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| 1 | Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management显示文摘Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative therapy.In the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major vessel.Obviously,surgical exploration with pathological examination remains the'gold standard'in terms of evaluation of resectability,especially from the point of view of vascular involvement.However,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively reliable.Nevertheless,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion.Although the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a contraindication.Detection of vascular invasion remains one of the most important challenges in pancreatic surgery.The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer. | Nicolas C Buchs Michael Chilcott Pierre-Alexandre Poletti Leo H Buhler Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，7： | 29 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 4 | Recurrent Clostridium difficile infections:The importance of the intestinal microbiota显示文摘Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial diarrhea.Despite effective antibiotic treatments,recurrent infections are common.With the recent emergence of hypervirulent isolates of C.difficile,CDI is a growing epidemic with higher rates of recurrence,increasing severity and mortality.Fecal microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic approach.FMT is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent CDI.Since the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic treatment.This article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability. | Marie Céline Zanella Terrier Martine Louis Simonet Philippe Bichard Jean Louis Frossard | 2014 | World Journal of Gastroenterology2014，20，23： | 5 |
| 5 | Polymeric foams for flexible and highly sensitive low-pressure capacitive sensors显示文摘Flexible low-pressure sensors(<10 kPa)are required in areas as diverse as blood-pressure monitoring,human–computer interactions,robotics,and object detection.For applications,it is essential that these sensors combine flexibility,high sensitivity,robustness,and low production costs.Previous works involve surface micro-patterning,electronic amplification(OFET),and hydrogels.However,these solutions are limited as they involve complex processes,large bias voltages,large energy consumption,or are sensitive to evaporation.Here,we report a major advance to solve the challenge of scalable,efficient and robust e-skin.We present an unconventional capacitive sensor based on composite foam materials filled with conductive carbon black particles.Owing to the elastic buckling of the foam pores,the sensitivity exceeds 35 kPa^(−1) for pressure<0.2 kPa.These performances are one order of magnitude higher than the ones previously reported.These materials are low-cost,easy to prepare,and display high capacitance values,which are easy to measure using low-cost electronics.These materials pave the road for the implementation of e-skin in commercialized applications. | Mickaël Pruvost Wilbert J.Smit Cécile Monteux Philippe Poulin Annie Colin | 2019 | npj Flexible Electronics2019，3，1： | 5 |
| 6 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 7 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 8 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 9 | Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care显示文摘AIM:To describe and analyse factors associated with Clostridium difficile infection(CDI)severity in hospitalised medical intensive care unit patients.METHODS:We performed a retrospective cohort study of 40 patients with CDI in a medical intensive care unit(MICU)at a French university hospital.We include patients hospitalised between January 1,2007and December 31,2011.Data on demographics characteristics,past medical history,CDI description was collected.Exposure to risk factors associated with CDI within 8 wk before CDI was recorded,including previous hospitalisation,nursing home residency,antibiotics,antisecretory drugs,and surgical procedures.RESULTS:All included cases had their first episode of CDI.The mean incidence rate was 12.94 cases/1000admitted patients,and 14.93,8.52,13.24,19.70,and8.31 respectively per 1000 admitted patients annually from 2007 to 2011.Median age was 62.9[interquartile range(IQR)55.4-72.40]years,and 13(32.5%)were women.Median length of MICU stay was 14.0d(IQR 5.0-22.8).In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 patient.The duration of diarrhoea was 13.0(8.0-19.5)d.In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 patient.Prior to CDI,38patients(95.0%)were exposed to antibiotics,and 12(30%)received at least 4 antibiotics.Fluoroquinolones,3rdgeneration cephalosporins,coamoxiclav and tazocillin were prescribed most frequently(65%,55%,40%and 37.5%,respectively).The majority of cases were hospital-acquired(n=36,90%),with 5 cases(13.9%)being MICU-acquired.Fifteen patients had severe CDI.The crude mortality rate within 30 d after diagnosis was 40%(n=16),with 9 deaths(9 over 16;56.3%)related to CDI.Of our 40 patients,15(37.5%)had severe CDI.Multivariate logistic regression showed that male gender[odds ratio(OR):8.45;95%CI:1.06-67.16,P=0.044],rising serum C-reactive protein levels(OR=1.11;95%CI:1.02-1.21,P=0.021),and previous exposure to fluoroquinolones(OR=9.29;95%CI:1.16-74.284,P=0.036)were independently associated with severe CDI.CONCLUSION:We report predictors of severe CDI not dependent on time of assessment.Such factors could help in the development of a quantitative score in ICU’s patients. | Nagham Khanafer Abdoulaye Touré Cécile Chambrier Martin Cour Marie-Elisabeth Reverdy Laurent Argaud Philippe Vanhems | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 10 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 11 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas 显示文摘 | Philipp W Speicher L Humpet C | 2000 | Invest Ophthalmol Vis Sci2000，41，： | 1 |
| 12 | Efficient inhibition of hepatitis B virus infection by acylated peptides derived fa'om the large viral surface protein显示文摘 | Philippe G Isabelle C and Stephan U | 2005 | J Virol2005，79，3： | 1 |
| 13 | Nacylhomoserine lactones undergo lactonolysis in a pH-,temperature-,and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa显示文摘 | YATES E A PHILIPP B BUCKLEY C | 2002 | Infect Immun2002，70，： | 1 |
| 14 | Mass tuansfer,clearanceand plasma concentration of procalcitonin during continuousvenovenous hemofiltration in patients with septic shock andacute oliguric renal failure显示文摘 | Claude L Philippe C Olivier G | 2003 | Critical Care2003，6，7： | 1 |
| 15 | Generation of hierar- chical meso- and macroporous carbon from mesophase pitch by spinodal decomposition using polymer templates 显示文摘 | Philipp A Hu Y S Laemthong C | 2007 | Advanced Materials2007，19，22： | 1 |
| 16 | Anfi-inflam matory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation 显示文摘 | Riedel C U Foam F Philippe D | 2006 | World J Gastroenterol2006，2，23： | 1 |
| 17 | Performance comparision of asynchronous and synchronous CDMA techniques for fiber-optic local area networks显示文摘 | Kwong Wing C Perrier Philippe A Prucnal Paul R | 1991 | IEEE Trans Commun1991，39，11： | 1 |
| 18 | Recent extraction techniques for natural products:microwave-assisted extraction and pressurised solvent extraction显示文摘 | Be′atrice K Philippe C | 2002 | Phytochemical analysis2002，13，： | 1 |
| 19 | Antibodies to acetylcholinesterase cross-reacting with thyroglobulin in myasthenia gravis and Graves'disease显示文摘 | Mappouras DG Philippou C Haralambous S | 1995 | Clin Exp Immunol1995，100，2： | 1 |
| 20 | Recovery of a persistent Canine distemper virus expressing the enhanced green fluorescent protein from cloned cDNA显示文摘 | Philippe Zweifel C Wiederkehr C | 2004 | Virus Res2004，101，2： | 1 |
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