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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 3 | Endosonographic diagnosis of submucosal upper gastrointestinal tract lesions and large fold gastropathies by catheter ultrasound probe 显示文摘 | Elisabetta B Michele DS Sandro R | 1999 | Gastrointestional Endoscopy1999，49，2： | 1 |
| 4 | Radiation exposure from diagnostic imaging in severely injured trauma patients显示文摘 | Homer C Lorraine N Sandro B | 2007 | J Trauma2007，62，1： | 1 |
| 5 | Peptide permeases from Streptococcus pneumoniae affect adherence to eucaryotic cells显示文摘 | Cundell D R Pearce B J Sandros J etal | 1995 | Infect Immun1995，63，7： | 1 |
| 6 | Peptide permeases from Streptococcus pneumoniae affect adherence to eucaryotic cells显示文摘 | Cundell D R Pearce B J Sandros J | 1995 | Infect Immun1995，63，7： | 1 |
| 7 | Radiographic characteristics of furcation involvements in mandibular molars as prognostic indicators of healing after nonsurgical periodontal therapy显示文摘 | HUGO F D V 6RIEA D P R SANDRO B | 2009 | J Am Dent Assoc2009，140，4： | 1 |
| 8 | Histone Deacetylase Inhibitors显示文摘 | Thomas AM David JW sandro B | 2003 | J med chem2003，46，24： | 1 |
| 9 | Molecular cloning and characterization of a mouse homologs of bacterial ClpX,a novel mammalian class Ⅱ member of the Hsp100/Clp chaperone family显示文摘 | Sandro S Debida B FU-HOU W | 1999 | The Journal of Biological Chemistry1999，273，16： | 1 |
| 10 | HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects显示文摘 | Enzo B Sandro P Gianni F | 2002 | Diabetes Care2002，25，7： | 1 |
| 11 | Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae 显示文摘 | Spellerberg B Cundell D R Sandros J | 1996 | Mol Micro- biol1996，19，4： | 1 |
| 12 | Endosonographic diagnosis of submucosal upper gastrointestinal tract lesions and large fold gastropathies by catheter ultrasound probe 显示文摘 | Elisabetta B Michele DS Sandro R | 1999 | Gastrointes Endosc1999，49，2： | 1 |
| 13 | Cerium dioxide nanoparticles can interfere with the associ- ated cellular mechanistic response to diesel exhaust expo- sure 显示文摘 | Sandro Steine Loretta Mueller Popovicheva Olga B | 2012 | Toxicology Letters2012，214，： | 1 |
| 14 | Endosonographic diagnosis of submucosal upper gastrointestinal tract lesions and large fold gastropathies by catheter ultrasound probe显示文摘 | Elisabetta B Michele DS Sandro R | 1999 | Gastrointestional Endoscopy1999，49，2： | 1 |
| 15 | Fish oil alters T lym phocyte proliferation and maerophage responses in walker 256 tumor-bearing rats 显示文摘 | Nathalia P Sandro B Maressa P | 2006 | Nutrition2006，22，： | 1 |
| 16 | Radiation exposure from diag- nostic imaging in seeverly injured trauma patients 显示文摘 | Homer C Lorraine N Sandro B | 2007 | J Trauma2007，62，1： | 1 |
| 17 | Full-mouth untra- sonic dehridement associated with amoxicillin and metron- idazole in the treatment of severe chronic periodontitis 显示文摘 | Erica DPR Sandro B Iriana CJZ | 2009 | J Periodontol2009，80，8： | 1 |
| 18 | The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock显示文摘 | Sandro B | 2006 | Ann Surg2006，243，1： | 1 |
| 19 | Synthesis and full characterization of nikel ( Ⅱ ) colloidal particles and their transformation into NiO 显示文摘 | Francesca P Sandro R Claudia B | 1999 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1999，155，23： | 1 |
| 20 | Fish oil alters T-lymphocyte proliferation and macrophage re- sponses in Walker 256 tumor-bearing rats 显示文摘 | Nathalia P Sandro B Maressa P | 2006 | Nutrition2006，22，： | 1 |
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