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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 3 | Anphylax is due to red imported fire antsting 显示文摘 | Solley GO Vanderwoude C Knight GK | 2002 | Med J Austral2002，176，： | 1 |
| 4 | Nutri?ent-gene interaction: metabolic genotype-phenotype re?lationship显示文摘 | GO V L NGUYEN C T HARRIS D M | 2005 | TheJournal of Nutrition2005，135，12： | 1 |
| 5 | Structure and thermal properties of blends of nylon 6 and a liquid crystal copolyester显示文摘 | Campoy I Go'mez M A Marco C | | 0，，25： | 1 |
| 6 | Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants显示文摘 | Fang M C Go A S Chang Y | 2012 | Stroke2012，43，7： | 1 |
| 7 | Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines显示文摘 | Morais C Pat B Go be G | 2006 | Nephrol Dial Transplant2006，21，： | 1 |
| 8 | Optimal Pricing and Ordering Policy under Permissible Delay in Payments 显示文摘 | TEN GJ T GHAN G C T GO YAL S K | 2005 | International Journal of Product on Economics2005，97，12： | 1 |
| 9 | Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer显示文摘 | WITTON C J REEVES J R GOING J J | | 0，，03： | 1 |
| 10 | Clinical, EEG, MRI, MEG, and surgical outcomes of pediatric epilepsy with astrocytic inclu- sions versus focal cortical dysplasia 显示文摘 | Alshafai L Ochi A Go C | 2014 | Epilepsia2014，55，10： | 1 |
| 11 | Jeavons syndrome existing as occipital cortex initiating generalized epilepsy 显示文摘 | Viravan S Go C Ochi A | 2011 | Epilep-sia2011，52，7： | 1 |
| 12 | Bilateral Diffusion tensor abnomalities of temporallobe and cingulate gyrus white mat-ter in children with temporal lobe epilepsy显示文摘 | Nilsson D Go C Rutka JT | 2008 | Epilepsy Res2008，81，23： | 1 |
| 13 | Effect of laser shock processing on fatigue crack growth and fracture toughness of 6061-T6 aluminum alloy显示文摘 | Rubio-Gonzalez C Ocan'a J L Go mez-Rosas G | | 0，，1： | 1 |
| 14 | Automatic change detection of build-ings in urban environment from very high spatial resolution images using existing geodatabase and prior knowledge显示文摘 | Bouziani M Go'ta K He D C | 2010 | ISPRS Journal of PhotogTammetry and Remote Sensing2010，65，1： | 1 |
| 15 | Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction显示文摘 | Chiu K C Chu A Go V I J | 2004 | Am J Clin Nu tr2004，79，5： | 1 |
| 16 | Interaction of IgA with Fca receptors of human mesangial cells activates transcription factor nuclear factor-kB and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10 显示文摘 | Duque N Go' mez-Guerro C Egido J | 1997 | J Immunol1997，159，7： | 1 |
| 17 | Morin, a flavonoid frommoraceae, induces apoptosis by induction of BAD proteinin human leukemic ceUs显示文摘 | Park C Lee WS Go SI | 2014 | Int J Mol Sci2014，16，1： | 1 |
| 18 | Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine显示文摘 | Osoata GO Hanazawa T Brindicci C | 2009 | Chest2009，135，6： | 1 |
| 19 | Maintenance strategy based on a multicriterion classification of equipments 显示文摘 | E'LIX C Go'mez de Leo'n Hijes JOSE Javier Ruiz Cartagena | 2006 | Reliability Engineering and System Safety2006，91，： | 1 |
| 20 | Fudosteine Condensateof COPD and Its Inhibition by Peroxynitrite Elevation in ExhaledBreath显示文摘 | Osoata GO Hanazawa T Brindicci C | 2009 | Chest2009，135，6： | 1 |
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