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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | 哪些凝血标志物可以增加传统危险因素对冠心病和缺血性中风的预测价值?Caerphilly研究显示文摘背景:目前鲜有研究证实,凝血标志物是否可以独立于传统危险因素与患冠心病和缺血性中风相关。本研究对11个反映凝血过程不同方面的标志物进行研究,以期发现在排除传统危险因素的作用之后,它们是否仍有预测价值。
方法与结果:在1984~1988年间,共2398名49~65岁男子接受检查,他们中大部分人采取了空腹血测定血脂和凝血标志物。对他们进行了平均13年的随访,记录了心血管事件(cardiovascular disease,CVD)发生情况。共发生486起心血管事件,353起新发生冠心病,133起新发生缺血性中风。经单变量分析,发现纤维蛋白原、低活化蛋白C值、D-二聚体、组织性纤溶酶原(tPA)、纤溶酶原激活物抑制物-1(PAI-1)都显著与CVD相关。将传统危险因素引入比例风险模型后,采用多变量分析方法,发现纤维蛋白原、D-二聚体、纤溶酶原激活物抑制物-1都显著与CVD相关,并且因子VIIc呈负相关(P=0.001)。在纳入传统危险因素的模型中,预先不存在CVD者,若具有预期风险构成最高3种的危险因素,则其发生CVD的风险是具有最低3位者的2.7倍。当模型包括4个凝血相关因素时,此值升至3.7倍。
结论:除传统的危险因素外,纤维蛋白原、D-二聚体、纤溶酶原激活物抑制物-1活性、因子VIIc均有预测中年男性的冠心病\缺血性中风发生的作用。 | Smith A 秦春常 | 2005 | 中国分子心脏病学杂志2005，5，6： | 43 |
| 3 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 4 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 5 | 标准·方案·指南——2014年美国癌症学会最新宫颈癌筛查指南及筛查中存在的问题显示文摘美国癌症学会(ACS)每年都会发布有关癌症早期检测、癌症筛查率数据与趋势报告及相关问题的指南,并会持续关注可能需要在癌症筛查指南中做出相应改变与更新的医学科学文献中出现的新证据以及需要传达给临床工作者与公众的筛查相关信息。在制定新指南的过程中,ACS至少每5年对指南更新1次,如有重要新证据出现,则更新间隔时间会更短。本期就2014年ACS关于宫颈癌筛查的最新指南报道如下。 | Robert A Smith Deana Manassaram-Baptiste Durado Brooks Vilma Cokkinides Mary Doroshenk Debbie Saslow Richard C Wender Otis W Brawley 王静 | 2014 | 中国全科医学2014，17，27： | 16 |
| 6 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 7 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 8 | 绝缘门极双极晶体管的弧焊逆变器显示文摘介绍了采用绝缘门极双极晶体管(IGBT)作为开关元件的弧焊逆变器.论述了其工作原理,IGBT的特点,以及使用莱姆电流传感器实现的电流反馈系统.并通过效率、功率因数的测定及工艺试验表明,所研制的IGBT弧焊逆变器是一种节能、轻便、很有发展前途的逆变电源. | 王志强 黄石生 伍月华 G A Smith | 1992 | 焊接学报1992，13，1： | 7 |
| 9 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 10 | Acute chylous ascites mimicking acute appendicitis in a patient with pancreatitis显示文摘We report a case of acute chylous peritonitis mimicking acute appendicitis in a man with acute on chronic pancreatitis. Pancreatitis, both acute and chronic, causing the development of acute chylous ascites and peritonitis has rarely been reported in the English literature. This is the fourth published case of acute chylous ascites mimicking acute appendicitis in the literature. | Emily K Smith Edmund Ek Daniel Croagh Lavinia A Spain Stephen Farrell | 2009 | World Journal of Gastroenterology2009，15，38： | 7 |
| 11 | TGF-β1壳聚糖微球的制备及其缓释效果研究显示文摘目的:制备转化生长因子β1(TGF-β1)壳聚糖微球,并研究其体外缓释效果。方法:采用乳化交联的方法制备壳聚糖微球,然后吸附TGF-β1获得TGF-β1壳聚糖微球。利用酶联免疫吸附的方法(ELISA)动态检测7 d内TGF-β1壳聚糖微球的缓释效果,并绘制释放曲线。结果:壳聚糖微球形态较好,粒径为(8.6±2.8)μm。TGF-β1壳聚糖微球在缓释实验的前12 h内释放速度较快,随后释放趋于平稳。7 d内微球的TGF-β1释放率为42.6%。结论:TGF-β1壳聚糖微球的制备工艺简单可行,成球性好,具有良好的缓释效果。 | 李芳 赵守亮 吴红 亢彦强 苏丽萍 Smith A J | 2005 | 牙体牙髓牙周病学杂志2005，15，12： | 6 |
| 12 | 健康儿童接种流感疫苗效能与效果的系统评价摘要显示文摘 | Jefferson T Smith S Demicheli V Harnden A Rivetti A Di Pitetrantonj C 刘佑韧 | 2005 | 中国循证医学杂志2005，5，5： | 6 |
| 13 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 14 | 妊娠期肝内胆汁淤积症女性使用熊去氧胆酸治疗与安慰剂比较:一项随机对照试验显示文摘【据《Lancet》2019 年9 月报道】题:妊娠期肝内胆汁淤积症女性使用熊去氧胆酸治疗与安慰剂比较:一项随机对照试验(作者Chappell LC 等)妊娠期肝内胆汁淤积症的特征是产妇瘙痒和血清胆汁酸浓度升高,与死产、早产和新生儿入院率增加有关。熊去氧胆酸是被广泛应用的治疗方法,但是没有充分的证据基础。 | 刘宇维 牛俊奇 CHAPPELL LC BELL JL SMITH A | 2020 | 临床肝胆病杂志2020，36，2： | 6 |
| 15 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 16 | Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship显示文摘 | Hyun-pil Lee Xiongwei Zhu Gang Liu Shu G Chen George Perry Mark A Smith Hyoung-gon Lee | 2010 | Cell Research2010，20，4： | 5 |
| 17 | Liver transplantation for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignancy of the liver. It usually occurs in the setting of chronic liver disease and has a poor prognosis if untreated. Orthotopic liver transplantation (OLT) is a suitable therapeutic option for early,unresectable HCC particularly in the setting of chronic liver disease. Following on from disappointing initial results,the seminal study by Mazzaferro et al in 1996 established OLT as a viable treatment for HCC. In this study,the 'Milan criteria' were applied achieving a 4-year survival rate similar to OLT for benign disease. Since then various groups have attempted to expand these criteria whilst maintaining long term survival rates. The technique of living donor liver transplantation has evolved over the past decade,particularly in Asia,and published outcome data is comparable to that of OLT. This article will review the evidence,indications,and the future direction of liver transplantation for liver cancer. | Sudeep Tanwar Shahid A Khan Vijay Paul Bob Grover Catherine Gwilt Belinda Smith Ashley Brown | 2009 | World Journal of Gastroenterology2009，15，44： | 4 |
| 18 | HIGH-ENERGY IONS PRODUCED IN EXPLOSIONS OF SUPERHEATED ATOMIC CLUSTERS显示文摘 | T Ditmire J W G Tisch E Springate M B Mason N Hay R A Smith J Marangos and M H R Hutchinson | | 0，，： | 4 |
| 19 | Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure:the MIRACLE ICD Trial显示文摘 | Young JB Abraham WT Smith A | | Journal of the American Medical Association0，，： | 3 |
| 20 | Nutritional therapy for active Crohn’s disease显示文摘Nutritional therapy for active Crohn’s disease (CD) is an underutilised form of treatment in adult patients, though its use is common in the paediatric population. There is evidence that nutritional therapy can effectively induce remission of CD in adult patients. Enteral nutrition therapy is safe and generally well tolerated. Meta-analysis data suggest that corticosteroids are superior to nutritional treatment for induction of remission in active CD. However, the potential side effects of such pharmacotherapy must be taken into consideration. This review examines the evidence for the efficacy of elemental and polymeric diets, and the use of total parenteral nutrition in active CD. | Paul A Smith | 2008 | World Journal of Gastroenterology2008，14，27： | 3 |
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