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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Placental angiogenesis in sheep models of compromised pregnancy 显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physiology2005，，： | 1 |
| 3 | Placental angiogensis in sheep sodels of compromised pregnancy显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physology2005，565，1： | 1 |
| 4 | Cog nitive outcome after coronary artery bypass: a one-year prospective study显示文摘 | McKhann GM Goldsborough MA Borowicz LM | 1997 | Ann Thorae Surg1997，63，3： | 1 |
| 5 | Angiogenesis in the female reproductive organs:Pathological implications显示文摘 | Borowicz PP Redmer DA | 2002 | Int J Exp Pathol2002，83，4： | 1 |
| 6 | 7-Ni-troindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clowazepam against pentylenetetrazol-induced convulsions 显示文摘 | Borowicz K K Luszczki J Kleinrok Z | 2000 | J Neural Transm2000，107，： | 1 |
| 7 | Determinants of cognitive change after coronary artery bypass surgery : a multifactorial problem 显示文摘 | Seines OA Goldsborough MA Borowicz LM | 1999 | Ann Thorac Surg1999，67，6： | 1 |
| 8 | Neuropsychological change after cardiac surgery:a critical review显示文摘 | Goldsborough MA Selnes OA | 1996 | J Cardiothorac Vasc Anesth1996，10，1： | 1 |
| 9 | Neuroprotective role of testosterone in the nervous system显示文摘 | Bialek M Zaremba P Borowicz KK | 2004 | Pol J Pharmacol2004，56，5： | 1 |
| 10 | Cognitive and neurobehavioral dysfunction after cardiac bypass procedures显示文摘 | Selnes OA McKhann GM Borowicz LM Jr | 2006 | Neurol Clin2006，24，1： | 1 |
| 11 | Influence of melatonin upon the protective action of conventionsl anti-epileptic drugs against maximal electroshock in mice显示文摘 | Kinga K Borowicz RK Maciej G | 1999 | Europ Neuropsychopharmacol1999，9，： | 1 |
| 12 | Uteroplacental vascular development and pla-centalfunction:an update显示文摘 | Reynolds LP Borowicz PP Caton JS | 2010 | Int J Dev Biol2010，54，23： | 1 |
| 13 | Management of biliary strictures due to laparoscopic cholecystectomy 显示文摘 | Borowicz MR Adams DB Cunningham JT | 1995 | J Surg Res1995，58，1： | 1 |
| 14 | Placental development during early pregnancy in sheep:vascular growth and expression of angiogenic factors in maternal placenta 显示文摘 | Grazul-Bilska AT Borowicz PP Johnson ML | 2010 | Reproduction2010，140，1： | 1 |
| 15 | Is there cognitive decline 1 year after CA BG? Comparison with surgical and nonsurgical controls 显示文摘 | McKhann GM Grega MA Borowicz LM | 2005 | Neurology2005，65，5： | 1 |
| 16 | Neurobehavioural sequelae of cardiopulmonary bypass显示文摘 | Selnes OA Goldsborough MA Borowicz LM | 1999 | Lancet1999，353，9164： | 1 |
| 17 | Diagnosis of hymenoptera venom allergy-with special emphasis on honeybee (Apis mellifera) venom allergy显示文摘 | Matysiak J Matysiak J Br?borowicz A | 2013 | Ann Agric Environ Med2013，20，4： | 1 |
| 18 | Prenatal diagnosis of vasa previa显示文摘 | Grzegorz H. Br&eogon borowicz Wies&lstrok aw Markwitz Agata Szpera-Go&zacute dziewicz Anna Dera-Szymanowska Mariola Ropacka-Lesiak Piotr Szyma&nacute ski Beata Kubiaczyk-Paluch | 2014 | The Journal of Maternal-Fetal & Neonatal Medicine2014，，： | 1 |
| 19 | Zonisamide : A new antiepileptic drug显示文摘 | SOBIESZEK G BOROWICZ K K KIMBER-TROJNAR Z | 2003 | Pol J Pharmacol2003，55，： | 1 |
| 20 | Cognitive outcome after coronary artery bypass:a one-year prospective study显示文摘 | McKhann GM Goldsborough MA Borowicz LM | 1997 | Ann Thorac Surg1997，63，2： | 1 |
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