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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | 整合患者导向的测量工具项目编制等距量表实现ICF类目用于评定的可操作化显示文摘目的通过整合不同的患者导向的测量工具的项目来编制ICF特定类目的等距量表结构。方法使用有效的122例类风湿关节炎患者的样本资料进行心理测量研究。患者完成6个不同的以患者导向的测量工具。将这些测量工具项目的内容与ICF类目进行匹配。对项目反应等级进行Rasch分析用于检查这些测量工具项目是否说明了ICF类目b130:能量和驱力功能,从而构成一个心理测量可靠的等距量表。结果 19个项目与b130能量和驱力功能有关。根据2χ检验和Z值统计,19个项目中的16个项目拟合Rasch模型(项目和个人的ZMean=0.451,ZSD=1.085和ZMean=-0.223,ZSD=1.132)。Person分离指数rβ是0.93。结论可以构建ICF类目等距量表使得单个ICF类目可操作化。每个项目的原始格式在等距量表中保持不变。本研究在ICF的操作和将来的实施方面迈出了重要的一步。 | Cieza A Hilfiker R Boonen A Chatterji N Kostanjsek N stün BT Stucki G 叶祥明 朱根应 田亮 邱卓英 | 2011 | 中国康复理论与实践2011，17，2： | 7 |
| 4 | Cellular trafficking of nicotinic acetylcholine receptors显示文摘烟碱的醋胆素受体(nAChRs ) 在整个身体起关键作用。细胞的地点的精确规定和神经原和目标房间上的 nAChRs 的可获得性对他们的合适的功能批评。动态, nAChRs 的 translational 以后规定,特别地在房间的不同分隔空间之中他们的运动控制,是那条规定的一个重要方面。新信息和新技术的联合把 nAChR trafficking 的学习为新突破平衡。 | Paul A ST JOHN | 2009 | Acta Pharmacologica Sinica2009，30，6： | 3 |
| 5 | 安捷伦液相/离子阱(XCT)质谱检测虾仁及家禽中的硝基呋喃代谢物显示文摘在液相/离子阱质谱上,利用液相/质谱/质谱方法对鸡肉及虾仁中硝基呋喃代谢物残留进行了定性定量分析.对于四种硝基呋喃代谢物,其定量限在0125到05μg·kg-1的范围内,分析结果完全满足欧盟的1μg·kg-1的最低检测限量的要求. | Bernhard wüst Christian Sauber Hans (J) A van Rhijn | 2004 | 环境化学2004，23，6： | 2 |
| 6 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 7 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 8 | Biphasic relaxation of the opossum lower esophageal sphincter: roles of NO,VIP and CGRP 显示文摘 | Oh ST Murray JA | 1999 | Am J Physiol1999，277，31： | 1 |
| 9 | Pharma cokinetics of enrofloxacin in fingerling rainbow trout Concorhynchus mykiss显示文摘 | WOOSTER G A ST LEGERJ | 1992 | J Vet Pharmacol Therap1992，，15： | 1 |
| 10 | Crystal structures and cation distributions in simple spinels from powder XRD structural refinements:MgCr2O4,ZnCr2O4,Fe3O4 and the temperature dependence of the cation distribution in ZnAl2O4显示文摘 | O'Neill H St C Dollase W A | 1994 | Phys Chem Miner1994，20，8： | 1 |
| 11 | Co-occurrence of infantile epileptic seizures and childhood paroxysmal choreoathetosis in one family:clinical,EEG,and SPECT characterization of episodic events显示文摘 | Thiriaux A de St Martin A Vercueil L | 2002 | Mov Disord2002，79，1： | 1 |
| 12 | New Porous Sili-con Formation Technology Using Internal Current Gen-eration with Galvanic Elements显示文摘 | Splinter A Stürmann J Benecke W | 2001 | Sensors and Actu-ators2001，92，： | 1 |
| 13 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，96： | 1 |
| 14 | The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs 显示文摘 | Khan M A Herzog C A Peter J V St | 1998 | N Engl J Med1998，339，11： | 1 |
| 15 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 16 | Comparison of three probability formulae for parentage exclusion显示文摘 | Jamieson A Taylor St C S | 1997 | Animal Genetics1997，28，： | 1 |
| 17 | All si-lica single-mode optical fiber with photonic crystal cladding显示文摘 | Knight J C Birks T A Russell P St J | 1996 | Optics Letters1996，21，19： | 1 |
| 18 | Experimental petrochemistry of some highly siderophile elements at high temperatures, and some implication for ore formation and the mantles early history显示文摘 | ONEILL H ST C DINGWELL D B BORISOV A | 1995 | Chem Geol1995，120，： | 1 |
| 19 | All-silica single-mode optical fiber with photonic crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 20 | Late abscess formation following indirect hernia repair utilizing silk suture 显示文摘 | Calkins CM St Peter SD Balcom A | 2007 | Pediatr Surg Int2007，23，4： | 1 |
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