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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | mTOR Signaling in Growth Control and Disease显示文摘 | Mathieu Laplante David M. Sabatini | 2012 | Cell2012，，2： | 7 |
| 3 | 利奈唑胺和万古霉素治疗甲氧西林耐药金黄色葡萄球菌感染的疗效比较显示文摘甲氧西林耐药金葡菌(MRSA)感染可选择的治疗药物有限,多年来万古霉素是治疗的金标准。对万古霉素敏感性下降菌株的出现,增加了对新型抗感染药物的需求,噁唑烷酮类药物利奈唑胺是治疗MRSA感染的新药。然而,评价该药临床疗效的研究较少。 | Caffrey AR Quilliam BJ Laplante KL 秦晓华(摘译) 王明贵(审校) | 2011 | 中国感染与化疗杂志2011，11，4： | 2 |
| 4 | DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival显示文摘 | Timothy R. Peterson Mathieu Laplante Carson C. Thoreen Yasemin Sancak Seong A. Kang W. Michael Kuehl Nathanael S. Gray David M. Sabatini | 2009 | Cell2009，，5： | 2 |
| 5 | DERTOR is an roTOR inhibitor frequently overexpressed in multiple myeloma cells and re- quired for their survival显示文摘 | Peterson TR Laplante M Thoreen CC | 2009 | Cell2009，137，5： | 1 |
| 6 | mTOR signaling in growth control and dis- ease显示文摘 | Laplante M Sabatini D M | 2012 | Cell2012，149，2： | 1 |
| 7 | DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival显示文摘 | Peterson TR Laplante M Thoreen CC | 2009 | Cell2009，137，5： | 1 |
| 8 | In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model 显示文摘 | LaPlante KL Mermel LA | 2007 | Nephrol Dial Transplant2007，22，8： | 1 |
| 9 | Mechanisms of wound reepithelialization:hints from a tissue-engineered reconstructed skin to long-standing questions显示文摘 | Germain L Auger FA | 2001 | FASEB J2001，15，13： | 1 |
| 10 | Confronting the Environmental Kuznets Curve显示文摘 | Dasgupta S Laplante B Wang H | 2002 | The Journal of Economic Perspectives2002，16，1： | 1 |
| 11 | Confronting the Environment Kuznets Curve显示文摘 | Dasgupta S Laplante B Wang H | 2002 | Journal of Economic Perspectives2002，16，1： | 1 |
| 12 | Obesity-associated improvements in metabolic profile through expansion of adipose tissue显示文摘 | Kim J Y van de Wall E Laplante M | 2007 | J Clin Invest2007，117，9： | 1 |
| 13 | DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival显示文摘 | Peterson Laplante Thoreen | 2009 | Cell2009，137，5： | 1 |
| 14 | DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival显示文摘 | Peterson T R Laplante M Thoreen C C | 2009 | Cell2009，137，5： | 1 |
| 15 | mTOR signaling in growth control and disease显示文摘 | Laplante and Sabatini | 2012 | Cell2012，149，2： | 1 |
| 16 | mTOR signaling in growth control and disease显示文摘 | Laplante M Sabatini DM | 2012 | Cell2012，149，： | 1 |
| 17 | A rough set-based approach to handling spatial uncertainty in binary images 显示文摘 | SINHA D LAPLANTE P | 2004 | Engineering Applications of Artificial Intelligence2004，17，1： | 1 |
| 18 | The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations显示文摘 | Avramoglu R K Laplante M A Quang K L | 2013 | Canadian Journal of Diabetes2013，37，5： | 1 |
| 19 | mTORC1 controls fasting-induced ketogenesis and its modulation by ageing显示文摘 | Sengupta Peterson Laplante | 2010 | Nature2010，468，7327： | 1 |
| 20 | Prevalence of risk factors for dysglyeemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting显示文摘 | LaPlante K L Mersfelder T L Ward K E | 2008 | Pharmaeotherapy2008，28，1： | 1 |
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