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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | Pyrolysis and co-pyrolysis of lignite and plastic显示文摘The study firstly discusses the pyrolysis characteristics and kinetics by thermogravimetric analysis(TGA),and then investigates the pyrolysis of lignite and co-pyrolysis with plastic(polyethylene or polypropylene)in tube furnace.Meanwhile,the research focuses on the co-pyrolysis products under different mixing ratios as well as pyrolysis products at different testing temperatures and heating rates.The results show that higher final testing temperature and lower heating rate contribute to bond fission in lignite pyrolysis,resulting in less char product.In co-pyrolysis,lignite acts as hydrogen donor,and the yields of char and water rise with increasing amount of plastic in the mixture,while the yields of gas and tar decrease;and a little admixture of plastic will promote the production of gas and tar.Kinetic studies indicate that in temperature range of 530–600°C,activation energies of lignite are higher than those of lignite/plastic blends,and as plastic mass ratio increases from 0%to 10%,samples need less energy to be decomposed during co-pyrolysis. | Qian Chunmei Zhou Min Wei Jianghong Ye Puhai Yang Xu | 2014 | International Journal of Mining Science and Technology2014，24，1： | 4 |
| 3 | First-principles study of lithium intercalated bilayer graphene显示文摘Lithium intercalated bilayer graphene has been investigated using first-principles density functional theory calculations. Results show that there exist AB and AA stacking sequences for bilayer graphene in which the latter is more favorable for the Li storage and the former will evolve into the latter with the intercalation of Li ions. The relationship between the interlayer distance of two graphene sheets and the intercalated capacity of Li ions is discussed. It is found that structural defect is identified to store Li ions more favorably than pristine bilayer graphene and an isolated C atom vacancy in bilayer graphene can capture three Li ions between two graphene sheets. | ZHOU JingJing ZHOU WeiWei GUAN ChunMei SHEN JingQin OUYANG ChuYing LEI MinSheng SHI SiQi TANG WeiHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 4 |
| 4 | Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy显示文摘Mounting evidence has revealed that the therapeutic efficacy of immunotherapies is restricted to a small portion of cancer patients.A deeper understanding of how metabolic reprogramming in the tumor microenvironment(TME)regulates immunity remains a major challenge to tumor eradication.It has been suggested that metabolic reprogramming in the TME may affect metabolism in immune cells and subsequently suppress immune function.Tumor cells compete with infiltrating immune cells for nutrients and metabolites.Notably,the immunosuppressive TME is characterized by catabolic and anabolic processes that are critical for immune cell function,and elevated inhibitory signals may favor cancer immune evasion.The major energy sources that supply different immune cell subtypes also undergo reprogramming.We herein summarize the metabolic remodeling in tumor cells and different immune cell subtypes and the latest advances underlying the use of metabolic checkpoints in antitumor immunotherapies.In this context,targeting both tumor and immune cell metabolic reprogramming may enhance therapeutic efficacy. | Chunmei Fan Shanshan Zhang Zhaojian Gong Xiayu Li Bo Xiang Hao Deng Ming Zhou Guiyuan Li Yong Li Wei Xiong Zhaoyang Zeng Xiaoling Li | 2021 | Science China(Life Sciences)2021，64，4： | 4 |
| 5 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 6 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 7 | Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection显示文摘Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. To investigate whether this outbreak of HAdV was related to nosocomial infections or the result of community infections, we collected respiratory specimens from patients with acute respiratory infections in a respiratory ward during June to December 2018, and screened for respiratory viruses. Among 1,840 cases included, 95(5.2%, 95/1840) were positive for HAdV and 81 were genotyped based on phylogenetic analysis, including seven as HAdV-1(8.6%), 30 HAdV-3(37.0%), two HAdV-6(2.5%), and 42 HAdV-7(51.9%). More HAdV-positive samples were collected in August(4.7%, 12/255), September(15.0%, 41/274) and October(6.9%, 17/247), with a peak in September 2018. By combining the results of HAdV phylogenetic analysis with clinical data of patients, there were 77 cases(4.2%, 77/1840;81.1%, 77/95) excluded from nosocomial infections, eight cases representing possible infections transmitted by visitors or attending parents, three cases without sequences that might have been due to infection transmitted by roommates positive for HAdV, one case of a roommate without an HAdV sequence, and six cases that shared highly homologous sequences with those of their roommates, for which nosocomial infections might be considered. In conclusion, genotyping of HAdVs based on phylogenetic analysis combined with clinical information provides a powerful method to distinguish nosocomial infections from community acquired infection, especially when tracing the origins of nosocomial infections. | Chuanyu Yang Chunmei Zhu Yuan Qian Jie Deng Baoyuan Zhang Runan Zhu Fang Wang Yu Sun Dongmei Chen Qi Guo Yutong Zhou Lei Yu Ling Cao Linqing Zhao | 2021 | Virologica Sinica2021，36，3： | 3 |
| 8 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 9 | A multi-functional polymer coating that is heat-resistant,hydrophobic and transparent显示文摘A multi-functional polymer film with high hydrophobicity and transparency was formed by simple casting of a polycarbonate solution onto a substrate having micro-scale roughness.The high hydrophobicity was heat-resistant,which can be retained up to 390 ℃.The polymer film may have potentially wide-ranging applications in industry and high technology. | Tianyi Zhao Dongmei Zhang Chunmei Ding Jinglun Zhou Jinsong Zhu Lei Jiang | 2014 | Particuology2014，12，6： | 2 |
| 10 | Object tracking using SIFT features and mean shift显示文摘 | Huiyu Zhou Yuan Yuan Chunmei Shi | 2008 | Computer Vision and Image Understanding2008，，： | 2 |
| 11 | Identification and Analysis of Human Sex-biased MicroRNAs显示文摘Sex differences are widely observed under various circumstances ranging from physiological processes to therapeutic responses, and a myriad of sex-biased genes have been identified. In recent years, transcriptomic datasets of microRNAs(miRNAs), an important class of non-coding RNAs, become increasingly accessible. However, comprehensive analysis of sex difference in miRNA expression has not been performed. Here, we identified the differentially-expressed miRNAs between males and females by examining the transcriptomic datasets available in public databases and conducted a systemic analysis of their biological characteristics. Consequently, we identified 73 female-biased miRNAs(FmiRs) and 163 male-biased miRNAs(MmiRs) across four tissues including brain, colorectal mucosa, peripheral blood, and cord blood. Our results suggest that compared to FmiRs, MmiRs tend to be clustered in the human genome and exhibit higher evolutionary rate, higher expression tissue specificity, and lower disease spectrum width. In addition,functional enrichment analysis of miRNAs show that FmiR genes are significantly associated with metabolism process and cell cycle process, whereas MmiR genes tend to be enriched for functions like histone modification and circadian rhythm. In all, the identification and analysis of sex-biased miRNAs together could provide new insights into the biological differences between females and males and facilitate the exploration of sex-biased disease susceptibility and therapy. | Chunmei Cui Weili Yang Jiangcheng Shi Yong Zhou Jichun Yang Qinghua Cui Yuan Zhou | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 1 |
| 12 | Object tracking using SIFT features and mean shift显示文摘 | Huiyu Zhou Yuan Yuan Chunmei Shi | 2009 | Computer Vision and Image Understanding2009，113，： | 1 |
| 13 | ?251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case–control studies显示文摘 | Na Wang Rongmiao Zhou Chunmei Wang Xiaoqing Guo Zhifeng Chen Shan Yang Yan Li | 2012 | Molecular Biology Reports2012，，3： | 1 |
| 14 | Object tracking using SIFT features and mean shift显示文摘 | Zhou Huiyu Yuan Yuan Shi Chunmei | 2009 | Computer Vision and Image Understanding2009，113，3： | 1 |
| 15 | Object tracking using SIFT features and mean shiff显示文摘 | Zhou Huiyu Yuan Yuan Shi Chunmei | 2008 | Computer Vision and Image Understanding2008，1133，： | 1 |
| 16 | Frequency reliability sensitivity for dynamic structural systems显示文摘 | ZHANG Yimin LU Chunmei ZHOU Na | | 0，，01： | 1 |
| 17 | Molecular genetic analysis of phosphomannomutase genes in Triticum monococcum显示文摘In higher plants, phosphomannomutase(PMM) is essential for synthesizing the antioxidant ascorbic acid through the Smirnoff–Wheeler pathway. Previously, we characterized six PMM genes(Ta PMM-A1, A2, B1, B2, D1 and D2) in common wheat(Triticum aestivum, AABBDD).Here, we report a molecular genetic analysis of PMM genes in Triticum monococcum(AmAm), a diploid wheat species whose Amgenome is closely related to the A genome of common wheat. Two distinct PMM genes, Tm PMM-1 and Tm PMM-2, were found in T. monococcum. The coding region of Tm PMM-1 was intact and highly conserved. In contrast, two main Tm PMM-2 alleles were identified, with Tm PMM-2a possessing an intact coding sequence and Tm PMM-2b being a pseudogene. The transcript level of Tm PMM-2a was much higher than that of Tm PMM-2b, and a bacterially expressed Tm PMM-2a recombinant protein displayed relatively high PMM activity. In general, the total transcript level of PMM was substantially higher in accessions carrying Tm PMM-1 and Tm PMM-2a than those harboring Tm PMM-1 and Tm PMM-2b. However, total PMM protein and activity levels did not differ drastically between the two genotypes. This work provides new information on PMM genes in T. monococcum and expands our understanding on Triticeae PMM genes, which may aid further functional and applied studies of PMM in crop plants. | Chunmei Yu Xinyan Liu Qian Zhang Xinyu He Wan Huai Baohua Wang Yunying Cao Rong Zhou | 2015 | The Crop Journal2015，3，1： | 1 |
| 18 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 19 | Petrogenesis of the Early Cretaceous Laojunshan monzogranite at the southern margin of the North China Craton: Constrains on the transition of the tectonic regime显示文摘1 Introduction Voluminous Mesozoic magmatic rocks containing abundant Au-Mo polymetallic mineralization resources are developed in the Xiaoqinling-Xiong’ershan district of the southern margin of the North China Craton(NCC). | CAO Leitao TANG Huayun ZHENG Jianping REN Hongwei YU Chunmei XU Zhou HE Shuai | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 20 | Research on Causality Relationship of Low-Carbon Development and Industrial Structure显示文摘 | Liu Chunmei Duan Maosheng Zhang Xiliang Zhou Jieting Zhang Tianhou Yang Guang Ou Xunmin Wang Enchuang Dai Chunyan Guo Shiyi Hu Guangping Zhou Lingling Qi Tianyu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
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