|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunopathogenesis of chronic hepatitis B显示文摘Chronic hepatitis B(CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus(HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special attention to the replication capacity of HBV in host cells, which is associated with cellular changes that reflect presentation of viral antigens and variability of HBV antigen features. In addition, specific HBV proteins have an immune-modulating ability to initiate molecular mechanisms that 'avoid' control by the immune system. The relationship between immunological shifts and chronic infection stages has been intensively studied since it was recognized that the immune system is a direct participant in the recurrent(cyclic) nature of CHB. Understanding the wide diversity of molecular pathways and the crosstalk between innate and adaptive immune system components will provide fresh insight into CHB immune pathogenesis and the possibilities of developing new treatment strategies for this disease. | Irina P Balmasova Nikolay D Yushchuk Ospan A Mynbaev Nageswara R Alla Elena S Malova Zhongjie Shi Chang-Lu Gao | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | The Muruntau gold deposit(Uzbekistan)--A unique ancient hydrothermal system in the southern Tien Shan显示文摘The Muruntau gold deposit in the Central Kyzylkum,Uzbekistan is one of the largest single gold deposits worldwide.Data available from the literature are reviewed with the aim to(1) integrate the present knowledge on this unique deposit from Russian and English literature;(2) show the considerable progress made in the understanding of the genesis of the Muruntau deposit during the last decades;and(3) point to problems still open for future research.Deposit formation occurred through a multi-stage process involving sedimentation,regional metamorphism including thrusting,magmatism with formation of hornfels aureoles and several stages of hydrothermal activity.According to recent knowledge,synsedimentary or pure metamorphic formation of gold mineralization seems unlikely.The role of granite magmatism occurring roughly within the same time interval as the main hydrothermal gold precipitation remains uncertain.There are no signs of interaction of matter between the magma(s) and the hydrothermal system(s).On the other hand,there was an intense,high-temperature(above 400 ℃)fluid- wall rock interaction resulting in the formation of gold-bearing,cone-like stockworks with veins,veinlets and gold-bearing metasomatites.Several chemical and isotope indicators hint at an involvement of lower-crustal or mantle-related sources as well as of surface waters in ore formation.Deposit formation through brecciation involving explosion,hydrothermal or tectonic breccias might explain these data.Further investigations on breccia formation as well as on the exact timing of relevant sedimentary,metamorphic,magmatic and hydrothermal events are recommended. | Ulf Kempe Torsten Graupner Reimar Seltmann Hugo de Boorder Alla Dolgopolova Maarten Zeylmans van Emmichoven | 2016 | Geoscience Frontiers2016，7，3： | 7 |
| 3 | 机械化学法制备的Al/Ce复合氧化物负载NiMo催化剂的加氢脱硫活性(英文)显示文摘将Al和/或Ce的硝酸盐与NH_4HCO_3球磨混合,采用机械化学法制备了Al_2O_3-CeO_2载体(其中Ce含量为1-10 wt%),再以杂多钼酸盐(NH_4)_4NiMo_6O_(24)为活性金属Ni和Mo的前驱体,通过浸渍法制备NiMo_6/Al_2O_3-CeO_2催化剂,并将其用于1-苯并噻吩(BT)的加氢脱硫(HDS)反应中.运用化学分析、X射线衍射、N_2吸附-脱附法、H_2程序升温还原、NH_3程序升温脱附和X射线光电子能谱对催化剂的物化性质进行了表征.结果表明,催化剂的酸性随着载体中Ce含量的增加而下降.Ce修饰的Al_2O_3载体表面的NiS/MoS原子比下降了2倍.NiMo_6/Al_2O_3催化剂表现出最高的HDS活性(以单位重量催化剂计),其酸性和表面MoO_xS_y物种的浓度(Mo^(5+)浓度)也最高;当催化剂中Ce含量逐渐增加到10 wt%以上时,其活性逐渐将为0.与浸渍法制得的参比催化剂相比,前驱体和催化剂组成相同的情况下,采用机械化学法制得的所有催化剂活性明显提高. | Květa Jirátová Alla Spojakina Luděk Kaluza Radostina Palcheva Jana Balabánová Georgi Tyuliev | 2016 | Chinese Journal of Catalysis2016，37，2： | 6 |
| 4 | 镍钼杂多酸制备NiMo/γ-Al_2O_3催化剂及硼、钴或镍改性氧化铝的影响(英文)显示文摘A hydrotreating NiMo/γ-Al2O3 catalyst(12 wt% Mo and 1.1 wt% Ni) was prepared by impregnation of the support with the Anderson-type heteropolyoxomolybdate(NH4)4Ni(OH)6Mo6O18.Before impregnation of the support,it was modified with an aqueous solution of H3BO3,Co(NO3)2,or Ni(NO3)2.The catalysts were investigated using N2 adsorption,O2 chemisorption,X-ray diffraction,UV-Vis spectroscopy,Fourier transform infrared spectroscopy,temperature-programmed reduction,temperature-programmed desorption,and X-ray photoelectron spectroscopy.The addition of Co,Ni,or B influenced the Al2O3 phase composition and gave increased catalytic activity for 1-benzothiophene hydrodesulfurization(HDS).X-ray photoelectron spectroscopy confirmed that the prior loading of Ni,Co or B increased the degree of sulfidation of the NiMo/γ-Al2O3 catalysts.The highest HDS activity was observed with the NiMo/γ-Al2O3 catalyst with prior loaded Ni. | Radostina PALCHEVA Luděk KALUZA Alla SPOJAKINA Květue JIRTOV Georgi TYULIEV | 2012 | 催化学报2012，33，6： | 6 |
| 5 | New insights into renal lipid dysmetabolism in diabetic kidney disease显示文摘Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the kidney.Research suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell death.Therefore,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be archived.This article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD. | Alla Mitrofanova George Burke Sandra Merscher Alessia Fornoni | 2021 | World Journal of Diabetes2021，12，5： | 5 |
| 6 | Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis显示文摘Nonalcoholic fatty liver disease(NAFLD)remains a leading cause of chronic liver disease.In the context of NAFLD,the presence of nonalcoholic steatohepatitis (NASH)portends an adverse prognosis with greater risk of liver fibrosis and cirrhosis.Although liver biopsy is the keystone of patient management in NAFLD,it is also increasingly clear that such evaluation has its limitations.The availability of biochemical markers of NAFLD and NASH has tremendous potential to radically alter management strategies for these conditions,as well as to monitor disease activity.Our article provides an overview of biomarker discovery and selection in the setting of NAFLD and highlights future directions in the field. | Yusuf Yilmaz Alla Eldeen Kedrah Osman Ozdogan | 2009 | World Journal of Gastroenterology2009，15，35： | 4 |
| 7 | Serrated lesions:A challenging enemy显示文摘The serrated pathway accounts for 30%-35%of colorectal cancer(CRC).Unlike hyperplastic polyps,both sessile serrated lesions(SSLs)and traditional serrated adenomas are premalignant lesions,yet SSLs are considered to be the principal serrated precursor of CRCs.Serrated lesions represent a challenge in detection,classification,and removal–contributing to post-colonoscopy cancer.Therefore,it is of the utmost importance to characterize these lesions properly to ensure complete removal.A retrospective cohort study developed a diagnostic scoring system for SSLs to facilitate their detection endoscopically and subsequent removal.From the study,it can be ascertained that both indistinct border and mucus cap are essential in both recognizing and diagnosing serrated lesions.The proximal colon poses technical challenges for some endoscopists,which is why high-quality colonoscopy plays such an important role.The indistinct border of some SSLs poses another challenge due to difficult complete resection.Overall,it is imperative that gastroenterologists use the key features of mucus cap,indistinct borders,and size of at least five millimeters along with a high-quality colonoscopy and a good bowel preparation to improve the SSL detection rate. | Alexa Trovato Alla Turshudzhyan Micheal Tadros | 2021 | World Journal of Gastroenterology2021，27，34： | 3 |
| 8 | TNF-α gene polymorphisms: association with age-related macular degeneration in Russian population显示文摘AIM: To study polymorphisms in promotor regions of tumor necrosis factor(TNF)-α TNF-863 A/C(rs1800630), TNF-308 A/G(rs1800629), and TNF-238 A/G(rs361525) in patients with age-related macular degeneration(AMD) and associations of complex TNF-α genotypes with AMD. METHODS: One hundred and two patients(82 women, 20 men; mean age 64.2±1.2 y) with AMD and 100 healthy age-and sex-matched controls(82 women, 18 men; 60±1.4 y) were included in the study. All subjects were Caucasian, all subjects and their parents were inhabitants of Russia. Genomic DNA was obtained from EDTA-preserved blood using the standard phenol-chloroform method. Polymorphisms were detected by polymerase chain reaction followed by the restriction fragment length polymorphism method. The following TNF-α genotypes were studied: TNF-α-238 AA, GA, GG, TNF-α-308 AA, GA, GG, TNF-α-863 AA, CA, CC. RESULTS: Differences in TNF-α-863 and TNF-α-238 genotypes frequencies in patients with AMD and healthy controls were not found. The distribution of TNF-α-308 AA and TNF-α-308 GA genotypes was significantly different between the studied group and the controls [odds ratios(OR) =0.22, P=0.0287 and OR=2.91, P=0.0063, respectively]. TNF-863 CC/TNF-308 GA and TNF-308 GA/TNF-238 GG genotypes were associated with the increased risk of AMD(OR=2.48, P=0.0332 and OR=2.51, P=0.0187, respectively). Five genotypes combinations appeared to be protective. CONCLUSION: In the present study, single nucleotide polymorphisms and complex polymorphisms of one of the key inflammatory cytokines TNF-α, and a number of significant associations of these polymorphisms with AMD in Russian population have been shown. Complexanalysis of genotypes could be important in AMD risk factors detection and studying pathogenesis. | Valeriy Chernykh Alla Shevchenko Vladimir Konenkov Viktor Prokofiev Alena Eremina Alexander Trunov | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 2 |
| 9 | An unsolved conundrum: the ideal follow-up strategy after curative surgery for colorectal cancer显示文摘 | Piriyah Sinclair Anjana Singh Amjid A. Riaz Alla Amin | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 10 | Selection of phages and conditions for the safe phage therapy against Pseudomonas aeruginosa infections显示文摘The emergence of multidrug-resistant bacterial pathogens forced us to consider the phage therapy as one of the possible alternative approaches to treatment. The purpose of this paper is to consider the conditions for the safe, long-term use of phage therapy against various infections caused by Pseudomonas aeruginosa. We describe the selection of the most suitable phages, their most effective combinations and some approaches for the rapid recognition of phages unsuitable for use in therapy. The benefi ts and disadvantages of the various different approaches to the preparation of phage mixtures are considered, together with the specifi c conditions that are required for the safe application of phage therapy in general hospitals and the possibilities for the development of personalized phage therapy. | Victor Krylov Olga Shaburova Elena Pleteneva Sergey Krylov Alla Kaplan Maria Burkaltseva Olga Polygach Elena Chesnokova | 2015 | Virologica Sinica2015，30，1： | 2 |
| 11 | A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena显示文摘The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this phenomenon.The intracoronary administration of alteplase has been found to have no effect on the occurrence of MVO in patients with acute myocardial infarction.Consequently,the major events preceding the appearance of MVO in coronary arteries are independent of microthrombi,platelets,and neutrophils.Endothelial cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary arteries.However,reperfusion triggers more pronounced damage,possibly mediated by pyroptosis.MVO and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial remodeling.Therefore,pharmacological agents used to treat MVO should prevent endothelial injury and induce relaxation of smooth muscles.Ischemic conditioning protocols have been shown to prevent MVO,with L-type Ca2+channel blockers appearing the most effective in treating MVO. | Leonid N.Maslov Natalia V.Naryzhnaya Sergey V.Popov Alexandr V.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey V.Krylatov Feng Fu Jianming Pei Vyacheslav V.Ryabov Evgenii V.Vyshlov Svetlana V.Gusakova Alla A.Boshchenko Akpay Sarybaev | 2023 | The Journal of Biomedical Research2023，37，4： | 2 |
| 12 | Persistently Rising Alpha-fetoprotein in the Diagnosis of Hepatocellular Carcinoma:A Review显示文摘Hepatocellular carcinoma(HCC),one of the most common malignant tumors worldwide,is known for its grim prognosis,with untreated life expectancy being only a matter of months after the diagnosis.The difficulty in making a diagnosis early is one of the main contributing factors to the poor prognosis.Alpha-fetoprotein(AFP)had long been used as a surveillance tool,but suboptimal specificity and sensitivity has prompted liver societies to abandon the recommendation for its universal use,even in combination with ultrasonography.Most studies have shown no obvious correlation between serum AFP level and HCC tumor size,stage,or survival post-diagnosis.However,some studies concluded that a gradual rise or persistent elevation in AFP were positive predictors for tumor development.Other studies reported a fall in AFP followed by a rise in patients with HCC as well as persistently rising AFP levels without development of HCC on follow up.Our calculation of the sensitivity and specificity of persistently rising AFP for HCC were both low,at 60%and 35.8%,respectively,indicating that the presence of persistently rising AFP per se did not offer diagnostic benefit.In addition,our calculated mean slopes of persistently rising AFP levels in HCC and non-HCC patients were numerically very different,but the difference was not statistically significant.We conclude that the published data do not support a role for rising AFP levels per se in the diagnosis of HCC. | Alla Turshudzhyan George Y.Wu | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 2 |
| 13 | Material-aware mesh deformations显示文摘 | Tiberiu Popa Dan Julius Alla Sheffer | 2006 | Proceedings of Shape Modelling International Matsushima Japan June2006，14，16： | 1 |
| 14 | Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure:insights from the randomized aldactone evaluation study (RALES)显示文摘 | Zannad F Alla F Dousset B | 2000 | Circulation2000，102，11： | 1 |
| 15 | Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure:insights from the randomized aldactone evaluation study (RALES)显示文摘 | Zannad F Alla F Dousset B | 2000 | Circulation2000，102，22： | 1 |
| 16 | On fuzzy non-continuous mappings显示文摘 | MASHOUR A S GHANIM M H FATH ALLA M A | 1986 | Bull Calcutta Math Soc1986，，78： | 1 |
| 17 | Familial autosomal dominant sensorineural hearing loss associated with dilated cardiomyopathy显示文摘 | Kaushik M Alla VM Madan R | 2010 | South Med J2010，103，12： | 1 |
| 18 | Prolonged QTo intervaland torsades de pointes induced by citalopram 显示文摘 | Deshmukh A Ulveling K Alla V | 2012 | Tex Heart InstJ2012，39，1： | 1 |
| 19 | Petri nets for modeling of dynamic systems-a survey 显示文摘 | ALLA H | 1994 | Automatica1994，30，2： | 1 |
| 20 | Omenn syndrome with mutation in RAG1 gene显示文摘 | Jaouad IC Ouldim K Ali Ou Alla S | 2008 | Indian J Pediatr2008，75，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员