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| 1 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 2 | EGFR targeting therapies:monoclonal antibodies versus tyrosine kinase inhibitors similarities and differences显示文摘 | Dassonville O Bozec A Fischel J L | 2007 | Crit Rev Oncol Hematol2007，62，1： | 1 |
| 3 | Cyclometallated platinum (II) complexes containing pyridyl-acetylide ligands: the selective influence of lead binding on luminescence显示文摘 | Lanoe P H Bozec H L Williams J A G | 2010 | Dalton Trans2010，39，： | 1 |
| 4 | Activation of caspases-3, -6, and -9 during finasteride treatment of benign prostatic hyperplasia显示文摘 | Bozec A Ruffion A Decaussin M | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 5 | Epidermal growth factor receptor/ angiogenesis dual targeting: preclinical experience 显示文摘 | Bozec A Fischel J Milano G | 2006 | Curr Opin Oncol2006，18，： | 1 |
| 6 | Hypersonic model testing in a shock tunnel 显示文摘 | Olivier H Gronig H Bozec A L | 1995 | AIAA Journal1995，33，2： | 1 |
| 7 | Fosl2 promotes leptin gene expression in human and mouse adipocytes显示文摘 | Wrann C D Eguchi J Bozec A | 2012 | J Clin In- vest2012，122，3： | 1 |
| 8 | Clinical impact of cer-vical lymph node involvement and central neck dissection in pa-tients with papillary thyroid carcinoma: a retrospective analysis of368 cases显示文摘 | Bozec A Dassonville O Chamorey E | 2011 | Eur Arch Otorhinolaryngol2011，268，8： | 1 |
| 9 | Assessment of carotid stiffness and intima-media thickness from ultrasound data, comparison between two methods 显示文摘 | Bianchini E Bozec E Gemignani V | 2010 | J Ultrasound Med2010，29，： | 1 |
| 10 | Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model 显示文摘 | BOZEC A SUDAKA A FISCHEL J L | 2008 | Br J Cancer2008，99，1： | 1 |
| 11 | Large shareholder entrench- ment and performance:Empirical evidence from Canada 显示文摘 | Bozec Y Laurin C | 2008 | Journal of Business Finance & Ac- counting2008，35，12： | 1 |
| 12 | Influence of stain- less steel surface treatment on the oxygen reduction reaction in seawater显示文摘 | Le Bozec N Compare C L'her M | 2001 | Corros Sci2001，43，： | 1 |
| 13 | R&D activity in Cana- da: Does corporate ownership structure matter? 显示文摘 | Jackie D V Laurin C Bozec Y | 2010 | Canadian Journal of Administrative Studies2010，27，2： | 1 |
| 14 | Large shareholder entrenchment and performance: Empirical evidence from Canada 显示文摘 | Bozec Y Laurin C | 2008 | Journal of Business Finance and Accounting2008，35，12： | 1 |
| 15 | Combined effects of bevacizumab with erlotinib and irradiation:a preclini- cal study on a head and neck cancer orthotopic model 显示文摘 | Bozec A Sudak A Fischel JL | 2008 | Br J Cancer2008，99，1： | 1 |
| 16 | Large shareholder entrenchment and performance: Empirical evidence from Canada 显示文摘 | Bozec Y Laurin C | 2008 | Journal of Business Finance & Accounting2008，35，1： | 1 |
| 17 | FOSL2 promotes leptin gene expression in human and mouse adipocytes显示文摘 | Wrann Christiane D Eguchi Jun Bozec Aline Xu Zhao Mikkelsen Tarjei Gimble Jeffrey Nave Heike Wagner Erwin F Ong Shao-En Rosen Evan D | 2012 | EN2012，，3： | 1 |
| 18 | Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease 显示文摘 | Briet M Bozec E Laurent S | 2006 | Kidney Int2006，69，： | 1 |
| 19 | Activation of Caspase-3,-6, and-9 cluring finasteride tveatment of benign prostatic hyperplasia显示文摘 | Bozec A Ruffion A | 2005 | J Clin Endocrinol Metal2005，90，1： | 1 |
| 20 | The influence of microstructure on the corrosion behavior of AZ91D studies by scanning Kelvin probe force microscopy and scanning Kelvin probe 显示文摘 | JONSSON M THIERRY D BOZEC N L | 2006 | Corrosion Science2006，48，： | 1 |
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