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| 1 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 2 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 3 | A Multi-granularity Decomposition Mechanism of Complex Tasks Based on Density Peaks显示文摘There are many algorithms for solving complex problems in supervised manner. However, unsupervised tasks are more common in real scenarios. Inspired by the idea of granular computing and the characteristics of human cognitive process, this paper proposes a complex tasks decomposition mechanism based on Density Peaks Clustering(DPC) to address complex tasks with an unsupervised process, which simulates the multi-granular observation and analysis of human being. Firstly, the DPC algorithm is modified to nullify its essential defects such as the difficulty of locating correct clustering centers and classifying them accurately. Then, the improved DPC algorithm is used to construct the initial decomposition solving space with multi-granularity theory. We also define subtask centers set and the granulation rules to guide the multi-granularity decomposing procedure. These rules are further used to decompose the solving space from coarse granules to the optimal fine granules with a convergent and automated process. Furthermore, comprehensive experiments are presented to verify the applicability and veracity of our proposed method in community-detection tasks with several benchmark complex social networks.The results show that our method outperforms other four state-of-the-art approaches. | Ziling Pang Guoyin Wang Jie Yang | 2018 | Big Data Mining and Analytics2018，1，3： | 3 |
| 4 | Characterization of a Lacustrine Shale Reservoir and the Evolution of its Nanopores: A Case Study of the Upper Cretaceous Qingshankou Formation in the Songliao Basin, Northeastern China显示文摘The Songliao Basin is one of the most important petroliferous basins in northern China. With a recent gradual decline in conventional oil production in the basin, the exploration and development of unconventional resources are becoming increasingly urgent. The Qingshankou Formation consists of typical Upper Cretaceous continental strata, and represents a promising and practical replacement resource for shale oil in the Songliao Basin. Previous studies have shown that low-mature to mature Qingshankou shale mainly preserves type Ⅰ and type Ⅱ1 organic matter, with relatively high total organic carbon(TOC) content. It is estimated that there is a great potential to explore for shale oil resources in the Qingshankou Formation in this basin. However, not enough systematic research has been conducted on pore characteristics and their main controlling factors in this lacustrine shale reservoir. In this study, 19 Qingshankou shales from two wells drilled in the study area were tested and analyzed for mineral composition, pore distribution and feature evolution using Xray diffraction(XRD), scanning electron microscopy(SEM), low-pressure nitrogen gas adsorption(N2-GA), and thermal simulation experiments. The XRD results show that clay, quartz, and feldspar are the dominant mineral constituents of Qingshankou shale. The clay minerals are mostly illite/smectite mixed layers with a mean content of 83.5%, followed by illite, chlorite, and kaolinite. There are abundant deposits of clay-rich shale in the Qingshankou Formation in the study area, within which many mineral and organic matter pores were observed using SEM. Mineral pores contribute the most to shale porosity;specifically, clay mineral pores and carbonate pores comprise most of the mineral pores in the shale. Among the three types of organic matter pores, type B is more dominant the other two. Pores with diameters greater than 10 nm supply the main pore volume;most are half-open slits and wedge-shaped pores. The total pore volume had no obvious linear relationship with TOC content, but had some degree of positive correlation with the content of quartz + feldspar and clay minerals respectively. However, it was negatively correlated with carbonate mineral content. The specific surface area of the pores is negatively related to TOC content, average pore diameter, and carbonate mineral content. Moreover, it had a somewhat positive correlation with clay mineral content and no clear linear relationship with the content of quartz + feldspar. With increases in maturity, there was also an increase in the number of carbonate mineral dissolution pores and organic matter pores, average pore diameter, and pore volume, whereas there was a decrease in specific surface area of the pores. Generally, the Qingshankou shale is at a low-mature to mature stage with a TOC content of more than 1.0%, and could be as thick as 250 m in the study area. Pores with diameters of more than 10 nm are well-developed in the shale. This research illustrates that there are favorable conditions for shale oil occurrence and enrichment in the Qingshankou shale in the study area. | ZHANG Xu LIU Chenglin LI Bing WU Linqiang GUI Herong WANG Ziling ZHANG Zhihui LIANG Dexiu | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 2 |
| 5 | Flesh quality of hybrid grouper(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)fed with hydrolyzed porcine mucosasupplemented low fishmeal diet显示文摘Iso-nitrogenous and iso-lipidic diets containing 0%,3%,6%,9%,and 12%hydrolyzed porcine mucosa(namely,HPM0,HPM3,HPM6,HPM9,and HPM12)were prepared to evaluate their effects on the growth performance,muscle nutrition composition,texture property,and gene expression related to muscle growth of hybrid groupers(Epinephelus fuscoguttatus\Epinephelus lanceolatus_).Groupers were fed to apparent satiation at 08:00 and 16:00 every day for a total of 56 days.It was found that the weight gain percentage in the HPM0,HPM3,and HPM6 groups did not differ(P>0.05).The cooking loss and drip loss of the dorsal muscle in the HPM3 group were lower than those in the HPM6 and HPM9 groups(P<0.05).The hardness and chewiness of the dorsal muscle in the HPM3 group were higher than those in the HPM0,HPM9,and HPM12 groups(P<0.05).The gumminess in the HPM3 group was higher than that in the HPM9 and HPM12 groups(P<0.05).The total essential amino acid content of the dorsal muscle in the HPM12 group was higher than that in the HPM0 group(P<0.05).The contents of total n-3 polyunsaturated fatty acid and total n-3 highly unsaturated fatty acid,as well as the ratio of n-3/n-6 polyunsaturated fatty acid in the dorsal muscle was higher in the HPM0 group than in all other groups(P<0.05).The relative expressions of gene myogenic factor 5,myocyte enhancer factor 2c,myocyte enhancer factor 2a,myosin heavy chain,transforming growth factor-beta 1(TGF-b1),and follistatin(FST)were the highest in the dorsal muscle of the HPM3 group.The results indicated that the growth performance of hybrid grouper fed a diet with 6%HPM and 27%fish meal was as good as that of the HPM0 group.When fish ingested a diet containing 3%HPM,the expression of genes TGF-β1 and FST involved in muscle growth were upregulated,and then the muscle quality related to hardness and chewiness were improved.An appropriate amount of HPM could be better used in grouper feed. | Xuanyi Yang Xinyan Zhi Ziling Song Guanghui Wang Xumin Zhao Shuyan Chi Beiping Tan | 2022 | Animal Nutrition2022，，1： | 2 |
| 6 | Optimal charging plan for electric bus considering time-of-day electricity tariff显示文摘Purpose–The purpose of this study is to develop an optimization method for charging plans with the implementation of time-of-day(TOD)electricity tariff,to reduce electricity bill.Design/methodology/approach–Two optimization models for charging plans respectively with fixed and stochastic trip travel times are developed,to minimize the electricity costs of daily operation of an electric bus.The charging time is taken as the optimization variable.The TOD electricity tariff is considered,and the energy consumption model is developed based on real operation data.An optimal charging plan provides charging times at bus idle times in operation hours during the whole day(charging time is 0 if the bus is not get charged at idle time)which ensure the regular operation of every trip served by this bus.Findings–The electricity costs of the bus route can be reduced by applying the optimal charging plans.Originality/value–This paper produces a viable option for transit agencies to reduce their operation costs. | Yuhan Liu Linhong Wang Ziling Zeng Yiming Bie | 2022 | Journal of Intelligent and Connected Vehicles2022，5，2： | 1 |
| 7 | Preparation of mesoporous silica films on a glass slide : Surfaetant template removal by solvent extraction 显示文摘 | Hua Zile Shi Jianlin Wang Lin | 2001 | Journal of Non - Crystalline Solids2001，292，13： | 1 |
| 8 | Construction of Case Database for Postgraduate Course Aquatic Animal Pathogen Biology显示文摘As an application instructional course for Aquatic Animal Medicine(AAM),Aquatic Animal Pathogen Biology needs to be guided by a large number of examples and cases,but the current case database construction faces many urgent problems.In view of this,this paper analyzes the characteristics of professional education of AAM postgraduate students.With the goal of cultivating applied personnel that meet the requirements of the times,and the guiding ideology of strengthening the reform of the education model in colleges and universities,and improving the quantity and quality of personnel training,it builds a case database for the course Aquatic Animal Pathogen Biology in accordance with modern postgraduate teaching needs. | Huanying PANG Miao XIE Shuanghu CAI Ziling WANG Shiping YANG Yucong HUANG Jichang JIAN | 2022 | Asian Agricultural Research2022，14，2： | 1 |
| 9 | Evolution process of rock mass engineering system using systems science显示文摘1.Introduction The rock mass engineering system(RMES)basically consists of rock mass engineering(RME),water system and surrounding ecological environments.etc.The RMES is characterized by nonlinearity,occurrence of chaos and self-organization(Tazaka,1998;Tsuda,1998;Kishida,2000).From construction to abandonment of RME,the RMES will experience four stages,i.e.initial phase,development phase,declining phase and failure phase.In | Laigui Wang Yanhui Xi Xiangfeng Liu Na Zhao Ziling Song | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，6： | 1 |
| 10 | Electrocatalysis and determination of hydrazine compounds at glassy carbon electrodes coated with mixed-valent ruthenium(Ⅲ,Ⅱ)cyanide films显示文摘 | Joseph Wang Ziling Lu | 2005 | Electroanalysis2005，，6： | 1 |
| 11 | Perovskite single-pixel detector for dual-color metasurface imaging recognition in complex environment显示文摘Highly efficient multi-dimensional data storage and extraction are two primary ends for the design and fabrication of emerging optical materials.Although metasurfaces show great potential in information storage due to their modulation for different degrees of freedom of light,a compact and efficient detector for relevant multi-dimensional data retrieval is still a challenge,especially in complex environments.Here,we demonstrate a multi-dimensional image storage and retrieval process by using a dual-color metasurface and a double-layer integrated perovskite single-pixel detector(DIP-SPD).Benefitting from the photoelectric response characteristics of the FAPbBr2.4l0.6 and FAPbl3 films and their stacked structure,our filter-free DIP-SPD can accurately reconstruct different colorful images stored in a metasurface within a single-round measurement,even in complex environments with scattering media or strong background noise.Our work not only provides a compact,filter-free,and noise-robust detector for colorful image extraction in a metasurface,but also paves the way for color imaging application of perovskite-like bandgap tunable materials. | Jiahao Xiong Zhi-Hong Zhang Zile Li Peixia Zheng Jiaxin Li Xuan Zhang Zihan Gao Zhipeng Wei Guoxing Zheng Shuang-Peng Wang Hong-Chao Liu | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 12 | Construction of Bilingual Teaching Mode of Aquatic Animal Bacteriology in the Context of the Belt and Road Initiative显示文摘Aquatic Animal Bacteriology is a basic course of Aquatic Animal Medicine discipline.Bacteriology is not only a frontier subject in the field of life sciences,but also one of the most rapidly developing scientific fields today.The Belt and Road Initiative has brought opportunities and challenges to the upgrading and development of this discipline,so this discipline faces many problems that need to be solved.In view of this,this study combined the development trend of the discipline,reorganized and optimized the course content,and prepared sophisticated multimedia courseware,to stimulate students'learning initiative and enthusiasm,expand the field of professional knowledge,improve their English translation and writing skills,so as to lay a solid foundation for their future service to the Belt and Road Initiative. | Huanying PANG Miao XIE Shuanghu CAI Ziling WANG Yucong HUANG Yu HUANG Jichang JIAN | 2022 | Asian Agricultural Research2022，14，2： | 0 |
| 13 | Development of a bias power supply for Geiger mode avalanche photodiodes显示文摘Avalanche photodiodes(APDs)have high output and high stability requirements for bias power in Geiger mode.This paper designs an APD with high boost ratio,high precision,low temperature drift,small size,and low power.Bias power supply,this module uses switching chip IC and flyback transformer to achieve high step-up ratio,realizes precise output control through precision operational amplifier and T-type resistor feedback network,and designs appropriate compensation network to improve system stability.The size of the module is 2.5 cm×2.5 cm,the output voltage is adjustable from 0 to 450 V,and the maximum ripple does not exceed 5.4 mV.By changing the control voltage,any type of APD in Geiger mode can be biased,and the maximum deviation of the bias voltage does not exceed 0.5%. | MENG Yinjie WEI Zhengjun YAN Ziling WANG Jindong | 2023 | Optoelectronics Letters2023，19，11： | 0 |
| 14 | Practice Instruction of Innovative and Entrepreneurial Training Program for Aquatic Animal Medicine Students显示文摘As an important platform for the combination of theory and practice,college students' innovative and entrepreneurial training program has an important impact on improving the comprehensive ability of undergraduates. The major of aquatic animal medicine is a new sea-related major. The continuous development and transformation and upgrading of aquaculture in the new period have put forward newer and higher requirements for the innovative and practical ability and comprehensive quality of aquatic animal medicine graduates. Taking the innovation and entrepreneurship program of college students majoring in aquatic animal medicine as an example,this paper analyzes the significance of the innovation training program for college students,the cultivation of students' scientific research ability,and the problems existing in the application and operation of the program,in order to provide a reference for the innovative education and talent training for students majoring in aquatic animal medicine. | Huanying PANG Miao XIE Ziling WANG Xiuying YAN Huiling LIU Changling LI Jichang JIAN | 2019 | Asian Agricultural Research2019，11，4： | 0 |
| 15 | Cleaner geopolymer prepared by co-activation of gasification coal fly ash and steel slag:durability properties and economic assessment显示文摘Geopolymer is a material with high early strength.However,the insufficient durability properties,such as long-term strength,acid-base resistance,freeze-thaw resistance,leaching toxicity,thermal stability,sulfate resistance and carbonation resistance,restrain its practical application.Herein,a longterm stable geopolymer composite with high final strength(ASK1)was synthesized from shell coal gasification fly ash(SFA)and steel slag(SS).Additionally,a geopolymer composite with high early strength(ASK2)was also synthesized for comparison.The results showed that ASK1 exhibited better performance on freezing-thawing resistance,carbonization resistance and heavy metals stabilization compared to the ASK2 at long-term curing.Raising the curing temperature could accelerate the unconfined compressive strength(UCS)development at initial curing ages of 3 to 7 d.Both ASK1 and ASK2 exhibited excellent acid-base and sulfate corrosion resistance.An increase for UCS was seen under KOH solution and MgSO_(4)solution corrosion for ASK1.All leaching concentrations of heavy metals out of the two geopolymers were below the standard threshold,even after 50 freezingthawing cycles.Both ASK1 and ASK2 geopolymer concrete exhibited higher sustainability and economic efficiency than Portland cement concrete.The result of this study not only provides a suitable way for the utilization of industrial solid waste in civil and environmental engineering,but also opens a new approach to improve the long-term stabilities of the geopolymers. | Xian Zhou Xia Chen Ziling Peng Yongmen Zhou Yan Li Wang Jian Zeyu Fan Yuchi Chen | 2023 | Frontiers of Environmental Science & Engineering2023，17，12： | 0 |
| 16 | Angelica sinensis polysaccharides ameliorate 5-flourouracil-induced bone marrow stromal cell proliferation inhibition via regulating Wnt/β-catenin signaling显示文摘Chemotherapy may cause cellular oxidative stress to bone marrow.Oxidative damage of bone marrow hematopoietic microenvironment is closely related to chronic myelosuppression after chemotherapeutic treatment.Angelica sinensis polysaccharides(ASP)are major effective ingredients of traditional Chinese medicine Angelica with multi-target anti-oxidative stress features.In the current study,we investigated the protective roles and mechanisms of ASP on chemotherapy-induced bone marrow stromal cell(BMSC)damage.The human bone marrow stromal cell line HS-5 cells were divided into control group,5-FU group,5-FU+ASP group,and 5-FU+LiCl group to investigate the mechanism of ASP to alleviate 5-FU-induced BMSC proliferation inhibition.The results showed that 5-FU inhibits the growth of HS-5 cells in a time and dose-dependent manner;however,ASP partially counteracted the 5-FU-induced decrease in cell viability,whereas Wnt signaling inhibitor Dkk1 antagonized the effect of ASP on HS-5 cells.ASP reversed the decrease in total cytoplasmicβ-catenin,p-GSK-3β,and CyclinD1 following 5-FU treatment and modulated nuclear expression ofβ-catenin,Lef-1,and C-myc proteins.Furthermore,ASP also enhanced the antioxidant capacity of cells and reduced 5-FU-induced oxidative stress,attenuated FoxO1 expression,thus weakened its downstream apoptosis-related proteins and G0/G1 checkpoint-associated p27^(Kip1) expression to alleviate 5-FU-induced apoptosis and to promote cell cycle progression.All the results above suggest that the protective role of ASP in 5-FU-treated BMSCs proliferation for the chemotherapy may be related to its activating Wnt/β-catenin signaling and keeping homeostasis betweenβ-catenin and FoxO1 under oxidative stress.The study provides a potential therapeutic strategy for alleviating chemotherapeutic damage on BMSCs. | HANXIANZHI XIAO RONGJIA QI ZILING WANG MINGHE XIAO YUE XIANG YAPING WANG LU WANG | 2021 | BIOCELL2021，45，4： | 0 |
| 17 | Trip energy consumption estimation for electric buses显示文摘This study aims to develop a trip energy consumption(TEC)estimation model for the electric bus(EB)fleet planning,operation,and life-cycle assessment.Leveraging the vast variations of temperature in Jilin Province,China,real-world data of 31 EBs operating in 14 months were collected with temperatures fluctuating from27.0 to 35.0℃.TEC of an EB was divided into two parts,which are the energy required by the traction and battery thermal management system,and the energy required by the air conditioner(AC)system operation,respectively.The former was regressed by a logarithmic linear model with ambient temperature,curb weight,travel distance,and trip travel time as contributing factors.The optimum working temperature and regression parameters were obtained by combining Fibonacci and Weighted Least Square.The latter was estimated by the operation time of the AC system in cooling mode or heating mode.Model evaluation and sensitivity analysis were conducted.The results show that:(i)the mean absolute percentage error(MAPE)of the proposed model is 12.108%;(ii)the estimation accuracy of the model has a probability of 99.7814% meeting the requirements of EB fleet scheduling;(iii)the MAPE has a 1.746% reduction if considering passengers’boarding and alighting. | Jinhua Ji Yiming Bie Ziling Zeng Linhong Wang | 2022 | Communications in Transportation Research2022，2，1： | 0 |
| 18 | Replacing urban trucks via ground-air cooperation显示文摘The advent of drones is leading to a paradigm shift in courier services,while their large-scale deployment is confined by a limited range.Here,we design a low-cost product that allows drones to drop parcels onto and pick them up from the roofs of moving passenger vehicles.With this,we propose a ground-air cooperation(GAC)based business model for parcel delivery in an urban environment.As per our case study using real-world data in Beijing,the new business model will not only shorten the parcel delivery time by 86.5% with a comparable cost,but also reduce road traffic by 8.6%,leading to an annual social benefit of 6.67 billion USD for Beijing.The proposed model utilizes the currently“wasted or unused”rooftops of passenger vehicles and has the potential to replace most parcel trucks and trailers,thus fundamentally addressing the congestion,noise,pollution,and road wear and tear problems caused by trucks,and bringing in immense social benefit. | Xiaobo Qu Ziling Zeng Kai Wang Shuaian Wang | 2022 | Communications in Transportation Research2022，2，1： | 0 |
| 19 | Study on the thermal decomposition characteristics of C_(4)F_(7)N-CO_(2)mixture as ecofriendly gas-insulating medium显示文摘The authors explored the thermal decomposition characteristics of perfluoroisobutyronitrile–carbon dioxide(C_(4)F_(7)N–CO_(2))gas mixture as eco-friendly dielectric medium.The main by-products and decomposition mechanism of C_(4)F_(7)N–CO_(2)gas mixture under different temperature and gas pressure conditions were revealed and analysed.It was found that the thermal decomposition of 6%C_(4)F_(7)N–94%CO_(2)gas mixture starts at about 350°C(0.15 MPa),producing C_(3)F_(6) and CO first.Some other characteristic by-products such as CF_(4),C_(2)F_(6),CF_(3)CN,COF_(2) and(CN)_(2) could also be detected at higher temperature.The yield of C_(3)F_(6),(CN)_(2) increased with the temperature(lower than 450℃)first and then decreased when it reached to 500℃.While the yield of CO,C3F8,COF_(2) and CF_(3)CN increased with temperature(350–550℃).The generation of CF_(4) and C_(2)F_(6) begins at temperatures higher than 500℃,which can be used as the feature component of severe overheating fault.The thermal decomposition amount and by-products yield of C_(4)F_(7)N–CO_(2)gas mixture slowed down with the increase of gas pressure,indicating that C_(4)F_(7)N–CO_(2)gas mixture is quite suitable used at high-pressure equipment,especially high-voltage devices such as gas insulated switchgear. | Yi Li Xiaoxing Zhang Ji Zhang Cheng Xie Xianjun Shao Ziling Wang Dachang Chen Song Xiao | 2020 | High Voltage2020，5，1： | 0 |
| 20 | Study on the relationship of iodine nutritional status with thyroid function and autoantibodies in pregnant women in Baotou显示文摘Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine supplementation.Methods:By use of As-Ce catalysis spectrophotometry,the urinary iodine concentration was determined in 90 women during different periods of pregnancy admitted to Baogang Hospital of Inner Mongolia from January 2017 to December 2017.The determination of thyroid function and the autoantibody level was carried out by electro-chemiluminescence immunoassay(ECLIA).Results:In the early trimester of pregnancy,pregnant women with iodine deficiency,iodine sufficiency and iodine excess accounted for 36.67%,40.00%and 23.33%respectively;in the middle trimester of pregnancy,they accounted for 66.67%,26.67%and 6.66%respectively;they made up 40.00%,40.00%and 20.00%respectively in the late trimester of pregnancy.The rate of iodine deficiency in women in the middle trimester of pregnancy was significantly higher than that in women in the early and the late trimesters of pregnancy respectively,and the difference was statistically significant(p<0.05).The rate of iodine deficiency in pregnant women was positively correlated to the positivity of thyroid peroxidase antibody.Moreover,it had no relationship with the positivity of thyroglobulin antibody.No matter in the pregnant women with iodine deficiency or with iodine excess,the abnormality rate of thyroid function and autoantibodies was significantly higher than that in the pregnant women with iodine sufficiency.The difference was statistically significant(p<0.05).Conclusions:The iodine deficiency in the women in the middle trimester of pregnancy is more severe than that in the women in the early and the late trimesters of pregnancy.Iodine deficiency during pregnancy is positively correlated with the positivity of thyroid peroxidase antibody.Pregnant women with iodine deficiency and iodine excess show a higher abnormality rate of thyroid function and autoantibodies.It is recommended to advocate health education on iodine nutrition to pregnant women,and conduct the dynamic monitoring of urinary iodine concentration and the screening of thyroid function and autoantibodies during pregnancy. | Yuanyuan Fan Yalu Wang Chenhui Li Ziling Li | 2020 | Discussion of Clinical Cases2020，7，1： | 0 |
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