrate a robust scheme--the Microbial Carbon Pump (MCP)-to unveil the enigma from molecular to ecosystem levels,Through generation of intrinsic RDOC (RDOCt)under specific biotic and abiotic environmental conditions,as well as through derivation of diverse organic molecules at extremely low concentrations (RDOCc). | Nianzhi Jiao Ruanhong Cai Qiang Zheng Kai Tang Jihua Liu Fanglue Jiao Douglas Wallace Feng Chen Chao Li Rudolf Amann Ronald Benner Farooq Azam | 2018 | National Science Review2018，5，4： | 10 |
| 3 | Galvanically induced potentials to enable minimal tribochemical wear of stainless steel lubricated with sodium chloride and ionic liquid aqueous solution显示文摘The effect of galvanically induced potentials on the friction and wear behavior of a 1 RK91 stainless steel regarding to tribocorrosion was investigated using an oscillating ball-on-disk tribometer equipped with an electrochemical cell. The aim of this investigation is to develop a water-based lubricant. Therefore 1 molar sodium chloride(NaCl) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl] water solutions were used. Tribological performance at two galvanically induced potentials was compared with the non-polarized state: cathodic potential-coupling with pure aluminum- and anodic potential-coupling with pure copper. Frictional and electrochemical response was recorded during the tests. In addition, wear morphology and chemical composition of the steel were analyzed using scanning electron microscopy(SEM) and X-ray photoelectron spectroscopy(XPS), respectively. The galvanically induced cathodic polarization of the stainless steel surface results in electrochemical corrosion protection and the formation of a tribolayer. Cations from the electrolyte(sodium Na^+ and 1-ethyl- 3-methylimidazolium [C_2 mim]^+) interact and adhere on the surface. These chemical interactions lead to considerably reduced wear using 1 NaC l(86%) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl](74%) compared to the nonpolarized system. In addition, mechanical and corrosive part of wear was identified using this electrochemical technique. Therefore this method describes a promising method to develop water-based lubricants for technical applications. | Tobias AMANN Felix GATTI Natalie OBERLE Andreas KAILER Jürgen RüHE | 2018 | Friction2018，6，2： | 7 |
| 4 | Tests to measure the quality of spermatozoa at spermiation显示文摘这评论到评论修订世界健康组织() 象它用手的精液分析在 spermiation 与一个精子的特征相关。目的修订用手没有任何限制,包括改进“精液分析的质量”到临床的使用。而且,手册声明精液分析可能为(a) 是有用的“调查男富饶地位”和(b) “监视精子发生在期间并且跟随男富饶规定。“如果呼喊的精子的分析为在(b) 描述的目的被打算,那么,在 spermiation 是反常的房间不管多么必须被识别。这份报纸拿手册不识别的位置在 spermiation 估计精子的质量的方法。相反,它使用通过颈的粘液或在授精的地点附近到达的精子的一个“标准答案”。尽管这个标准为画考虑一个个人能使妊娠的概率的结论他的搭挡是适当的,它不为学习睾丸本身的病是适当的。此处,在 WHO 手册介绍的精子质量的措施是关于在随后变得反常的 spermiation 对那些是反常的精子的察觉的 critiqued。优秀评价基于能动或“可行”的精子的百分比是无意义的。在 spermiation 定义精子的其他的优秀属性在这份报纸被介绍。在结论,根据单个呼喊的精子的优秀属性,对在 spermiation 的精子的质量的评价最好通过(a)的申请被完成为精子质量和(b)的词法评估的一个新范例评估的现代分析技术在一件足够的样品,在每个精子的几个适当独立属性以便更精确地识别反常精子的比例。 | Rupert P. Amann | 2010 | Asian Journal of Andrology2010，12，1： | 5 |
| 5 | 亚洲东北部的能源消耗和酸沉降显示文摘亚洲在北部是世界上最有生气的地区之一,又是地区内各部分情况很不相同的地区之一。由于人口快速增长和充满活力的经济,能源消耗现在已占世界总量的12%,预计到2030年还将增加1~2倍。因为本区的能源大部分由矿物燃料供给,预计二氧化硫的排放量将以同样速度增长。中国东北部是硫的主要排放地区,排放出的硫向东迁移,越过朝鲜半岛到达日本甚至更远的地方。酸沉降已很明显,将来会增加得更快。如果不采取控制措施,整个地区的生态系统将被严重破坏。到2030年减少排放每年将花费100~300亿美元,而且仍只能做到部分控制。急需开展区域合作以提高我们对此问题的科学认识,为制定区城控制策略提供依据。 | David G.Streets Gregory R.Carmichael Markus Amann Richard L.Arndt 张淑贞 | 1999 | 人类环境杂志1999，28，2： | 5 |
| 6 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 7 | Widely tunable 2.3μm III-V-on-silicon Vernier lasers for broadband spectroscopic sensing显示文摘Heterogeneously integrating III-V materials on silicon photonic integrated circuits has emerged as a promising approach to make advanced laser sources for optical communication and sensing applications. Tunable semiconductor lasers operating in the 2–2.5 μm range are of great interest for industrial and medical applications since many gases(e.g., CO_2, CO, CH_4) and biomolecules(such as blood glucose) have strong absorption features in this wavelength region. The development of integrated tunable laser sources in this wavelength range enables low-cost and miniature spectroscopic sensors. Here we report heterogeneously integrated widely tunable III-V-on-silicon Vernier lasers using two silicon microring resonators as the wavelength tuning components. The laser has a wavelength tuning range of more than 40 nm near 2.35 μm. By combining two lasers with different distributed Bragg reflectors, a tuning range of more than 70 nm is achieved. Over the whole tuning range, the side-mode suppression ratio is higher than 35 dB. As a proof-of-principle, this III-V-on-silicon Vernier laser is used to measure the absorption lines of CO. The measurement results match very well with the high-resolution transmission molecular absorption(HITRAN) database and indicate that this laser is suitable for broadband spectroscopy. | RUIJUN WANG STEPHAN SPRENGEL ANTON VASILIEV GERHARD BOEHM JORIS VAN CAMPENHOUT GuY LEPAGE PETER VERHEYEN ROEL BAETS MARKUS-CHRISTIAN AMANN GUNTHER ROELKENS | 2018 | Photonics Research2018，6，9： | 3 |
| 8 | An abdominal and thyroid status with Acoustic Radiation Force Impulse Elastometry – A feasibility study显示文摘 | R.S. Goertz K. Amann R. Heide T. Bernatik M.F. Neurath D. Strobel | 2010 | European Journal of Radiology2010，，3： | 2 |
| 9 | A multifunctional rock testing system for rock failure analysis under different stress states: Development and application显示文摘The stress state in a rock mass is complex. Stress redistribution around underground excavation may lead to various failure modes, including compressive-shear, tensile-shear, and tensile failures. The ability to perform laboratory tests with these complex stress states is significant for establishing new strength criteria. The present paper introduces a new rock testing system with “tensile-compressive-shear”loading functions. The device includes bi-directional and double-range hydraulic cylinders, auxiliary loading equipment, and roller rows that can perform direct compressive-shear tests, direct tensile tests,and direct tensile-shear tests. The testing system provides maximum vertical and lateral loading forces of2000 k N and allows testing cubical rock specimens with dimensions of 0.5 m × 0.5 m × 0.5 m. The performance of the testing machine was evaluated by testing a rock-like material based on cement mortar under compressive-shear, tensile, and tensile-shear stress states. The failure process and deformation characteristics were monitored during loading using acoustic emission(AE) transient recorder,piezoelectric AE sensors, a high-speed camera, and a thermal infrared camera. The failure mechanism was investigated by analyzing AE counts, AE amplitude, strain, and temperature changes on the rock specimen surface. The test results confirmed that the testing system could successfully simulate the abovementioned stress path. The AE counts and amplitude responses were influenced by different failure modes. The temperature response during the compressive-shear test indicated the development of a high-temperature band on the rock specimen surface. In contrast, a negligible temperature change was observed during the tensile and tensile-shear tests. The newly developed multifunctional rock testing system allows laboratory tests under various failure modes. The monitoring results of multiple variables during rock failure tests provide valuable information on failure characteristics. | Shucai Li Jie Hu Florian Amann Liping Li Hongliang Liu Shaoshuai Shi Pooya Hamdi | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 2 |
| 10 | Anti-inflammatory effects of aspirin and sodium salicylate显示文摘 | Amann R Peskar BA | 2002 | Eur J Pharmacol2002，447，1： | 2 |
| 11 | Detection of PAHs in seawater using surface-enhanced Raman scattering (SERS)显示文摘 | Heinar Schmidt Nguyen Bich Ha Jens Pfannkuche Hans Amann Heinz-Detlef Kronfeldt Grazyna Kowalewska | 2004 | Marine Pollution Bulletin2004，，3： | 2 |
| 12 | Quasilinear parabolic systems under nonlinear boundary conditions显示文摘 | Herbert Amann | 1986 | Archive for Rational Mechanics and Analysis1986，，2： | 2 |
| 13 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 14 | 船只排放物对欧洲空气质量及酸性沉降造成的影响显示文摘一个名为'STOCHEM'的三维拉氏化学传输模型被用于描述2000年气候条件下国际海运活动产生的SO_2、NO_x、VOCs和CO排放造成的欧洲大西洋沿岸区域性酸性沉降和臭氧空气质量影响的状况。该模型得出的从西南海域到不列颠群岛和布列塔尼水域国际海运活动产生的硫沉降总量高达200mg/m^2·a。夏季国际海运活动对表层臭氧浓度的影响在爱尔兰、布列塔尼和葡萄牙高达约6ppb。在欧洲,海运活动产生的排放物是一种对酸性沉降和臭氧空气质量造成影响的外部因素,并且如果要在将来达到严格的沉降及空气质量目标,就需要采取一系列控制措施。 | Richard G.Derwent David S.Stevenson Ruth M.Doherty William J.Collins Michael G.Sanderson Colin E.Johnson Janusz Cofala Reinhard Mechler Markus Amann Frank J.Dentener 许天虎 | 2005 | AMBIO-人类环境杂志2005，34，1： | 2 |
| 15 | A multiplicity result for a class of elliptic boundary value problem显示文摘 | | 1979 | Proc Roy Soc Edin1979，80，： | 1 |
| 16 | Glutl expression is increased in hepatocellular and promotes tumorigenesis 显示文摘 | AMANN T MAEGDEFRAU U HARTMANN A | 2009 | Am J Pathol2009，174，4： | 1 |
| 17 | Issues affecting commercialization of sexed sperm显示文摘 | Amann RP | 1999 | Theriogenology1999，52，： | 1 |
| 18 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation显示文摘 | Amann R I Ludwig W Schleifer K H | 1995 | Microbiol Rev1995，59，： | 1 |
| 19 | Actinobacterial 16S rRNA genes from freshwater habitats cluster in four distinct lineages显示文摘 | Warnecke F Amann R Pernthaler J | 2004 | Environ Microbiol2004，6，3： | 1 |
| 20 | The trace amine receptor 4gene is not associated with schizophrenia in a sample linked to chromosome 6q23显示文摘 | Amann D Avidan N Kanyas K | 2006 | Mol Psychiatry2006，11，2： | 1 |
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