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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 3 | Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | | 0，，11： | 3 |
| 4 | Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial 1显示文摘 | H.H Hartgrink C.J.H van de Velde H Putter I Songun M.E.T Tesselaar E.Klein Kranenbarg J.E de Vries J.A Wils J van der Bijl J.H.J.M van Krieken | 2004 | European Journal of Surgical Oncology2004，，6： | 2 |
| 5 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 6 | Extended lymph node dissection for gastric cancer:who may benefit? Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clini On- col2004，22，11： | 1 |
| 7 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘 | van der HAGE J A van de VELDE C J H JULIEN J P | 2001 | J Clin Oneol2001，19，22： | 1 |
| 8 | In-vitro matured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DeVos A Van de Velde H Joris H | 1999 | Hum Reprod1999，14，7： | 1 |
| 9 | Sertoli cell-condi- tioned medium induces germ cell differentiation in human embryon- ic stem cells 显示文摘 | Geens M Sermon KD Van de Velde H et at | 2011 | J Assist Reprod Genet2011，28，5： | 1 |
| 10 | The mechanism behind microstmeture formation in mixed whey protein-polysaccharide cold- set gels 显示文摘 | de Jong S Klok H J van de Velde F | 2009 | Food Hydroeolloids2009，23，： | 1 |
| 11 | Micrometastasis and survival in stage Ⅱ colorectal cancer显示文摘 | Leifers G J Cleton Jansen A M Van de Velde C J H | 1998 | N Engl J Med1998，339，4： | 1 |
| 12 | The effects of extreme water level fluctuations on the wetland vegetation of a nymphaeid-dominated oxbow lake in The Netberlands显示文摘 | BROCK T C M VELDE VAN DER G STEEG VAN DE H M | 1987 | Arch Hydrobiologia1987，，27： | 1 |
| 13 | Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer显示文摘 | van de VELDE H KARASEK P | 2004 | J Clin Oncol2004，22，8： | 1 |
| 14 | Phase Ⅲ trial of gemeitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer显示文摘 | Van Cutsem E van de Velds H Karasek P | 2004 | J Clin Oncol2004，22，： | 1 |
| 15 | Pharse Ⅲtrial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer 显示文摘 | Van de velde P Karasek H | 2004 | J Clin Oncol2004，，： | 1 |
| 16 | Necrotizingenterocolitis : A clinical review on diagnostic biomarkers and the roleof the intestinal microbiota显示文摘 | Niemarkt H J de Meij T G van de Velde M E w al | 2015 | Inflamm Bowel Dis2015，21，43： | 1 |
| 17 | Influence of inviv- idual sperm morphology on fertilization, embry morphology, and pregnancy outcome of intracytoplasmic sperm injection 显示文摘 | Devos A Van De Velde H Jeris H | 2003 | Fertil Steil2003，79，1： | 1 |
| 18 | The importanee of HLA-G expression in embryos, trophoblast cells, and ernbryonie stem cells 显示文摘 | RIZZO R VERCAMMEN M van de VELDE H | 2011 | Cell Mol Life Sei2011，68，3： | 1 |
| 19 | The mechanism behind microstructure formation in mixed whey protein-polysaccharide cold-set gels显示文摘 | de Jong S Klok H J van de Velde F | 2009 | Food Hydrocolloids2009，23，3： | 1 |
| 20 | In-vitro ,natured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DE VOS A VAN DE VELDE H JORIS H | 1999 | Hum Reprod1999，14，： | 1 |
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