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| 1 | Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy显示文摘AIM: To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy(EUS-FNAB) without cytology and mucosal cutting biopsy(MCB) in the histological diagnosis of gastric submucosal tumor(SMT).METHODS: We prospectively compared the diagnostic yield, feasibility, and safety of EUS-FNAB and those of MCB based on endoscopic submucosal dissection. The cases of 20 consecutive patients with gastric SMT ≥1 cm in diameter. who underwent both EUS-FNAB and MCB were investigated.RESULTS: The histological diagnoses were gastrointestinal stromal tumors(n = 7), leiomyoma(n =6), schwannoma(n = 2), aberrant pancreas(n = 2), and one case each of glomus tumor, metastatic hepatocellular carcinoma, and no-diagnosis. The tumors' mean size was 23.6 mm. Histological diagnosis was made in 65.0% of the EUS-FNABs and 60.0% of the MCBs, a nonsignificant difference. There were no significant differences in the diagnostic yield concerning the tumor location or tumor size between the two methods. However, diagnostic specimens were significantly more frequently obtained in lesions with intraluminal growth than in those with extraluminal growth by the MCB method(P = 0.01). All four SMTs with extraluminal growth were diagnosed only by EUSFNAB(P = 0.03). No complications were found in either method.CONCLUSION: MCB may be chosen as an alternative diagnostic modality in tumors showing the intraluminal growth pattern regardless of tumor size, whereas EUSFNAB should be performed for SMTs with extraluminal growth. | Hisatomo Ikehara Zhaoliang Li Jiro Watari Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Toshihiko Tomita Tadayuki Oshima Hirokazu Fukui Ikuo Matsuda Seiichi Hirota Hiroto Miwa | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，14： | 7 |
| 2 | Prospective postsurgical capsule endoscopy in patients with Crohn's disease显示文摘AIM: To clarify the usefulness of postsurgical capsule endoscopy(CE) in the diagnosis of recurrent small bowel lesions of Crohn's disease(CD). METHODS: This prospective study included 19 patients who underwent ileocolectomy or partial ileal resection for CD. CE was performed 2-3 wk after surgery to check for the presence/absence and severity of lesions remaining in the small bowel, and for any recurrence at the anastomosed area. CE was repeated 6-8 mo after surgery and the findings were compared with those obtained shortly after surgery. The Lewis score (LS) was used to evaluate any inflammatory changes of the small bowel. RESULTS: One patient was excluded from analysis because of insufficient endoscopy data at the initial CE. The total LS shortly after surgery was 428.3 on average(median, 174; range, 8-4264), and was ≥ 135(active stage) in 78%(14 of 18) of the patients. When the remaining unresected small bowel was divided into 3 equal portions according to the transition time(proximal, middle, and distal tertiles), the mean LS was 286.6, 83.0, and 146.7, respectively, without any significant difference. Ulcerous lesions in the anastomosed area were observed in 83% of all patients. In 38% of the 13 patients who could undergo CE again after 6-8 mo, the total LS was higher by ≥ 100 than that recorded shortly after surgery, thus indicating a diagnosis of endoscopic progressive recurrence. CONCLUSION: Our pilot study suggests that CE can be used to objectively evaluate the postoperative recurrence of small bowel lesions after surgery for CD. | Tomoaki Kono Nobuyuki Hida Koji Nogami Masaki Iimuro Yoshio Ohda Yoko Yokoyama Koji Kamikozuru Katsuyuki Tozawa Mikio Kawai Tomohiro Ogawa Kazutoshi Hori Hiroki Ikeuchi Hiroto Miwa Shiro Nakamura Takayuki Matsumoto | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 3 | Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study显示文摘AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD. | Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，12： | 4 |
| 4 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 5 | Analysis of Pichia pastoris components in recombinant human serum albumin by immunological assays and by HPLC with pulsed amperometric detection显示文摘 | OHTANI W OHDA T SUMI A | 1998 | Anal Chem1998，70，： | 1 |
| 6 | Evaluation of discomfort during colonoscopy- with conventional and uhrathin colonoscopes in ulcerativecolitis patients显示文摘 | Ogawa T Ohda Y Nagase K | 2015 | Dig Endosc2015，27，1： | 1 |
| 7 | Serum cystatin C May predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy显示文摘 | Tomino Y Suzuki S ( ohda T | 2001 | J Clin Lab Anal2001，15，1： | 1 |
| 8 | Development of a fed-batch culture process for enhanced production of recombinant human an- tithrombin by Chinese hamster ovary cells 显示文摘 | Kuwae S Ohda T Tamashima H | 2005 | J Biosci Bioeng2005，100，5： | 1 |
| 9 | Effects of hepatocyte growth factor on rat inflammatory bowel disease models显示文摘 | Ohda Y Hori K Tomita T | 2005 | Dig Dis Sci2005，50，： | 1 |
| 10 | Development of a fedbatch culture process for enhanced production of recombinant human antithrombin by chinese hamster ovary cells显示文摘 | Kuwae S Ohda T Tamashima H | | 0，，05： | 1 |
| 11 | The expression profile of functional regulatory T cells,CD4+CD25high+/forkhead box protein P3+,in patients with ulcer-ative colitis during active and quiescent disease显示文摘 | Kamikozuru K Fukunaga K Hirota S Hida N Ohda Y Yoshi-da K | 2009 | Clin Exp Im-munol2009，156，2： | 1 |
| 12 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 13 | Development of a Fed-batch Culture Process for Enhanced Production of Recombinant Human Antithrombin by Chinese hamster ovary cells显示文摘 | Kuwae S Ohda T Tamashima H | 2005 | J Biosci Bioeng2005，100，： | 1 |
| 14 | Effects of hepatocyte growth factor on rat inflammatory bowel disease models显示文摘 | Ohda Y Hori K Tomita T | 2005 | Dig Dis Sci2005，50，5： | 1 |
| 15 | A u nique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals显示文摘 | Taguchi Y G ohda J K oga T T akayanagi H Inoue J | | 0，，： | 1 |
| 16 | The expression profile of functional regulatory T cells, CD4 + CD25hlgh+/forkhead box protein P3 + , in patients with ul- cerative colitis during active and quiescent disease显示文摘 | Kamikozuru K Fukunaga K Hirota S Hida N Ohda Y Yoshida K | 2009 | Clin Exp lmmunol2009，156，2： | 1 |
| 17 | Analysis of Pichia pastoris components in recombinant human serum albumin by immunological assays and by HPLC with pulsed amperometric detection显示文摘 | Ohtani W Ohda T Sumi A | 1998 | Anal Chem1998，70，： | 1 |
| 18 | The CD4 + CD28 null and the regulatory CD4 + CD25 High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy显示文摘 | Yoko Yokoyama Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Masaki Iimuro Koji Yoshida Risa Kikuyama Kyouichi Kato Kazuko Nagase Shirou Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Cytokine2011，，2： | 1 |
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