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| 1 | Alteration of the intrinsic apop- tosis pathway is involved in Notch-induced chemoresistance to gemcitabine in pancreatic cancer显示文摘 | Du X Zhao YP Zhang TP | 2014 | Arch Med Res2014，45，1： | 1 |
| 2 | NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states 显示文摘 | Ellen TP Ke Q Zhang P | 2008 | Carcinogenesis2008，29，： | 1 |
| 3 | Anxiolytic-and antidepressant-like profiles of the galanin-3 receptor (Ga13)antagonists SNAP 37889 and SNAP 398299显示文摘 | Swanson CJ Blackburn TP Zhang X et al | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 4 | NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states 显示文摘 | Ellen TP Ke Q Zhang P | 2008 | Carcinogenesis2008，29，1： | 1 |
| 5 | Ghrelin expression in the tissue of different thyroid disease显示文摘 | Zhang YF Wang HN Hong TP | 2006 | Beijing Da Xue Xue Bao2006，38，2： | 1 |
| 6 | Evacetrapib is a novel, potent and selective inhibitor of eholesteryl ester transfer protein that ele- vates high-density lipoprotein cholesterol without inducing aldoste- rone or increasing blood pressure 显示文摘 | Cao G Beyer TP Zhang Y | 2011 | J Lipid Res2011，52，12： | 1 |
| 7 | Monoclonal side population progenitors isolated from human fetal pancreas显示文摘 | Zhang L Hu J Hong TP | | 0，，： | 1 |
| 8 | Improved cathode materials for microbial electrosynthesis 显示文摘 | Zhang T Nie H Bain TS Lu H Cui M Snoeyenbos-West OL Franks AE Nevin KP Russell TP Lovley DR | 2012 | Energy Environ Sci2012，6，1： | 1 |
| 9 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 10 | Surgical management of pa- tients with insulinomas : Result of 292 cases jn a single institution 显示文摘 | Zhao YP Zhan HX Zhang TP | 2011 | JSurgOncol2011，103，2： | 1 |
| 11 | Repairable Consecutive -2-out-of-n:G System显示文摘 | Zhang YL Wang TP | 1996 | Microelectronics and Reliability1996，36，： | 1 |
| 12 | NDRG1,a growth and cancer related gene:regulation of gene expression and function in normal and disease states显示文摘 | Ellen TP Ke Q Zhang P | 2008 | Carcinogenesis2008，29，1： | 1 |
| 13 | Urban contamination of the Chicago coastal Lake Michigan atmosphere by PCBs and PAHs during AEOLOS显示文摘 | Simcik MF Zhang H Franz TP | 1997 | Environ Sci Technol1997，31，： | 1 |
| 14 | Improved cathode materials for microbial electrosynthesis 显示文摘 | Zhang T Nie H Bain TS Lu H Cui M Snoeyenbos-West OL Franks AE Nevin KP Russell TP Lovley DR | 2013 | Energy Environ Sci2013，6，1： | 1 |
| 15 | A natural product ligand of the oxysterol receptor,liver X receptor显示文摘 | Bramlett KS Houck KA Borchert KM Dowless MS Kulanthaivel P Zhang Y Beyer TP Schmidt R Thomas JS Michael LF Barr R Montrose C Eacho PI Cao G Burris TP | | 0，，01： | 1 |
| 16 | NDRG1 ,a growth and cancer related gene:regulation of gene expression and function in nor-real and disease states显示文摘 | Ellen TP Ke Q Zhang P | 2008 | Carcinogenesis2008，29，1： | 1 |
| 17 | Acid-degradablecore-crosslinked micelles prepared from thermosensitive glyco-polymers synthesized via RAFT polymerization 显示文摘 | ZHANG L BERNARD J DAVIS TP | 2008 | MacromolRapid Comm2008，29，2： | 1 |
| 18 | Study of injury effect of anoxia on neonatical rats’myocardial cells显示文摘 | Zhang X Liu HW Zhou TP | 2002 | J West China Univ Med Sci( in Chinese)2002，33，： | 1 |
| 19 | Thymidine phosphorylase in angiogenic and promotes tumor growth显示文摘 | Moghaddam A Zhang HT Fan TP | 1995 | Proc Natl Acad Sei USA1995，99，4： | 1 |
| 20 | Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 ceils 显示文摘 | Li J J Zhang TP Meng Y | 2011 | Cell Physiol Biochem2011，27，5： | 1 |
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