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| 1 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 2 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 3 | An Aqueous Extract ofYunnan Baiyao Inhibits the Quorum-Sensing-Related Viru-lence of Pseudomonas aeruginosa显示文摘 | ZHAO ZG YAN SS YU YM | 2013 | J Microbiol2013，51，2： | 1 |
| 4 | Mitochondrial permeability transition pore is a potential drug target for neurodegeneration显示文摘 | Rao VK Carlson EA Yan SS | 2013 | Biochimica et Biophysica Acta(BBA)-Molecular Basis of Disease2013，，： | 1 |
| 5 | Mitochondrial permeability transition pore in Alzheimer’s disease:cyclophilin D and amyloid beta显示文摘 | Du H Yan SS | 2010 | Biochim Biophys Acta2010，1802，1： | 1 |
| 6 | Mitochondrial permeability transition pore in Alzheimer's disease:cyclophilin D and amyloid beta显示文摘 | Du H Yan SS | 2010 | Biochim Biophys Acta2010，1802，1： | 1 |
| 7 | Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system显示文摘 | Yan SS Wu ZY Zhang HP | | 0，，3： | 1 |
| 8 | Determination of polybrominated diphenyl ethers in human semen 显示文摘 | Liu PY Zhao YX Zhu YY Qin ZF Ruan XL Zhang YC Chen B J Li Y Yan SS Qin XF Fu S Xu XB | 2012 | Environ Int2012，，42： | 1 |
| 9 | Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventro- medial medulla with dermorphin-sapofin 显示文摘 | CAO F CHEN SS YAN XF | 2009 | Neurotoxicology2009，30，6： | 1 |
| 10 | In vitro induction and se- lection of fluoroquinolone resistant mutants of Streptococcus pyogenes strains with multiple emm types显示文摘 | Billal DS Fedorko DP Yan SS | 2007 | Antimicrob A- gents Chemother2007，59，1： | 1 |
| 11 | Mitochondrial permeability transition pore in Alzheimer's disease:cyclophilin D and amyloid beta显示文摘 | Du H Yan SS | 2010 | Biochim Biophys Acta2010，1802，1： | 1 |
| 12 | Mitochondrial permeability transition pore is a potential drug target for neurodegeneration显示文摘 | Rao VK Carlson EA Yan SS | 2014 | Biochim Biophys Acta2014，1842，8： | 1 |
| 13 | Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress显示文摘 | Wang SS Yan XB Hofman MA | | 0，，04： | 1 |
| 14 | Mitochondrial permeability transition pore is a potential drug target for neurodegeneration 显示文摘 | Rao VK Carlson EA Yan SS | 2014 | Biochim Biophys Acta2014，1842，8： | 1 |
| 15 | Rh phenotypes of Chinese blood donors in Hong Kong, with special reference to weak D antigens 显示文摘 | Mak KH Yan KF Cheng SS | 1993 | Transfusion1993，33，4： | 1 |
| 16 | Recent advances in laboratory diagnosis of human cytomegalovirus infection显示文摘 | Yan SS Fedorko DP | 2002 | Clin Applied lmmunol Rev2002，2，： | 1 |
| 17 | RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease显示文摘 | Yan SS Chen D Yan S | 2012 | Front Biosci (Schol Ed)2012，4，： | 1 |
| 18 | Study on Qianling Lake restoration with artificial wetland显示文摘 | AO ZQ PENG SS YAN CL | 2009 | Agricultural Science & Technology2009，10，15： | 1 |
| 19 | Effect of inoculating lactic acid bacteria starter cultures on the nitrite concentration of fermenting Chinese paocai显示文摘 | YAN PM XUE WT TAN SS | 2008 | Food Control2008，19，1： | 1 |
| 20 | Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation显示文摘 | Ramasamy R Vannucci SJ Yan SS | 2005 | Glycobiology2005，15，7： | 1 |
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