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| 1 | Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow显示文摘 | Li GR Deng XL Sun H Chung SS Tse HF Lau CP | 2006 | 中国生物学文摘2006，20，5： | 18 |
| 2 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 3 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 4 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 5 | 比较五种中草药牙膏对口腔常见菌的抗菌潜力显示文摘目的评价5种国产中草药牙膏对口腔常见菌的抗菌潜力。方法运用扩散法来评价5种国产中草药牙膏———美加净复合中草药牙膏(MAX)、洁银中药牙膏(JY)、田七特效中药牙膏(TQ)、中华中草药牙膏(ZH)、高露洁草本美白牙膏(Colgate H)对口腔常见菌:变形链球菌(S.mutants)、血链球菌(S.sanguis)、粘放线菌(A.viscosus)和白色念珠菌(C.albicans)的抗菌潜力。结果阴性对照组未见产生抗菌区域,而阳性对照组对4种口腔常见菌产生明显的抗菌区域。TQ对除了白色念珠菌(C.albicans)外的其他3种口腔常见菌都有明显的抗菌作用,其余4种牙膏在膏状和稀释状态下对所有4种常见菌均显示了明显和持续的抗菌作用。膏状状态下的抗菌区域比稀释状态下有显著的增大(P<0.05)。结论除TQ对C.albicans显示无效外,所有5种国产中草药牙膏对口腔内的常见菌均有明显的抗菌作用。 | 陈宏 丁熙 张秀华 ZHANG W LI Y LEE SS | 2007 | 中国微生态学杂志2007，19，4： | 7 |
| 6 | Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue,and its possible role in tumor immunity显示文摘AIM:To investigate the expression of 4-1BB molecule in hepatocellular carcinoma (HCC) and its adjacent tissues.METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the gene expression of 4-1BB in hepatocarcinoma and its adjacent tissues,and peripheral blood mononuclear cells (PBMCs) from both HCC and health control groups.Flow cytometry was used to analyse the phenotypes of T cell subsets from the blood of HCC patients and healthy volunteers,and further to determine whether 4-1BB molecules were also expressed on the surface of CD4+ and CD8+ T cells. The localization of 4-1BB proteins on tumor infiltrating T cells was determined by direct immunofluorescence cytochemical staining and detected by confocal microscopy.RESULTS:4-1BB mRNA, which was not detectable in normal liver,was found in 19 liver tissues adjacent to tumor edge(<1.0cm).Low expression of 4-1BB mRNA was shown in 8 tumor tissues and 6 liver tissues located within 1 to 5cm away from tumor edge. In PBMCs, 4-1BB mRNA was almost not detected. Percentage of CD4^+, CD8^+ and CD3^+/CD25^+ T cells, as well as ratio of CD4 to CD8 revealed no difference between groups (P>0.05,respectively),while a significant lower percentage of CD3^+ T cell was found in HCC group as compared to healthy control group (P<0.05).However, 4-1BB molecules were almost not found on the surface of CD4+ and CD8+ T cells in HCC and healthy control group.Double-staining of 4-1BB^+/CD4^+ and 4-1BB^+/CD8^+ immunofluorescence on tumor infiltrating T cells was detected in 13 liver tissues adjacent to tumor edge (<1.0cm) by confocal microscopy.CONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface,tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment. The present study also implicates that modulating 4-1BB/4-1BBL costimulatory pathway may be an effective immunotherapy strategy to augment the host response. | Wan, YL Zheng, SS Zhao, ZC Li, MW Jia, CK Zhang, H | 2004 | World Journal of Gastroenterology2004，10，2： | 6 |
| 7 | The first internal-tide deposits found in China显示文摘NOT until Gao Zhenzhong and Eriksson studied the Ordovician of Fincastle area, Appalachi-ans, the USA in 1990, did sedimentologist recognize internal-tide deposits in the ancientrecord and begin to use the term of 'internal-tide deposit'. In the Ordovician of Fincastlearea, two facies are recognized: (i) bidirectional cross-laminated very fine grained | Gao, ZZ He, YB Li, JM Li, WF Luo, SS Wang, ZZ | 1997 | Chinese Science Bulletin1997，42，13： | 5 |
| 8 | Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain显示文摘 | Shi M Li SS Zheng C Jones GJ Kim KS Zhou H Kubes P Mody CH | 2010 | J Clin Invest2010，120，5： | 1 |
| 9 | Effect of HPMC and carbopol on the release and floating properties of gastric floating drug delivery system using factorial design显示文摘 | Li SF Lin SS Dagg BP | 2003 | Int J Pharm2003，253，12： | 1 |
| 10 | Mistletoe lectins:telomerase inhibitors in alterative cancer therapy显示文摘 | Li SS | 2002 | Drug Discov Today2002，7，： | 1 |
| 11 | Chronic alcohol intake- induced oxidative stress and apoptosis:role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy显示文摘 | Jing L Jin CM Li SS | 2012 | Mol Cell Biochem2012，359，12： | 1 |
| 12 | The impact of supply chain management practices on competitive advantage and organizational performance 显示文摘 | Li SH Ragu - Nathan B Ragu - Nathan TS Rao SS | 2006 | Omega2006，34，： | 1 |
| 13 | Comparison study of fractional carbon dioxide laser resurfacing using different fluences and densities for acne scars in Asians: a randomized split-face trial 显示文摘 | Yuan XH Zbong SX Li SS | 2014 | Dermatol Surg2014，40，5： | 1 |
| 14 | Emergency laparoseopically assisted right hemicolectomy for obstructing right - sided colon carcinoma 显示文摘 | Ng SS Yiu RY Li JC | 2006 | Laparoendosc Adv Surg Tech2006，16，4： | 1 |
| 15 | Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers:a quantitative overview显示文摘 | Wang JG Li Y Franklin SS | 2007 | Hypertension2007，50，： | 1 |
| 16 | Alterations of the PPP2R1B gene in human lung and colon cancer显示文摘 | Wang SS Esplin ED Li JL | 1998 | Science1998，282，5387： | 1 |
| 17 | The role of SLAM family receptors in immune cell signaling 显示文摘 | Ostrakhoviteh EA Li SS | 2006 | Biochem Cell Biol2006，84，6： | 1 |
| 18 | MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K( + ) channel in after/a/smooth muscle eells显示文摘 | Li SS Ran YJ Zhang DD | 2014 | J Cell Bio- ehem2014，115，6： | 1 |
| 19 | Systematic qualitative and quantitative assessment of fatty acids in the seeds of 60 tree peony(Paeonia section Moutan)cultivars by GC-MS显示文摘 | Li SS Yuan RY Chen LG Wang LS Hao XH Wang LJ Zheng XC Du H | 2015 | Food Chem2015，173，15： | 1 |
| 20 | Hydrogen sulfide maintains mitochondrial DNA replication via demethylation of TFAM显示文摘 | LI SS YANG GD | | Antioxid Redox Signal0，23，7： | 1 |
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