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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | A Methodological Framework for the Study of Residential Location and Travel-to-work Mode Choice under Central and Suburban Employment Destination patterns 显示文摘 | Amaya V Aisling R F | 2009 | Transportation Research Part A2009，43，： | 1 |
| 3 | Oestrogen and the colon:potential mechanisms for cancer prevention显示文摘 | Rory K Dara O Aisling M | 2008 | Lancet Oncol2008，9，4： | 1 |
| 4 | Oestrogen and the colon: potential mechanisms for cancer prevention显示文摘 | Rory Kennelly Dara O Kavanagh Aisling M Hogan Desmond C Winter | 2008 | Lancet Oncology2008，，4： | 1 |
| 5 | Mc Mahon et al;Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1显示文摘 | Christiana Leimena Aisling C | 2004 | Biochem Biophys Res Commun2004，，： | 1 |
| 6 | Sol-gel based optical carbon dioxide sensor employing dual luminophore referencing for application in food packaging technology显示文摘 | Christoph von Bultzingslowen Aisling K McEvoy Colette McDoagh | | 0，，11： | 1 |
| 7 | Measuring Outcomes in People Who Have Had a Stroke and Their Carers: Can the Telephone Be Used?显示文摘 | Tammy Hoffmann Linda Worrall Sally Eames Aisling Ryan | 2010 | Topics in Stroke Rehabilitation2010，，2： | 1 |
| 8 | Oestrogen and the colon: potential mechanisms for cancer prevention显示文摘 | Rory Kennelly Dara O Kavanagh Aisling M Hogan Desmond C Winter | 2008 | Lancet Oncology2008，，4： | 1 |
| 9 | Wetland for rehabilitation of metal mine wastes显示文摘 | AISLING D SULLIVAN O OLIVE M | 1999 | Biology and Environment1999，99，1： | 1 |
| 10 | Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP, DPPH, ABTS and Folin-Ciocaheu methods显示文摘 | Peter C Wootton B Aisling M | 2011 | Food Research I nternational2011，44，1： | 1 |
| 11 | Estrogen and its role in gastrointestinal health and disease显示文摘 | Aisling M. Hogan Danielle Collins Alan W. Baird Des C. Winter | 2009 | International Journal of Colorectal Disease2009，，12： | 1 |
| 12 | Risk of hepatotoxicity associated with fluoroquinolones: A national case–control safety study显示文摘 | THAMIR M. ALSHAMMARI E. PAUL LARRAT HALEY J. MORRILL AISLING R. CAFFREY BRIAN J. QUILLIAM KERRY L. LAPLANTE | 2014 | American Journal of Health-System Pharmacy2014，，1： | 1 |
| 13 | An examination of what metaphor construction reveals about the evolution of preservice teachers’ beliefs about teaching and learning显示文摘 | Aisling M. Leavy Fiona A. McSorley Lisa A. Boté | 2006 | Teaching and Teacher Education2006，，7： | 1 |
| 14 | L-type calcium current of isolated rat cardiac myocytes in experimental uraemia 显示文摘 | Paul D Aisling C McMahon | 2000 | Nephrol Dial Transplant2000，15，6： | 1 |
| 15 | Life Cycle As- sessment Modelling of Stormwater Treatment Systems显示文摘 | Aisling D O'Sullivan Daniel Wieke Tyler J Hengen | 2015 | Journal of Environ- mental Management2015，，149： | 1 |
| 16 | Adaptor usage and Toll-like receptor signaling specifictry显示文摘 | Aisling D Luke A | 2005 | FEBS letters2005，579，33： | 1 |
| 17 | Heart disease in pregnancy 显示文摘 | Aisling JC Sara AT | 2006 | Medicine2006，34，8： | 1 |
| 18 | Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP, DPPH, ABTS and Folin–Ciocalteu methods显示文摘 | Peter C. Wootton-Beard Aisling Moran Lisa Ryan | 2010 | Food Research International2010，，1： | 1 |
| 19 | Heart disease in pregnancy显示文摘 | Aisling JC Sara AT | 2006 | Medicine2006，34，8： | 1 |
| 20 | Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma显示文摘BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials ongoing.In locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.AIM To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.METHODS In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials ongoing.Although surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative setting.The aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell viability.This study was a hybrid combination of in vitro and ex vivo models.Quantification of serum immune proteins was performed by enzyme-linked immunosorbent assay.Flow cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC biopsies.Cell viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 assay.RESULTS We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in OAC.There were two distinct subcohorts with one demonstrating significant upregulation of ICs and the contrary in the other cohort.Increasing IC expression post RT was associated with a more aggressive tumour phenotype and adverse features of tumour biology.The use of anti-PD-1 and anti-PD-L1 immunotherapies in combination with radiation resulted in a significant and synergistic reduction in viability of both radiosensitive and radioresistant OAC cells in vitro.Interleukin-21(IL-21)and IL-31 significantly increased,with a concomitant reduction in IL-23 as a consequence of 4 Gray radiation.Similarly,radiation induced an anti-angiogenic tumour milieu with reduced expression of vascular endothelial growth factor-A,basic fibroblast growth factor,Flt-1 and placental growth factor.CONCLUSION The findings of the current study demonstrate synergistic potential for the use of ICIs and ionising radiation to potentiate established anti-tumour responses in the neoadjuvant setting and is of particular interest in those with advanced disease,adverse features of tumour biology and poor treatment responses to conventional therapies. | Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght | 2022 | World Journal of Gastroenterology2022，28，21： | 1 |
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