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| 1 | Spatial modulation of nanopattern dimensions by combining interference lithography and grayscale-patterned secondary exposure显示文摘Functional nanostructures are exploited for a variety of cutting-edge fields including plasmonics,metasurfaces,and biosensors,just to name a few.Some applications require nanostructures with uniform feature sizes while others rely on spatially varying morphologies.However,fine manipulation of the feature size over a large area remains a substantial challenge because mainstream approaches to precise nanopatterning are based on low-throughput pixel-by-pixel processing,such as those utilizing focused beams of photons,electrons,or ions.In this work,we provide a solution toward wafer-scale,arbitrary modulation of feature size distribution by introducing a lithographic portfolio combining interference lithography(IL)and grayscale-patterned secondary exposure(SE).Employed after the high-throughput IL,a SE with patterned intensity distribution spatially modulates the dimensions of photoresist nanostructures.Based on this approach,we successfully fabricated 4-inch wafer-scale nanogratings with uniform linewidths of<5%variation,using grayscale-patterned SE to compensate for the linewidth difference caused by the Gaussian distribution of the laser beams in the IL.Besides,we also demonstrated a wafer-scale structural color painting by spatially modulating the filling ratio to achieve gradient grayscale color using SE. | Zhuofei Gan Hongtao Feng Liyang Chen Siyi Min Chuwei Liang Menghong Xu Zijie Jiang Zhao Sun Chuying Sun Dehu Cui Wen-Di Li | 2022 | Light(Science & Applications)2022，11，5： | 3 |
| 2 | Tumor pyruvate kinase M2:A promising molecular target of gastrointestinal cancer显示文摘Gastrointestinal(GI) cancer is one of the most common causes of cancer-related deaths worldwide.Tumor markers are valuable in detecting post-surgical recurrence or in monitoring response to chemotherapy.Pyruvate kinase isoform M2(PKM2),a glycolytic enzyme catalyzing conversion of phosphoenolpyruvate(PEP) to pyruvate,confers a growth advantage to the tumor cells and enables them to adapt to the tumor microenvironment.In this review,we have summarized current research on the expression and regulation of PKM2 in tumor cells,and its potential role in GI carcinogenesis and progression.Furthermore,we have also discussed the potential of PKM2 as a diagnostic and screening marker,and a therapeutic target in GI cancer. | Chen Guo Guan Li Jianing Hou Xingming Deng Sheng Ao Zhuofei Li Guoqing Lyu | 2018 | Chinese Journal of Cancer Research2018，30，6： | 2 |
| 3 | Prognostic significance of periostin in colorectal cancer显示文摘Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation,fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer(CRC)via activating PI3 K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC. | Xingming Deng Sheng Ao Jianing Hou Zhuofei Li Yunpeng Lei Guoqing Lyu | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 4 | Analysis on Actinobacillus pleuropneumoniae LuxS regulated genes reveals pleiotropic roles of LuxS/AI-2 on biofilm formation, adhesion ability and iron metabolism显示文摘 | Lu Li Zhuofei Xu Yang Zhou Tingting Li Lili Sun Huanchun Chen Rui Zhou | 2011 | Microbial Pathogenesis2011，，6： | 1 |
| 5 | Signal control optimization for automated vehicles at isolated signalized intersections显示文摘 | Li Zhuofei Lily Elefteriadou Sanjay Ranka | 2014 | Transportation Research Part C:Emerging Technologies2014，49，： | 1 |
| 6 | High-fidelity and clean nanotransfer lithography using structure-embedded and electrostatic-adhesive carriers显示文摘Metallic nanostructures are becoming increasingly important for both fundamental research and practical devices.Many emerging applications employing metallic nanostructures often involve unconventional substrates that are flexible or nonplanar,making direct lithographic fabrication very difficult.An alternative approach is to transfer prefabricated structures from a conventional substrate;however,it is still challenging to maintain high fidelity and a high yield in the transfer process.In this paper,we propose a high-fidelity,clean nanotransfer lithography method that addresses the above challenges by employing a polyvinyl acetate(PVA)film as the transferring carrier and promoting electrostatic adhesion through triboelectric charging.The PVA film embeds the transferred metallic nanostructures and maintains their spacing with a remarkably low variation of<1%.When separating the PVA film from the donor substrate,electrostatic charges are generated due to triboelectric charging and facilitate adhesion to the receiver substrate,resulting in a high large-area transfer yield of up to 99.93%.We successfully transferred the metallic structures of a variety of materials(Au,Cu,Pd,etc.)with different geometries with a<50-nm spacing,high aspect ratio(>2),and complex 3D structures.Moreover,the thin and flexible carrier film enables transfer on highly curved surfaces,such as a single-mode optical fiber with a curvature radius of 62.5μm.With this strategy,we demonstrate the transfer of metallic nanostructures for a compact spectrometer with Cu nanogratings transferred on a convex lens and for surface-enhanced Raman spectroscopy(SERS)characterization on graphene with reliable responsiveness. | Zhuofei Gan Jingxuan Cai Zhao Sun Liyang Chen Chuying Sun Junyi Yu Zeyu Liang Siyi Min Fei Han Yu Liu Xing Cheng Shuhui Yu Dehu Cui Wen-Di Li | 2023 | Microsystems & Nanoengineering2023，9，1： | 1 |
| 7 | Gemcitabine Compared With Gemcitabine and S-1 Combination Therapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis显示文摘 | Doudou Li Changhao Chen Yu Zhou Rufu Chen Xinxiang Fan Zhuofei Bi Zhihua Li Yimin Liu | 2015 | Medicine2015，，35： | 1 |
| 8 | Potential of secondary aerosol formation from Chinese gasoline engine exhaust显示文摘Light-duty gasoline vehicles have drawn public attention in China due to their significant primary emissions of particulate matter and volatile organic compounds(VOCs). However,little information on secondary aerosol formation from exhaust for Chinese vehicles and fuel conditions is available. In this study, chamber experiments were conducted to quantify the potential of secondary aerosol formation from the exhaust of a port fuel injection gasoline engine. The engine and fuel used are common in the Chinese market, and the fuel satisfies the China V gasoline fuel standard. Substantial secondary aerosol formation was observed during a 4–5 hr simulation, which was estimated to represent more than 10 days of equivalent atmospheric photo-oxidation in Beijing. As a consequence, the extreme case secondary organic aerosol(SOA) production was 426 ± 85 mg/kg-fuel, with high levels of precursors and OH exposure. The low hygroscopicity of the aerosols formed inside the chamber suggests that SOA was the dominant chemical composition. Fourteen percent of SOA measured in the chamber experiments could be explained through the oxidation of speciated single-ring aromatics. Unspeciated precursors, such as intermediate-volatility organic compounds and semi-volatile organic compounds, might be significant for SOA formation from gasoline VOCs. We concluded that reductions of emissions of aerosol precursor gases from vehicles are essential to mediate pollution in China. | Zhuofei Du Min Hu Jianfei Peng Song Guo Rong Zheng Jing Zheng Dongjie Shang Yanhong Qin He Niu Mengren Li Yudong Yang Sihua Lu Yusheng Wu Min Shao Shijin Shuai | 2018 | Journal of Environmental Sciences2018，30，4： | 0 |
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