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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 4 | Metabolic andnutritional profile of obese adolescents with nonalcoholic fattyliver disease显示文摘 | De-Piano Aline Prado W L Caranti D A | 2007 | J Pediatr Gastroenterol Nutr2007，44，4： | 1 |
| 5 | Frequent deletions and down regulation of micro-RNA genes miR15 and miR16 at 13ql4 in chronic lymphocytic leukemia 显示文摘 | ALIN G A DUMITRU C D SHIMIZU M | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 6 | Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids显示文摘 | Débora Estadella Claudia M. da Penha Oller do Nascimento Lila M. Oyama Eliane B. Ribeiro Ana R. Damaso Aline de Piano Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 7 | Insights into colloid-mediated trace element release at the soil/water interface显示文摘 | Mathieu P Aline D Melanie D | 2008 | Journal of Colloid and Interface Science2008，325，： | 1 |
| 8 | FOSL2 promotes leptin gene expression in human and mouse adipocytes显示文摘 | Wrann Christiane D Eguchi Jun Bozec Aline Xu Zhao Mikkelsen Tarjei Gimble Jeffrey Nave Heike Wagner Erwin F Ong Shao-En Rosen Evan D | 2012 | EN2012，，3： | 1 |
| 9 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyika, Africa显示文摘 | O'REILLY C M ALIN S R PLISNIER P D | 2003 | Nature2003，424，6950： | 1 |
| 10 | Adjuvant chemotherapy for radically resected non-small cell lung cancer:A retrospective analysis of 311 consectively treated patients显示文摘 | Teodor H Alin T | 2005 | Lung Cancer2005，47，1： | 1 |
| 11 | Climate changedecreases aquatic ecosystem productivity of Lake Tanganyika,Africa显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
| 12 | Frequent deletions and down reguJation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia显示文摘 | Alin G A Dumitru C D Shimizu M | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 13 | Aggregation methods for largescale sensor networks 显示文摘 | LAUKIK C S ALIN D SAN JAY R | 2008 | ACM Trans on Sensor Networks2008，4，2： | 1 |
| 14 | Dimethylsulphoxide and other biogenie sulphur compounds in the Galapagos Plume 显示文摘 | HATTON A D TURNER S M M ALIN G | 1998 | Deep-Sea Research Ⅱ1998，45，： | 1 |
| 15 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyi- ka, Africa 显示文摘 | O' Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，： | 1 |
| 16 | Localized hyperhldrosis treated with aluminum chloride in a salicylic acid in a salicylic acid gel ase显示文摘 | Antranik B Alin D Chantal B | 1998 | Int J Dermatology1998，37，9： | 1 |
| 17 | Factorization of Hardy spaces and Hankel operators on convex domains in ? n显示文摘 | Aline Bonami Marco M. Peloso Frédéric Symesak | 2001 | The Journal of Geometric Analysis2001，，3： | 1 |
| 18 | Brorninated flame retar- dants and polyehlorinated biphenyls in fish from the river显示文摘 | Laurence R Alin C D Geert G | 2008 | Environment International2008，34，： | 1 |
| 19 | Insights into colloid-mediated trace element release at the soil/water interface显示文摘 | Mathieu P Aline D Melanie D | 2008 | Journal of Colloid and Interface Science2008，325，： | 1 |
| 20 | Release of Trace Elements in Wetlands: Role of Seasonal Variability显示文摘 | GWENAELLE O L GERARD G ALINE D et 02 | 2001 | Water Research2001，35，4： | 1 |
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