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| 1 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 2 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 3 | Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue,and its possible role in tumor immunity显示文摘AIM:To investigate the expression of 4-1BB molecule in hepatocellular carcinoma (HCC) and its adjacent tissues.METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the gene expression of 4-1BB in hepatocarcinoma and its adjacent tissues,and peripheral blood mononuclear cells (PBMCs) from both HCC and health control groups.Flow cytometry was used to analyse the phenotypes of T cell subsets from the blood of HCC patients and healthy volunteers,and further to determine whether 4-1BB molecules were also expressed on the surface of CD4+ and CD8+ T cells. The localization of 4-1BB proteins on tumor infiltrating T cells was determined by direct immunofluorescence cytochemical staining and detected by confocal microscopy.RESULTS:4-1BB mRNA, which was not detectable in normal liver,was found in 19 liver tissues adjacent to tumor edge(<1.0cm).Low expression of 4-1BB mRNA was shown in 8 tumor tissues and 6 liver tissues located within 1 to 5cm away from tumor edge. In PBMCs, 4-1BB mRNA was almost not detected. Percentage of CD4^+, CD8^+ and CD3^+/CD25^+ T cells, as well as ratio of CD4 to CD8 revealed no difference between groups (P>0.05,respectively),while a significant lower percentage of CD3^+ T cell was found in HCC group as compared to healthy control group (P<0.05).However, 4-1BB molecules were almost not found on the surface of CD4+ and CD8+ T cells in HCC and healthy control group.Double-staining of 4-1BB^+/CD4^+ and 4-1BB^+/CD8^+ immunofluorescence on tumor infiltrating T cells was detected in 13 liver tissues adjacent to tumor edge (<1.0cm) by confocal microscopy.CONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface,tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment. The present study also implicates that modulating 4-1BB/4-1BBL costimulatory pathway may be an effective immunotherapy strategy to augment the host response. | Wan, YL Zheng, SS Zhao, ZC Li, MW Jia, CK Zhang, H | 2004 | World Journal of Gastroenterology2004，10，2： | 6 |
| 4 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 5 | Effects of Zr on Microstructure and Short-TermStrength in GH586显示文摘0.020, 0.045 and 0.075 wt pct Zr were added to a Ni-base superalloy GH586 to investigate theirefFects on the microstructure and the short-term strengths at 850℃. The results showed thatproper Zr addition could improve the alloy tensile strength at 850℃ and short-term rupture life at850℃, 580 MPa. Zr exists in both γ’ phase and γ matrix, which caused Zr to distribute in graininstead of segregating in grain boundaries, therefore increased both of their lattice parametersbut decreased the mismatch between them. Meanwhile, it also increased the amount of grain-boundary carbides and decreased their size markedly. These contributed to the improvement ofshort-term rupture life. However, further addition of Zr resulted in forming Zr4C2S2, a plate-fike stable sulphurocarbides in grain boundaries, which decreased short-term strength at hightemperature, and led to a worse hot workability. According to the experimental results, theoptimum content of Zr should be 0.020 wt pct. | Xie, SS Wang, TL Lu, JY Yang, HC Zhao, GP | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 6 | An Aqueous Extract ofYunnan Baiyao Inhibits the Quorum-Sensing-Related Viru-lence of Pseudomonas aeruginosa显示文摘 | ZHAO ZG YAN SS YU YM | 2013 | J Microbiol2013，51，2： | 1 |
| 7 | An analysis of fac tots associated with failure of tendon repair in the canine model显示文摘 | Zhao C Moran SL Cha SS | 2007 | J Hand Surg Am2007，32，4： | 1 |
| 8 | Determination of polybrominated diphenyl ethers in human semen 显示文摘 | Liu PY Zhao YX Zhu YY Qin ZF Ruan XL Zhang YC Chen B J Li Y Yan SS Qin XF Fu S Xu XB | 2012 | Environ Int2012，，42： | 1 |
| 9 | Qualitative and quantitative analysis of mierobial transformation of steroidal saponins in Dioseorea zingiberensis 显示文摘 | Qi SS Dong YS Zhao YK | 2009 | Chromatographia2009，69，9： | 1 |
| 10 | Inverse Correlation between CD4+CD25highCD127low/- Regulatory T-cells and Serum Immunoglobulin A in Patients with New-onset Ankylosing Spondylitis显示文摘 | Zhao SS Hu JW Wang J | 2011 | J Int Med Res2011，39，5： | 1 |
| 11 | Temporal and spatial characteristics of apoptosis in the infarcted rat heart显示文摘 | Zhao W Lu L Chen SS Sun Y | 2004 | Biochem Biophys Res Commun2004，325，2： | 1 |
| 12 | Rapid genera- tion of a mouse model for middle east respiratory syn- drome显示文摘 | Zhao J L K Wohlford-Lenane C Agnihothram SS Fett C Zhao J Gale MJ Jr Baric RS Enjuanes L Gallagher T MeCray PB Jr Perlman S | 2014 | ProcNatlAcadSciUSA2014，111，13： | 1 |
| 13 | ROS-Ca2 + is associated withmitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis 显示文摘 | Cao XH Zhao SS Liu DY | 2011 | Chem Biol Interact2011，190，1： | 1 |
| 14 | Idl, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance 显示文摘 | Perry SS Zhao Y Nie L | 2007 | Blood2007，110，7： | 1 |
| 15 | Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nan- oparticles for muhimodality treatment of cancer显示文摘 | MI Y ZHAO J FENG SS | 2013 | J Control Re- lease2013，169，3： | 1 |
| 16 | Neuroprotective effect of 4-hydroxybenzyl alcohol against transient fecal cerebral ischemia via antiapoptosis in rats显示文摘 | Yu SS Zhao J Zheng WP | | 0，，： | 1 |
| 17 | A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies显示文摘 | Zhao LP Li SS Khalid N | 2003 | Am J Hum Genet2003，72，： | 1 |
| 18 | Temporal and spatial characteristics of apoptosis in the infarcted rat heart 显示文摘 | Zhao W Lu L Chen SS | 2004 | Biochem Biophys Res Commun2004，325，2： | 1 |
| 19 | Functional comparison of the Hoxa4,Hoxa10,and Hoxa 11 homeoboxes显示文摘 | Potter SS | 2002 | Dev Biol2002，244，1： | 1 |
| 20 | Superior removal of hydantoin lesions relative to other oxidized bases by the hu-man DNA gtycosylase hNEILl显示文摘 | Krishnamurthy N Zhao X Burrows C J David SS | 2008 | Biochemistry2008，47，27： | 1 |
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