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| 1 | Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma显示文摘AIM: To investigate the precise role of membrane type1-matrix metalloproteinase (MT1-MMP) in hepatocellular carcinoma (HCC) metastasis.METHODS: Human HCC cells Hep3B with overexpression of MT1-MMP were established by stable transfection, and compared with control cells carrying the empty vector.Cells were examined in vivo for their differences in the metastatic ability of athymic nude mice, and analyzed in vitro for their differences in invasion ability by invasion chamber coated with Matrigel, adhesion towards collagen I and migration through culture chamber. Cell proliferation and apoptosis in adherent and suspension status were evaluated by MTT and flow cytometry analysis.RESULTS: We found that overexpression of MT1-MMP could increase intrahepatic metastasis in nude mice with orthotopic implantation of HCC cells (incidence of 100%[MT1-MMP transfectants] vs 40% [vector control transfectants], P<0.05). MT1-MMP could also enhance cell invasion through Matrigel (107.7 vs 39.3 cells/field,P<0.001), adhesion towards matrix (0.30 vs 0.12absorbance unit at 540 nm, P<0.001), cell migration(89.3 vs 39.0 cells/field, P<0.001), and cell proliferation(24.3 vs 40.5 h/doubling, P<0.001). We also observed that MT1-MMP supported cell survival (71.4% vs 23.9%,P<0.001) with reduced apoptosis (43.7% vs51.0%, P<0.05)in an attachment-free environment.CONCLUSION: MT1-MMP overexpression could enhance metastasis. In addition to its active role in matrix degradation during tumor invasion, MT1-MMP enhances tumor cell survival upon challenge of detachment, which is important during metastasis when cells enter the circulation. | Ying-Chi Ip Siu-Tim Cheung Ka-Ling Leung Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，40： | 11 |
| 2 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 3 | 探讨卵巢和子宫的子宫内膜样癌、伴透明细胞改变子宫内膜样癌和透明细胞癌的免疫表型显示文摘准确的鉴别透明细胞癌和子宫内膜样癌有着非常重要的临床意义,部分内膜样癌伴透明细胞改变,可以模拟透明细胞癌。作者评估一组免疫组化标志物能否帮助鉴别这几种肿瘤。64例透明细胞癌(40例来源卵巢和24例来源子宫)、34例内膜样癌(21例来源卵巢和13例来源子宫)及34例内膜样癌伴透明细胞改变(6例来源卵巢和28例来源子宫),免疫组化标记HNF1β、BAF250a、Napsin A、ER和PR,并对免疫组化着色强度和范围进行评估。 | Lim D Ip P P Cheung A N 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，9： | 9 |
| 4 | RFID技术与应用中的建模与优化的研究综述显示文摘RFID与传感器网络是物联网的基础技术。随着RFID的广泛应用,产生了许多新的建模与优化的问题。分别从RFID技术和应用两个方面对这些新问题的研究情况进行综述。主要问题包括:读卡器网络的布置优化,读卡器负荷平衡,RFID存储的数据分配,高速读入的防碰撞算法,RFID系统的投资回报的分析与决策,RFID带来的业务流程再造问题,供应链中的存储优化问题,个件层(Item-Level)管理带来的新问题,动态信息与快速响应的新问题等。 | 汪定伟 Ip W H | 2013 | 控制工程2013，20，1： | 7 |
| 5 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 6 | Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease显示文摘Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction. | Zhongqi Li Bonaventure Ip Vincent C.T.Mok Ho Ko | 2021 | Neural Regeneration Research2021，16，12： | 3 |
| 7 | Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography显示文摘AIM: To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field(UWF) fluorescein angiography(FA).METHODS: Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200 Tx. Images obtained at different gaze angles stereographically projected and montaged. The early-phase UWF FA frames were processed to segment the retinal vasculature and the results were exported as binary masks. The fractal dimension(FD) was calculated using the box-counting method.RESULTS: The global FD for the entire retina was 1.6±0.04, with no difference between males and females(1.59±0.04 vs 1.61±0.04, P=0.084) or between right and left eyes(1.6±0.04 vs 1.6±0.05, P=0.61). FD was nonuniformly distributed among four quadrants(P<0.001) and decreased as the distance from the fovea increased(P<0.001). A negative association was observed between FD and age(R=-0.37, P=0.006), and this relationship was observed in the posterior and mid-peripheral retina(P<0.05) but absent in far-periphery(P>0.05).CONCLUSION: Fractal geometry is non-uniformly distributed across the retina in normal eyes and decreases from the fovea to the far-periphery. Subjects with an older age tend to have a smaller FD, however, the FD in the farperiphery does not appear to be influenced by age. | Wen-Ying Fan Alan Fleming Gavin Robertson Akihito Uji Jano van Hemert Michael Singer Min Sagong Michael Ip SriniVas R.Sadda | 2020 | International Journal of Ophthalmology(English edition)2020，13，7： | 3 |
| 8 | Census of Kuiper Comets-the TAOS Project显示文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ~ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year. | Wen Ping ChenOther TAOS team members: C. Alcock, K. Cook, S. Marshall, M. Hammergren(LLNL) T. Lee, C. Yuan, C. Y. Wen, S. K. King(ASIAA) W. S. Tsay, W. Ip, C. Lemme, J. H. Wang(NCU) T. Axelrod(ANU) I. de Pater(UCB) J.Lissauer(Ames) Y. I. Byun(Yonsei | 1999 | 天文研究与技术1999，，S1： | 3 |
| 9 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 10 | Reconstruction of lateral root formation through single-cell RNA sequencing reveals order of tissue in itiation显示文摘Postembryonic organogenesis is critical for plant development.Underground,lateral roots(LRs)form the bulk of mature root systems,yet the ontogeny of the LR primordium(LRP)is not clear.In this study,we performed the single-cell RNA sequencing through the first four stages of LR formation in Arabidopsis.Our analysis led to a model in which a single group of precursor cells,with a cell identity different from their pericycle origins,rapidly reprograms and splits into a mixed ground tissue/stem cell niche fate and a vascular precursor fate.The ground tissue and stem cell niche fates soon separate and a subset of more specialized vascular cells form sucrose transporting phloem cells that appear to connect to the primary root.We did not detect cells resembling epidermis or root cap,suggesting that outer tissues may form later,preceding LR emergence.At this stage,some remaining initial precursor cells form the primordium flanks,while the rest create a reservoir of pluripotent cells that are able to replace the LR if damaged.Laser ablation of the central and lateral LRP regions showed that remaining cells restart the sequence of tissue initiation to form a LR.Collectively,our study reveals an ontological hierarchy for LR formation with an early and sequential split of main root tissues and stem cells. | Laura Serrano-Ron Pablo Perez-Garcia Alvaro Sanchez-Corrionero Inmaculada Gude Javier Cabrera Pui-Leng Ip Kenneth D.Birnbaum Miguel A.Moreno-Risueno | 2021 | Molecular Plant2021，14，8： | 2 |
| 11 | A community study of sleepdisordered breathing in middle aged Chinese men in Hong Kong显示文摘 | Ip M Lam B Lauder IJ | | 0，，： | 2 |
| 12 | HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma显示文摘 | Man–Fung Yuen Danny Ka–Ho Wong James Fung Philip Ip David But Ivan Hung Kevin Lau John Chi–Hang Yuen Ching–Lung Lai | 2008 | Gastroenterology2008，，4： | 2 |
| 13 | Transpupillary thermotherapy显示文摘 | Ip M Croll A Reichel E | 1999 | Semi in Ophthalmol1999，14，： | 2 |
| 14 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 15 | Anti–Vascular Endothelial Growth Factor Pharmacotherapy for Diabetic Macular Edema显示文摘 | Allen C. Ho Ingrid U. Scott Stephen J. Kim Gary C. Brown Melissa M. Brown Michael S. Ip Franco M. Recchia | 2012 | Ophthalmology2012，，10： | 2 |
| 16 | Single Machine Group Scheduling Problems with the Effects of Deterioration and Learning显示文摘 | YAN Yang WANG Da-Zhi WANG Ding-Wei W. H. Ip WANG Hong-Feng | 2009 | 自动化学报2009，35，10： | 2 |
| 17 | Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration显示文摘在果蝇成年 midgut 的肠的干细胞(ISC ) 为维持织物动态平衡是必要的,并且他们的增长和区别加快以便为填满遇见需求响应损害的失去的房间。包括 JAK-STAT, EGFR 和河马(Hpo ) 小径的几个发信号小径在导致损坏的 ISC 增长被含有,但是集成这些小径的机制留下了逃犯。这里,我们证明 oncoprotein Myc (dMyc ) 的果蝇相当或相同的事物这些下游地工作表明小径调停他们 ISC 增长上的效果。在先锋房间的 dMyc 表示响应织物损坏被刺激,并且 dMyc 为加速的 ISC 增长和 midgut 新生是必要的。我们证明葡聚糖硫酸盐钠喂引起的那织物损坏经由 Hpo 小径刺激 dMyc 表示,而喂的 bleomycin 通过 JAK-STAT 和 EGFR 小径激活 dMyc。我们提供 dMyc 表示是的证据 transcriptionally 由多重发信号的小径的 upregulated,它响应织物为最佳的 ISC 增长被要求损坏。我们也获得了证据那织物损坏罐头 upregulate dMyc 表情 post-transcriptionally。最后,我们证明 dMyc 表示的基础水平在正常织物动态平衡期间为 ISC 维护,增长和系区别被要求。 | Fangfang Ren Qing Shi Yongbin Chen Alice Jiang Y Tony Ip Huaqi Jiang Jin Jiang | 2013 | Cell Research2013，23，9： | 2 |
| 18 | Testing heteroscedasticity by wavelets in a nonparametric regression model显示文摘In the nonparametric regression models, a homoscedastic structure is usually assumed. However, the homoscedasticity cannot be guaranteed a priori. Hence, testing the heteroscedasticity is needed. In this paper we propose a consistent nonparametric test for heteroscedasticity, based on wavelets. The empirical wavelet coefficients of the conditional variance in a regression model are defined first. Then they are shown to be asymptotically normal, based on which a test statistic for the heteroscedasticity is constructed by using Fan's wavelet thresholding idea. Simulations show that our test is superior to the traditional nonparametric test. | IP Waicheung | 2006 | Science China Mathematics2006，49，9： | 2 |
| 19 | Fluocinolone Acetonide Intravitreal Implant for Diabetic Macular Edema: A 3-Year Multicenter, Randomized, Controlled Clinical Trial显示文摘 | P. Andrew Pearson Timothy L. Comstock Michael Ip David Callanan Lawrence S. Morse Paul Ashton Brian Levy Eric S. Mann Dean Eliott | 2011 | Ophthalmology2011，，8： | 2 |
| 20 | 慢性阻塞性肺疾病急性加重患者感染性致病因素分析显示文摘背景和目的:反复急性发作是慢性阻塞性肺疾病(COPD)的临床特点,同时也是患者住院的主要原因,呼吸道感染常常是急性发作的诱因。适当的经验性应用抗生素对于降低此类患者的住院率和病死率非常有意义。不同居住地的COPD患者引起急性发作的病原谱是不同的,因而地区性资料对于指导临床治疗很重要。本研究的目的是阐明我国香港地区COPD急性发作的病原学及其治疗。方法:研究人员分析了我国香港2004年5月至2005年4月因COPD急性发作而住院的患者, | Ko FW Ip M Chan PK 李翠联 曹彬 | 2007 | 中华结核和呼吸杂志2007，30，5： | 2 |
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