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| 1 | Colorectal cancer tumour markers and biomarkers:Recenttherapeutic advances显示文摘Colorectal cancer(CRC) is the second most commonly diagnosed cancer among females and third among males worldwide. It also contributes significantly to cancer-related deaths, despite the continuous progress in diagnostic and therapeutic methods. Biomarkers currently play an important role in the detection and treatment of patients with colorectal cancer. Risk stratification for screening might be augmented by finding new biomarkers which alone or as a complement of existing tests might recognize either the predisposition or early stage of the disease. Biomarkers have also the potential to change diagnostic and treatment algorithms by selecting the proper chemotherapeutic drugs across a broad spectrum of patients. There are attempts to personalise chemotherapy based on presence or absence of specific biomarkers. In this review, we update review published last year and describe our understanding of tumour markers and biomarkers role in CRC screening, diagnosis, treatment and follow-up. Goal of future research is to identify those biomarkers that could allow a non-invasive and cost-effective diagnosis, as well as to recognise the best prognostic panel and define the predictive biomarkers for available treatments. | Gustaw Lech Robert Słotwiński Maciej Słodkowski Ireneusz Wojciech Krasnodębski | 2016 | World Journal of Gastroenterology2016，22，5： | 33 |
| 2 | Brain-gut axis in the pathogenesis of Helicobacter pylori infection显示文摘Helicobacter pylori(H.pylori)infection is the main pathogenic factor for upper digestive tract organic diseases.In addition to direct cytotoxic and proinflammatory effects,H.pylori infection may also induce abnormalities indirectly by affecting the brain-gut axis,similar to other microorganisms present in the alimentary tract.The brain-gut axis integrates the central,peripheral,enteric and autonomic nervous systems,as well as the endocrine and immunological systems,with gastrointestinal functions and environmental stimuli,including gastric and intestinal microbiota.The bidirectional relationship between H.pylori infection and the brain-gut axis influences both the contagion process and the host’s neuroendocrine-immunological reaction to it,resulting in alterations in cognitive functions,food intake and appetite,immunological response,and modification of symptom sensitivity thresholds.Furthermore,disturbances in the upper and lower digestive tract permeability,motility and secretion can occur,mainly as a form of irritable bowel syndrome.Many of these abnormalities disappear following H.pylori eradication.H.pylori may have direct neurotoxic effects that lead to alteration of the brain-gut axis through the activation of neurogenic inflammatory processes,or by microelement deficiency secondary to functional and morphological changes in the digestive tract.In digestive tissue,H.pylori can alter signaling in the brain-gut axis by mast cells,the main brain-gut axis effector,as H.pylori infection is associated with decreased mast cell infiltration in the digestive tract.Nevertheless,unequivocal data concerning the direct and immediate effect of H.pylori infection on the brain-gut axis are still lacking.Therefore,further studies evaluating the clinical importance of these host-bacteria interactions will improve our understanding of H.pylori infection pathophysiology and suggest new therapeutic approaches. | Jacek Budzyński Maria Kopocka | 2014 | World Journal of Gastroenterology2014，20，18： | 29 |
| 3 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 4 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 5 | Synthesis of BiOCl photocatalyst by a low-cost,simple hydrolytic technique and its excellent photocatalytic activity显示文摘A novel photocatalyst,bismuth oxychloride(BiOCl) micro-nano particles with a fine ferrite plate structure,was prepared by a low-cost,simple hydrolytic method.The as-prepared BiOCl was characterized by scanning electron microscopy(SEM),thermogravimetric analysis-differential thermal analysis(TGA-DTA),X-ray diffraction(XRD),and UV-vis diffuse reflectance spectra(DRS).The effects of preparation conditions such as sodium dodecyl benzene sulfonate(SDBS) dispersant,HCl concentration,and heat treatment temperature on BiOCl performances were investigated.Moreover,its photocatalytic activity was evaluated on the degradation of methylene orange(MO) and was compared with that of TiO 2(P25).The experimental results confirmed that BiOCl micro-nano particles prepared with SDBS,the HCl concentration of 1.5 mol/L,and the heat treatment temperature of 80°C exhibited the best performance for the photodegradation of MO solution,and they showed good stability and better photocatalytic activity than P25 photocatalyst. | Yan Wang Zhu-qing Ski Cai-mei Fan Xiao-gang Hao Guang-yue Ding Yun-fang Wang | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，5： | 11 |
| 6 | Cholesky分解递归算法与改进显示文摘递归算法是计算稠密线性代数的一种新的有效方法 .递归产生自动、变化的矩阵分块 ,能充分发挥当今分级存储高性能计算机的效率 .对 Cholesky分解递归算法进行了研究 ,给出了算法的详细推导过程 ,用具有递归功能的 Fortran 90实现了算法 ,并通过矩阵元素顺序重排的方法 ,进一步提高了递归算法的运算速度 .研究产生的算法比目前常用的分块算法快 15 %~ 2 5 % . | 陈建平 Jerzy Wasniew ski | 2001 | 计算机研究与发展2001，38，8： | 11 |
| 7 | Recurrent inflammatory fibroid polyp of cardia:A case report显示文摘Inflammatory fibroid polyp is one of the chronic inflammatory diseases in the digestive tract, which often mimics the submucosal tumor. Precise diagnosis is possible after removal of the detected lesion. Endoscopic removal is recommended as a safe and efficient method of the treatment. In this report the authors present a case of inflammatory fibroid polyp located in the cardia, which has been removed endoscopically. Twelve months later, recurrence of the lesion was noted and the patient was referred to surgical resection. | Krzysztof Zinkiewicz Witold Zgodziski Andrzej D~1browski Justyna Szumi~3o Grzegorz AEwik Grzegorz Wallner | 2004 | World Journal of Gastroenterology2004，10，5： | 7 |
| 8 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 9 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 10 | 圆筒实验数据研究高能炸药的爆轰特性(英文)显示文摘根据圆筒实验数据,采用新方法计算了HMX、RDX、PETN、TNT等炸药的爆轰能,研究了爆轰产物的加速能力,并与CHEETAH的计算结果进行了对比。通过爆轰波在柱壳水介质中传播的圆筒实验方法,预估了炸药的爆压。利用实验和热化学计算的结果推导了JWL状态方程的待定常数,并依据JWL等熵线计算了做功能力。 | Waldemar A Trzciński Stanisaw Cudzio | 2006 | 含能材料2006，14，1： | 6 |
| 11 | 28个绿芦笋品种的适应性评价(英文)显示文摘[目的]本文旨在对波兰气候条件下的28个绿芦笋品种进行适应性评价,并选择出最适合在波兰种植的品种。[方法]2008年在马赛林试验站对第六年收获的28个品种的绿芦笋进行评价。收获期间,将收获的芦笋嫩茎,剪至22cm,分级,称重,同时对嫩茎外观、花青素变化、芦笋头紧实性、颜色及光滑度等性状进行评估。[结果‘]Gynlim’是产量最高的品种,其次为‘Hannibal’,‘Ravel’,‘Grolim’和‘Ramada’。‘Gloria’是最差的品种,其它最差的品种以次为‘Tsuki-kho3’、‘PurplePassion’、‘Jacq.Ma2014’、‘Sartaguda’、和‘Jacq.Ma2004’。‘Gynlim’、‘Hannibal’、‘Ravel’、‘Ramada’、‘Ariane’是前期产量最高的前5个品种。前期产量最差的品种为‘PLA-2132’,随后是‘Ramos’、‘Tsuki-kho3’和‘PurplePassion’。‘Ariane’、‘Cipress’、‘Grolim’、‘Gynlim’和‘Hannibal’的嫩茎质量最好。嫩茎质量最差的品种依次是‘Jacq.Ma2004’、‘Gloria’、‘Jacq.Ma2014’和‘Tsuki-kho3’。[结论]综合考虑产量与质量,在波兰气候条件下,最适宜的绿芦笋品种为‘Gynlim’、‘Hannibal’、‘Ravel’和‘Grolim’,而‘Gloria’、‘Tsuki-kho3’、‘PurplePassion’、‘Jacq.Ma2014’和‘Sartaguda’不适合波兰种植。 | 祝清俊 陈蕾蕾 孙欣 张奇志 Mikolaj Knaflewski Wodzimierz Krzesiński | 2013 | Agricultural Science & Technology2013，14，2： | 5 |
| 12 | Changes in Lake Ice Cover on the Morskie Oko Lake in Poland(1971-2007)显示文摘根据从时期 1971-2007 的数据,并且由适用,湖冰的趋势分析,形成上的研究,消失和持续时间在南部的波兰在 Tatra 山在默斯基·奥科·莱克上盖住被执行。结果在冬季湖冰盖子的最大的厚度并且在湖冰现象的持续时间显示出减少的趋势,当在 Tatra 山的脚在一样的时期记录的空气温度显示出增加的趋势时。在湖冰现象和空气温度的功课之间有强壮的关系。 | Adam Choiński Leszek Kolendowicz Joanna Pociask-Karteczka Leszek Sobkowiak | 2010 | Advances in Climate Change Research2010，1，2： | 4 |
| 13 | Limit on the production of a light vector gauge boson in ? meson decays with the KLOE detector显示文摘 | D. Babusci D. Badoni I. Balwierz-Pytko G. Bencivenni C. Bini C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl G. Capon F. Ceradini P. Ciambrone E. Czerwiński E. Danè E. De Lucia G. De Robertis A. De Santis A. Di Domenico C. Di Donato R. Di | 2013 | Physics Letters B2013，，： | 4 |
| 14 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 15 | Search for light vector boson production in e + e ? → μ + μ ? γ interactions with the KLOE experiment显示文摘 | D. Babusci I. Balwierz-Pytko G. Bencivenni C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl F. Ceradini P. Ciambrone F. Curciarello E. Czerwiński E. Danè V. De Leo E. De Lucia G. De Robertis A. De Santis P. De Simone A. Di Cicco A. Di Dome | 2014 | Physics Letters B2014，，： | 3 |
| 16 | Search for a dark photon in the π 0 → e + e ? γ decay显示文摘 | P. Adlarson W. Augustyniak W. Bardan M. Bashkanov F.S. Bergmann M. Ber?owski H. Bhatt A. Bondar M. Büscher H. Calén I. Ciepa? H. Clement D. Coderre E. Czerwiński K. Demmich E. Doroshkevich R. Engels W. Erven W. Eyrich P. Fedorets K. F?hl K. Fransson F. Go | 2013 | Physics Letters B . 2013 (1-3)2013，，1： | 3 |
| 17 | 严重肢体缺血患者血浆中促血管生成潜力与血浆MMP-9、TIMP-1和TIMP-2水平升高的相关性研究(英文)显示文摘本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会显著增加,同时依赖于循环受体sVEGFR-1和sVEGFR-2的抑制也会显著减少.与IC病人相比,CLI病人具有较高的VEGF-A、金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)和TIMP-2浓度. | Radoslaw Wieczór Anna Maria Wieczór Arleta Kulwas Grzegorz Pulkowski Jacek Budzyński Danuta Rosc | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，8： | 3 |
| 18 | Evaluating causal relations in neural systems: Granger causality, directed transfer function and statistical assessment of significance显示文摘 | Maciej Kamiński Mingzhou Ding Wilson A. Truccolo Steven L. Bressler | 2001 | Biological Cybernetics2001，，2： | 3 |
| 19 | Impact of atmospheric turbulence on coherent beam combining for laser weapon systems显示文摘The performance of a laser weapon system based on coherent beam combining(CBC)depends on its propagation properties in the atmosphere.In this study,an analytical model based on partial coherent beam combining(PCBC)for assumed coherence coefficients between beams in a CBC lattice was developed.The Kolmogorov model of atmospheric turbulence and the Hufnagel-Valley model of C^(2)_(n) dependence on atmospheric parameters were implemented.Novel simplified metrics were proposed to assess the CBC performance.Several beam profiles(super-Gaussian,truncated Gaussian,etc.)and geometries were analyzed in terms of maximal intensity in the far field.An approximate formula for PCBC efficiency dependent on the Fried radius was proposed.The results of CBC modeling were compared to those of the Gaussian beam propagation model in a turbulent atmosphere.The dependence of CBC performance on the C^(2)_(n) parameter,range,and elevation angle was analyzed.It could be concluded that the application of CBC for medium and long range propagation is impractical without an effective adaptive optics system. | Jan K.Jabczyński Przemysław Gontar | 2021 | Defence Technology(防务技术)2021，17，4： | 3 |
| 20 | Modelling of CCT diagrams for engineering and constructional steels显示文摘 | J. Trzaska L.A. Dobrzański | 2007 | Journal of Materials Processing Tech2007，，： | 2 |
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