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| 1 | A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China显示文摘Objective: The inhibition of the neovascularization in tumors is a potential therapeutic target of cancer. Vascular endothelial growth inhibitor(VEGI) is a member of the TNF superfamily which has the ability to suppress the formation of new vessels in tumors. In order to study the association between VEGI gene polymorphisms and breast cancer risk, a case-control study was conducted in Chinese Han women in Northeast China.Methods: Our study involved 708 female breast cancer patients and 685 healthy volunteers. Four SNPs of VEGI gene were analyzed through the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. The association between VEGI gene polymorphisms and breast cancer risk was analyzed in our study. The relation between VEGI gene variants and clinical features of breast cancer including lymph node(LN) metastasis, estrogen receptor(ER), progestrogen receptor(PR), tumor protein 53(p53), human epidermal growth factor receptor 2(Her-2) and triple negative(ER-/PR-/Her-2-) status was analyzed as well.Results: We found that the CT genotype and T allele of rs6478106 were more frequent in patients than in controls. There was also a statistical difference in the distribution of C_(rs6478106)G_(rs4263839) haplotype between patients and controls. In addition, SNP rs6478106 and rs4979462 were related with the Her-2 status.Conclusions: Our results suggest that VEGI gene variants may be related to the breast cancer risk and the clinical features of breast cancer in Chinese Han women in Northeast China. | Shaoli Han Lei Liu Fengyan Xu Shuang Chen Weiguang Yuan Zhenkun Fu Dalin Li Dianjun Li | 2016 | Chinese Journal of Cancer Research2016，28，4： | 7 |
| 2 | The relationship between physicochemical characterization and the potential toxicity of fine particulates (PM 2.5 ) in Shanghai atmosphere显示文摘 | Lu Senlin Yao Zhenkun Chen Xiaohui Wu Minghong Sheng Guoying Fu Jiamo Daly Paul | 2008 | Atmospheric Environment2008，，31： | 1 |
| 3 | Peak-Shaving of the Oxy-Fuel Power Plant Coupled with Liquid O_(2)Storage显示文摘Integrating a high proportion of intermittent renewable energy provides a solution for the higher peak-shaving capacity of coal-fired power plants.Oxy-fuel combustion is one of the most promising carbon reduction technologies for coal-fired power plants.This study has proposed a novel oxy-fuel power plant that is coupled with both liquid O_(2)storage and cold energy recovery systems in order to adapt to the peak-shaving requirements.The liquid O_(2)storage system uses cheap valley electricity to produce liquid O_(2)for a later use in the peak period to enhance the peak-shaving capacity.Meanwhile,the cold energy recovery system has been introduced to recover the physical latent energy during the phase change of liquid O_(2)to increase the power generation in the peak period.Technical economies of three power plants,i.e.a 330 MW(e)oxy-fuel power plant as reference(Case 1),the same power plant coupled with only liquid O_(2)storage system(Case 2),and the same power plant coupled with both liquid O_(2)storage and cold energy recovery systems(Case 3),have been analyzed and compared.Thermodynamic performance analysis indicates that the peaking capacity of Case 3 can reach the range of 106.03 to 294.22 MW(e),and the maximum peak-shaving coefficient can be as high as 2.77.Exergy analysis demonstrates that the gross exergy efficiency of Cases 2 and 3 reaches 32.18%and 33.57%,respectively,in the peak period,which are significantly higher than that of 26.70%in Case 1.Economic analysis shows that through selling the liquid O_(2)and liquid CO_(2),combined with carbon trading,the levelized cost of electricity(LCOE)of the three cases have been greatly reduced,with the lowest one of 30.90 USD/MWh shown in Case 3.For a comprehensive consideration,Case 3 can be considered a future reference of oxy-fuel power plant with the best thermodynamic and economic performance. | FU Xuchen WU Jianwen SUN Zhenkun DUAN Yuanqiang GAO Zhengping DUAN Lunbo | 2023 | Journal of Thermal Science2023，32，5： | 0 |
| 4 | Histone Deacetylation Modifier Induced One New Resorcylic Acid Lactone 7′(Z)-zeaenol from the Zoanthid-Derived Fungus Cochliobolus lunatus显示文摘Chemical epigenetic manipulation was applied to the zoanthid-derived fungus Cochliobolus lunatus(TA26-46)with a histone deacetylation modifier(100μmol L^(−1) nicotinamide),resulting in the isolation of a new 14-membered resorcylic acid lactone named 7′(Z)-zeaenol(1),together with six known analogues(2−7)from the treated broth.The planar structure of 1 was determined by comprehensive NMR spectroscopy and HRESIMS data.The absolute configuration of 1 was elucidated by ECD spectrum,^(13)C NMR shift calculations,and on the basis of biogenetic considerations.Compound 5 exhibited cytotoxic activity against the human tumor cell lines A549,HCT-116,HT-29,Hela,MCF-7,and K562 with the IC_(50) values ranging from 2.54 to 7.44μmolL^(−1). | ZHANG Zhenkun WANG Jiaxiang CAO Fei ZHOU Xiaojian WU Jingshuai FU Xiumei CHEN Min WANG Changyun | 2023 | Journal of Ocean University of China2023，22，1： | 0 |
| 5 | Small protein Cgl2215 enhances phenolic tolerance by promoting MytA activity in Corynebacterium glutamicum显示文摘Corynebacterium glutamicum is a promising chassis microorganism for the bioconversion of lignocellulosic biomass owing to its good tolerance and degradation of the inhibitors generated in lignocellulosic pretreatments.Among the identified proteins encoded by genes within the C.glutamicum genome,nearly 400 are still functionally unknown.Based on previous transcriptome analysis,we found that the hypothetical protein gene cgl2215 was highly upregu-lated in response to phenol,ferulic acid,and vanillin stress.The cgl2215 deletion mutant was shown to be more sensitive than the parental strain to phenolic compounds as well as other environmental factors such as heat,ethanol,and oxidative stresses.Cgl2215 interacts with C.glutamicum mycoloyltransferase A(MytA)and enhances its in vitro esterase activity.Sensitivity assays of theΔmytA andΔcgl2215ΔmytA mutants in response to phenolic stress estab-lished that the role of Cgl2215 in phenolic tolerance was mediated by MytA.Furthermore,transmission electron microscopy(TEM)results showed that cgl2215 and mytA deletion both led to defects in the cell envelope structure of C.glutamicum,especially in the outer layer(OL)and electron-transparent layer(ETL).Collectively,these results indicate that Cgl2215 can enhance MytA activity and affect the cell envelope structure by directly interacting with MytA,thus playing an important role in resisting phenolic and other environmental stresses. | Huawei Gu Xinwei Hao Ruirui Liu Zhenkun Shi Zehua Zhao Fu Chen Wenqiang Wang Yao Wang Xihui Shen | 2022 | Stress Biology2022，2，1： | 0 |
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