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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Endoge nous cellutases in animals: isolation of β-1, 4-endoglucanase genes from two species of plant parasitic cyst nemtodes显示文摘 | GEERT S JACK P W G STOKKERMAN S | 1998 | Proc Natl Acad Sci USA1998，95，9： | 1 |
| 3 | Prevention of venous thromboembolism:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)显示文摘 | Geerts W H Bergqvist D Pineo G F | | 0，，6： | 1 |
| 4 | Prevention of venous thromboembolism:The seventh ACCPconference on antithrombotic and thronbolytic therapy显示文摘 | Geerts W Pineo G Heir J | 2004 | Chest2004，126，： | 1 |
| 5 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations:role of iron,nickel and cobalt显示文摘 | ZANDVOORT M H GEERTS R LETTINGA G | 2003 | Enzyme Microbial Technol2003，33，23： | 1 |
| 6 | Prevention of v m: American college of chest physicians evidence based clinical practice guidelines (8th edition) 显示文摘 | Geerts W H Bergqvist D Pinco G F | 2008 | Chest2008，133，： | 1 |
| 7 | Prevention of venous thromboembolism: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines(8th Edition)显示文摘 | GEERTS W H BERGQVIST D PINEO G F | 2008 | Chest2008，133，6： | 1 |
| 8 | Prevention of venous thromboembolism显示文摘 | CLAGETT G P ANDERSON F A Jr GEERTS W | 1998 | Chest1998，114，： | 1 |
| 9 | Methanoldegradation in granular sludge reactors at sub-optimal metalconcentrations:role of iron,nickel and cobalt显示文摘 | ZANDVOORT M H GEERTS R LETTINGA G | 2003 | Enzyme andMicrobial Technology2003，33，23： | 1 |
| 10 | Discriminating between critical and nncritical disturbances in (Bio) chemical bach processes prediction Research, NAES T, using m 显示文摘 | GEERT G JEF V JAN F | 2012 | ulti-model fault detection and end-quality Industrial and Engineering Chemistry2012，51，1： | 1 |
| 11 | Practial management of venous thromboembolism following pelvic fractures显示文摘 | Montgomery K D Geerts W H Potter H G | 1997 | Orthop Clin North Am1997，28，3： | 1 |
| 12 | Prevention of thromboembolism 显示文摘 | Clagett G Andersen F Geerts W | 1998 | Chest1998，114，： | 1 |
| 13 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations:role of iron,nickel and cobalt显示文摘 | Zandvoort M H Geerts R Lettinga G | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 14 | Prevention of venous thromboembolism:a review显示文摘 | Geerts W H Heit J A Clagett G P | 2001 | Chest2001，，： | 1 |
| 15 | Prevention of Venous Thromboembolism显示文摘 | Geerts W H Heir J A Clagett G P | 2001 | Chest2001，119，1： | 1 |
| 16 | Is Z-disk degradation responsible for postmortem tenderization显示文摘 | Richard G Taylor H Geert G | 1995 | J Anim Sci1995，73，： | 1 |
| 17 | Prevention of venous thromboembolism: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines(8th Edition)显示文摘 | GEERTS W H BERGQVIST D PINEO G F | 2008 | Chest2008，133，6： | 1 |
| 18 | Linking ultrastructure and function in four genera of anaerobic ammonium-oxidizing bacteria: Cell plan, glycogen storage, and localization of cytochrome c proteins显示文摘 | van Niftrik L Geerts W J C van Donselaar E G | 2008 | Journal of Bacteriology2008，190，2： | 1 |
| 19 | 'Prevention of Ve- nous Thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy显示文摘 | Geerts W I-I -Pineo G F Heit J A | 2004 | Chest2004，126，3： | 1 |
| 20 | Molecular mechanism of anaerobic ammonium oxidation 显示文摘 | Kartal B Maalcke W J Almeida N M Cirpus I Gloerich J Wim Geerts Camp H J M O Harhangi H R Janssen-Megens E M Francoijs K-J Stunnenberg H G Keltjens J T Jetten M S M Strous M | 2011 | Nature2011，479，： | 1 |
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