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| 1 | Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer显示文摘AIM: To compare the efficacy of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) in gastric cancer patients after D2 dissection. METHODS: Between May 2004 and June 2010, patients in our gastric cancer database who underwent D2 dissection for gastric cancer at the First Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. A total of 896 patients were enrolled into this study according to the established inclusion and exclusion criteria. Of these patients, 214 received the XELOX regimen, 48 received FOLFOX6 therapy and 634 patients underwent surgery only without chemotherapy. Overall survival was compared among the three groups using Cox regression and propensity score matchedpair analyses. RESULTS: Patients in the XELOX and FOLFOX6 groups were younger at the time of treatment (median age 55.2 years; 51.2 years vs 58.9 years), had more undifferentiated tumors (70.1%; 70.8% vs 61.4%), and more lymph node metastases (80.8%; 83.3% vs 57.7%), respectively. Overall 5-year survival was 57.3% in the XELOX group which was higher than that (47.5%) in the surgery only group (P = 0.062) and that (34.5%) in the FOLFOX6 group (P = 0.022). Multivariate analysis showed that XELOX therapy was an independent prognostic factor (hazard ratio = 0.564, P < 0.001). After propensity score adjustment, XELOX significantly increased overall 5-year survival compared to surgery only (58.2% vs 44.2%, P = 0.025) but not compared to FOLFOX6 therapy (48.5% vs 42.7%, P = 0.685). The incidence of grade 3/4 adverse reactions was similar between the XELOX and FOLFOX6 groups, and more patients suffered from hand-foot syndrome in the XELOX group (P = 0.018). CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy. | Ying Wu Zhe-Wei Wei Yu-Long He Roderich E Schwarz David D Smith Guang-Kai Xia Chang-Hua Zhang | 2013 | World Journal of Gastroenterology2013，19，21： | 14 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Encapsulated C60 in carbon nanotubes 显示文摘 | Brian W Smith Mare Monthioux David E Luzzi | 1998 | Nature1998，396，： | 1 |
| 4 | endometrial autoantigens eliciting immunoglobulin (Ig)G,IgA and IgM responses in endometriosis显示文摘 | Mathur S David E Smith L | 1990 | Fertility and Sterility1990，54，1： | 1 |
| 5 | Two-Way Laser Link over Interplanetary Distance显示文摘 | David E Smith Maria T Zuber Xiaoli Sun | 2006 | Science(S0036-8075)2006，311，： | 1 |
| 6 | Phytoremediation of metals using plants to remove pollutants from the environment显示文摘 | Iilya Raski Robert D smith and david E Salt | 1997 | J Current Opinion in Biotechnology1997，8，2： | 1 |
| 7 | Genetic optimization using a penatly function显示文摘 | Smith A E David M Tate | 1993 | Proceedings of the Fifth International Conference on Genetic Algorithus1993，，： | 1 |
| 8 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 9 | Phytoremediation of metals: using plants to remove pollutants from the environment显示文摘 | Ilya Raskin Robert D Smith David E Salt | 1997 | Current Opinion in Biotechnology1997，，2： | 1 |
| 10 | Penalty guided genetic search for reliability design optimization显示文摘 | Coit David W Smith Alice E | 1996 | Computers and Industrial Engineering1996，30，4： | 1 |
| 11 | Paint - Only Is Equivalent to Scrub - and - Paint in Preoper-ative Preparationof Abdominal Surgery Sites 显示文摘 | Joshua DI Ellenhom David D Smith Roderich E Schwarz etal | 2005 | J Am CoilSurg2005，201，5： | 1 |
| 12 | Experimental Demonstration of Dynamic High-Speed Equalization of Three WDM Chands Using Acoustooptic Modulators and a Wavelength Demultiplexer 显示文摘 | Cai JinXing Feng Kaiming Chen Xiaopeng Willner Alan E Smith David A Lee ChauHan and Chen YungJui | 1997 | IEEE Photon Technol1997，9，： | 1 |
| 13 | Two-way laser link over interplanetary distance 显示文摘 | Smith David E Zuber Mafia T Sun Xiaoli | 2006 | Science2006，311，： | 1 |
| 14 | Variation in the expression of cell envelope proteins of coagulase-negative staphy- lococci cultured under iron-restricted condi- tions in human peritoneal dialysate 显示文摘 | Mark H Wilcox Paul Williams David G E Smith | 1991 | Journal of Microbiology1991，137，： | 1 |
| 15 | Atmospheric density during the aerobraking of Mars Odyssey from radio tracking data显示文摘 | Mazarico Erwan Zuber Maria T Lemoine Frank G Smith David E | 2007 | Journal of Spacecraft and Rockets2007，44，5： | 1 |
| 16 | Beyond bumouot:when the conselor needs help显示文摘 | Richard B Seymour David E Smith Terry Chambers | 2003 | Journal of Psychoactive Drugs2003，35，3： | 1 |
| 17 | Phytore-mediation of metals: using plants to remove pollutants from the environment 显示文摘 | Raskin IIya Smith Robert D Salt David E | 1997 | Current Opinion in Biotechnology1997，8，2： | 1 |
| 18 | Bleaching of nature fibers with TAED and NOBS activated peroxide systems显示文摘 | JACKIE Y C DAVID J E SHAUN M SMITH | 2001 | AATCC Review2001，，1： | 1 |
| 19 | Community-associated methicillin-resistant Staphylococcus aureus in outpatients, United States, 1999 - 2006显示文摘 | Klein E David L Smith etal | 2009 | Emerg Infect Dis2009，15，12： | 1 |
| 20 | A Low-Power Programmable Bandpass Filter Section for Higher Order Filter Applications 显示文摘 | David W Graham Paul E Hasler Ravi Chawla Paul D Smith | 2007 | IEEE Trans Circuits Syst I2007，54，6： | 1 |
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