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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | Sarcopenia in heart failure: mechanisms and therapeutic strategies显示文摘长期的心失败(CHF ) 是一个高度流行的条件在之中老并且与可观的病态, institutionalization 和死亡被联系。在它的先进阶段, CHF 被肌肉质量和力量的损失经常伴随。Sarcopenia 是活跃地与大量不利健康结果由于它的协会在最近的年里被学习了的衰老老人症候群。这评论的目标是讨论在 CHF 和 sarcopenia 之间的关系,与分享的 pathophysiological 小径和处理的一个焦点。营养不良,全身的发炎,内分泌的不平衡,和氧化应力看起来连接 sarcopenia 和 CHF。在肌肉发达的水平, ubiquitin proteasome 系统,发信号的 myostatin,和 apoptosis 的改变在 sarcopenia 和 CHF 被描述了并且能在肌肉质量和功能的损失起一个作用。阻碍肌肉在 CHF 病人浪费的前进的可能的治疗学的策略包括变换血管收缩素的酶禁止者和 β 的蛋白质和维生素 D 补充,结构化的物理锻练,和管理; -blockers。有生长荷尔蒙,睾丸激素,和 ghrelin 的神经质的补充也作为潜在的治疗被讨论。 | Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'Angelo Alex N Sisto Francesco Landi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 25 |
| 3 | African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era. | Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 4 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection显示文摘 | Maria Fort Marina Sibila Miquel Nofrarías Eva Pérez-Martín Alex Olvera Enric Mateu Joaquim Segalés | 2010 | Veterinary Immunology and Immunopathology2010，，3： | 2 |
| 6 | Single crystal growth of SiGe by the Czochralski technique显示文摘 | ABROSIMOV N V ROSSOLENKO S N ALEX V | 1996 | J Crystal Growth1996，，166： | 1 |
| 7 | Idiopathic inflammatory myopathies,signified by distinctive peripheral cytokines,chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand显示文摘 | Szodoray E Alex P Knowlton N | | 0，，： | 1 |
| 8 | A Systematic Review of Randomized, Double-Blind, Placebo-Controlled Trials Examining the Clinical Efficacy of Vitamin D in Multiple Sclerosis显示文摘 | Pozuelo-moyano Beatriz Benito-le?n Juli?n Mitchell Alex J Hern?ndez-gallego Jes?s | 2013 | Neuroepidemiology2013，，3： | 1 |
| 9 | U- sing magnetic levitation for non-destructive quality control of plastic parts 显示文摘 | HENNEK J W ALEX N BALA S A etal | 2015 | Advanced Materials2015，27，9： | 1 |
| 10 | Sentinel lymph node radiolocalization in head and neck squamous carcinoma显示文摘 | ALEX J C SASAKI C T KRAG D N | 2000 | Larygoscope2000，110，： | 1 |
| 11 | An Evaluation of Divergent Perspectives on Customer Relationship Management: Towards a Common Understanding of an Emerging Phenomenon显示文摘 | Danny N Bellenger Wesley J Johnston | 2004 | Industrial Marketing Management2004，33，： | 1 |
| 12 | Star pattern identification using discrete attitude variation technique显示文摘 | Rao G N Bhat M S Alex T K | 2005 | Journal of Guidance Control and Dynamics2005，28，6： | 1 |
| 13 | Adaptive heamforming algorithms with robustness against jammer motion 显示文摘 | Alex B Ulrich N Johann F B | 1997 | IEEE Transactions on Signal Processing1997，45，7： | 1 |
| 14 | Environmental Fate of Mineral, Vegetable and Trans - esterified Vegetable Oils 显示文摘 | Alex Cornish N S Battersby | 2006 | Pesticide Science2006，37，2： | 1 |
| 15 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 16 | Virtual auditing agents: the EDGAR agent challenge 显示文摘 | Kay M N Alex K Rajendra P S Vasarhelyi Miklos A | 2000 | Decision Support System2000，28，： | 1 |
| 17 | Experimental test of the importance of preen oil in rock doves 显示文摘 | Brett R Moyer Alex N Rock Dale H Clayton | 2003 | The Auk2003，120，2： | 1 |
| 18 | Computational analysis of stall and separation control in centrifugal compressors显示文摘 | Alex Stein S N L S | 2000 | Journal of Propulsion and Power2000，16，1： | 1 |
| 19 | In situ identification of polyphosphate and poly hydroxyalkenoate accumulating traits for microbial populations in a biological phosphorus removal process 显示文摘 | Wen T L Alex T N | 2001 | Environmental Microbiology2001，3，5： | 1 |
| 20 | Analysis of aprepitant for prevention of chemotherapy - in- duced nausea and vomiting with moderately and highly emeto- genic chemotherapy 显示文摘 | Alex Molassiotis Allison Martin Nguyen Cynthia N | 2013 | Future oncology ( London Eng- land)2013，9，10： | 1 |
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