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| 1 | Nia1 and Nia2 are Involved in Exogenous Salicylic Acid-induced Nitric Oxide Generation and Stomatal Closure in Arabidopsis显示文摘Phytohormone salicylic acid (SA) plays important roles in plant responses to environmental stress. However, knowledge about the molecular mechanisms for SA affecting the stomatal movements is limited. In this paper, we demonstrated that exogenous SA significantly induced stomatal closure and nitric oxide (NO) generation in Arabidopsis guard cells based on genetic and physiological data. These effects were significantly inhibited by the NO scavenger c-PTIO, NO synthase (NOS) inhibitor L-NAME or nitrate reductase suppressor tungstate respectively, implying that NOS and nitrate reductase (NR) participate in SA-evoked stomatal closing. Furthermore, the effects of SA promotion of stomatal closure and NO synthesis are significantly suppressed in NR single mutants of nia1, nia2 or double mutant nia1/nia2, compared with the wild type plants. This suggests that both Nia1 and Nia2 are involved in SA-stimulated stomatal closure. In addition, pharmacological experiments showed that protein kinases, cGMP and cADPR are involved in SA-mediated NO accumulation and stomatal closure induced by SA in Arabidopsis. | Fushun Hao Shiling Zhao Huan Dong Huan Zhang Lirong Sun Chen Miao | 2010 | Journal of Integrative Plant Biology2010，52，3： | 8 |
| 2 | Counterintuitive Ballistic and Directional Liquid Transport on a Flexible Droplet Rectifier显示文摘Achieving the directional and long-range droplet transport on solid surfaces is widely preferred for many practical applications but has proven to be challenging.Particularly,directionality and transport distance of droplets on hydrophobic surfaces are mutually exclusive.Here,we report that drain fly,a ubiquitous insect maintaining nonwetting property even in very high humidity,develops a unique ballistic droplet transport mechanism to meet these demanding challenges.The drain fly serves as a flexible rectifier to allow for a directional and long-range propagation as well as self-removal of a droplet,thus suppressing unwanted liquid flooding.Further investigation reveals that this phenomenon is owing to the synergistic conjunction of multiscale roughness,structural periodicity,and flexibility,which rectifies the random and localized droplet nucleation(nanoscale and microscale)into a directed and global migration(millimeter-scale).The mechanism we have identified opens up a new approach toward the design of artificial rectifiers for broad applications. | Lei Wang Jing Li Bo Zhang Shile Feng Mei Zhang Dong Wu Yang Lu Ji Jung Kai Jing Liu Zuankai Wang Lei Jiang | 2020 | Research2020，，1： | 6 |
| 3 | Four Methods to Estimate Minimum Miscibility Pressure of CO2-Oil Based on Machine Learning显示文摘Summary of main observation and conclusion CO2 flooding accounts for a considerable proportion in gas flooding.Using CO2 as a gas displacement agent is benefit for enhanced oil recovery(EOR),and the alleviation of the greenhouse effect by the permanent storage of CO2 in the crust.Minimum miscibility pressure(MMP)of CO2-oil is a key factor affecting EOR,which determines the yield and economic benefit of crude oil recovery.Therefore,it is of great importance to use fast,accurate and cheap prediction methods for MMP estimation.In the present study,to evaluate the reliability of four recently developed prediction models based on machine learning(i.e.,neural network analysis(NNA),genetic function approximation(GFA),multiple linear regression(MLR),partial least squares(PLS)),136 sets of data are selected for calculation via outlier analysis from 147 sets of data.Afterwards,we compared the four models with existing prediction models from the literature.The analysis of correlation coefficients and multiple error functions shows that the four models can solve the MMP prediction problem well,and the model using intelligent algorithm has a higher prediction accuracy than the simple linear model.Besides,intelligent methods based on similarity algorithm have little difference from each other.Finally,a sensitivity analysis was conducted. | Ding Li Xiangliang Li Yinghua Zhang Lixin Sun Shiling Yuan | 2019 | Chinese Journal of Chemistry2019，37，12： | 4 |
| 4 | Kinetic Model of Fixed Bed Reactor with Immobilized Microorganisms for Removing Low-Concentration SO_2显示文摘根据对待二氧化硫( SO2 )的低集中的过程的分析在一个固定床反应堆的气体,一个运动模型在考虑内部散开的效果以后为这个过程被建议,房间集中,并且微生物的生产产量但是忽略外部散开的效果。从模型模拟获得的结果证明这个模型能显示过程因素的影响, Cin ,|?,| ìm 斧子, Cx , A , h , Km ,和 Q ,在 SO2 的移动上并且由这个模型的结果的预言也是令人满意的。这个运动模型能也关于生物反应器的微生物,以及设计的合适的种类的使不能调动的微生物,选择和驯服的准备提供一些很重要的指示。给词调音:固定床反应堆;运动模型;使不能调动的微生物;移动; | Bing Huang YanyanWang Shiling Zhang Yong Ao | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 3 |
| 5 | Influence of Ganoderma lucidum spores on the levels of neuropeptide Y and somatostatin in brains of seizure rats显示文摘BACKGROUND: Previous research has revealed that somatostatin can induce epilepsy, and that the levels of neuropeptide Y may increase and become more active in brain areas with epileptic seizures. OBJECTIVE: To observe the effect of Ganoderma lucidum spore powder on the neuropeptide Y and somatostatin content in the cerebral cortex and hippocampal regions of seizure rats induced by pentylenetetrazol (PTZ). Furthermore, to verify any effect of Ganoderma lucidum spore powder on inhibition of epileptic seizures. DESIGN, TIME AND SETTING: A randomized group animal study was performed in August 2007 in the School of Basic Medical Sciences, Jiamusi University (Jiamusi, Heilongjiang, China). MATERIALS: Thirty healthy, male, Wistar rats, aged 12 weeks and weighing 180–220 g, were taken as the experimental animals. PTZ (Sigma Company, United States) was used to induce epilepsy. Ganoderma lucidum spores (Leyss, ex Fr variety) were purchased from Jiamusi City Wild Growing Case of the Ganoderma Lucidum (China). Rabbit anti-somatostatin antibodies and secondary antibodies were purchased from Wuhan Boster Company (China). Neuropeptide Y radioimmunoassay kit was purchased from Beijing Furui Biotechnology Company (China). METHODS: Thirty rats were randomly divided into three groups: a control group, an epilepsy model group and a Ganoderma lucidum spore-treated group. Each group contained 10 animals. Rats in the epilepsy model group were treated with intraperitoneal injections of PTZ and gastric perfusion of physiologic saline. In the Ganoderma lucidum spore-treated group, intraperitoneal injection of PTZ and gastric perfusion of Ganoderma lucidum spore powder were administered. The blank control group was only administered with the physiological saline by intraperitoneal injection and gastric perfusion. MAIN OUTCOME MEASURES: Immunohistochemical staining and radioimmunoassay methods were used to observe the changes of somatostatin and neuropeptide Y content in brain tissue of epileptic rats, as well as the morphology of neurons. RESULTS: All 30 rats were involved in the result analysis, without any loss. The number of somatostatin immunoreacted positive cells in the cerebral cortex and hippocampus was significantly increased in the epilepsy model group compared to the blank control group (P < 0.01). The number of somatostatin immunoreacted positive cells in cerebral cortex and hippocampus was significantly decreased in the Ganoderma lucidum spore-treated group compared to the epilepsy model group (P < 0.01). The contents of neuropeptide Y in cerebral cortex and hippocampus were significantly increased in the epilepsy model group compared to the blank control group (P < 0.01). The contents of neuropeptide Y in the cerebral cortex and hippocampus were significantly decreased in the Ganoderma lucidum spore-treated group compared to the epilepsy model group (P < 0.05). The epilepsy seizures in the Ganoderma lucidum spore-treated group were obviously reduced compared to the epilepsy model group. CONCLUSION: Ganoderma lucidum spore powder was able to reduce the somatostatin and neuropeptide Y content in the cerebral cortex and hippocampus effectively, so as to achieve an anti-epileptic function and protect neurons from being damaged. | Kongli Zhu Ming Lu Shuqiu Wang Shiling Zhang Dixiang Sun | 2008 | Neural Regeneration Research2008，3，5： | 3 |
| 6 | Ultrasensitive detection of aliphatic nitro-organics based on“turn-on”fluorescent sensor array显示文摘The broad class of explosives includes nitro aromatics as well as challenging aliphatic nitro-organics whose detection is important from counter-terrorism and national security perspectives.Here we report a turn-on fluorescent sensor array based on aggregation-induced emission(AIE)fluorophores as receptors.To achieve a good sensing system with fast response,good sensitivity and low detection limit,three receptors with abundant chemical diversities for target analytes were synthesized.The turn-on response of the individual receptor showed highly variable and cross-reactive analyte-dependent changes in fluorescence.The excellent ability to identify a variety of explosives,especially the challenging aliphatic nitro-organics(2,3-dimethyl-2,3-dinitrobutane(DMNB),1,3,5-trinitro-1,3,5-triazinane(RDX),cyclotetramethylene tetranitramine(HMX)and entaerythritol tetranitrate(PETN)),was demonstrated in qualitative and quantitative analyses with 100%accuracy.The fluorescence signal amplification in the presence of explosives allows for application of these receptors in a sensor microarray suitable for high-throughput screening.These results suggested that the cross-reactive sensor array based on AIE fluorophores could find a wide range of applications for sensing various analytes or complex mixtures. | Chen Wang Heng Zhang Li Tian Wei Zhu Yue Lan Jian Li Hui Wang Guanxin Zhang Deqing Zhang Shiling Yuan Guangtao Li | 2016 | Science China Chemistry2016，59，1： | 2 |
| 7 | Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication显示文摘Rabies is caused by infection of rabies virus(RABV)and remains a serious threat to the global public health.Except for the requirement for cold chain and high cost of human rabies immune globulin,no small molecule drugs are currently available for clinical treatment of rabies.So,it is of great importance to identify novel compounds that can effectively inhibit RABV infection.Artesunate(ART)and dihydroartemisinin(DHA),two derivatives of artemisinin,are widely used for treatment of malaria in adults and children,showing high safety.In this study,we found that both ART and DHA were able to inhibit RABV replication in host cells at a low concentration(0.1μmol/L).The antiviral effects of ART and DHA were independent of viral strains and cell lines.Pre-treatment with ART or DHA for 2 h in vitro did not affect the viral replication in host cells,implying that ART and DHA neither reduced the viability of RABV directly nor inhibited the binding and entrance of the virus to host cells.Further studies revealed that ART and DHA inhibited RABV genomic RNA synthesis and viral gene transcription.Treatment with ART or DHA(5 mg/kg)by intramuscular injection improved,to some extent,the survival rate of RABV-challenged mice.Combination treatment with derivatives of artemisinin and mannitol significantly improved the survival rate of RABV-challenged mice.The results suggest that ART and DHA have a great potential to be explored as new anti-rabies agents for treatment of rabies. | Jun Luo Yue Zhang Yang Wang Qing Liu Jiesen Li Hongling He Yongwen Luo Shile Huang Xiaofeng Guo | 2021 | Virologica Sinica2021，36，4： | 2 |
| 8 | Effects of Ganoderma lucidum spore powder on astrocyte expression and glutamine synthetase activity in the hippocampal region of epileptic rats显示文摘BACKGROUND: Recent studies have demonstrated that astrocyte dysfunction plays a central role in inhibiting epileptic seizures and that regulation of astrocyte function may be a new target for treatment of epilepsy. OBJECTIVE: To observe the effects of Ganoderma lucidum spore powder (GLSP) on astrocyte morphology and glutamine synthetase (GS) activity in the hippocampal region of epileptic rats. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Function Laboratory, College of Basic Medicine, Jiamusi University between October and December 2006. MATERIALS: A total of 30 Sprague Dawley (SD) rats were randomized to three groups (n = 10): control, model, and GLSP. GLSP was sourced from Jiamusi Wild Ganoderma Lucidum Planting Base and prepared to 30 g/L with physiological saline before use. Pentylenetetrazol (PTZ) (10 g/L) was provided by Sigma Company, USA. METHODS: The control group received intraperitoneal (i.p.) and intragastric (i.g.) physiological saline. Following epilepsy induction by i.p. administration of PTZ (35 mg/kg), rats from the model and GLSP groups were ig injected with physiological saline and GLSP (300 mg/kg), respectively. Each compound was administered once per day, for a total of 28 successive days. Epileptic seizure convulsions were graded 0–5. A higher grade indicated more severe epilepsy. Only those rats showing stage 2 or higher convulsions at least 5 times successively were included in further experiments. MAIN OUTCOME MEASURES: Immediately after injection, seizure activity was monitored for 30 minutes to determine the latent period and seizure duration; simultaneously, astrocyte numbers and GS activity in the hippocampal region of rats with epilepsy were detected by immunohistochemistry. RESULTS: All 30 rats were included in the final analysis. On day 28, following PTZ administration epileptic seizures were not found in the control group. In the GLSP group, rats exhibited rhythmic head nodding or facial spasms, and the latent period was significantly longer than that of the model group (P < 0.05). In the model group, the majority of rats exhibited myoclonus or generalized convulsions, and epileptic seizure duration was slightly (but not significantly) longer than that in the GLSP group (P > 0.05). Within 2–3 minutes of PTZ injection, the model group exhibited grade 4 or 5 epileptic seizures, and the GLSP group mostly showed grade 2 or 3, and occasionally grade 4 or 5, epileptic seizures. All rats recovered within 30 minutes. The model group exhibited significantly increased astrocytes (P < 0.05), with thicker cellular processes and a higher number of cellular processes, and significantly decreased GS activity (P < 0.05) than the control group. The astrocyte count was significantly decreased but GS activity was significantly increased in the GLSP group when compared with the model group (P < 0.05); however, astrocyte appearance was similar in both groups (P < 0.05). CONCLUSION: GLSP can effectively inhibit astrocyte numbers and elevate GS activity in the hippocampal region of rats with epilepsy, thereby reducing epileptic seizures. | Shiling Zhang Shuqiu Wang | 2008 | Neural Regeneration Research2008，3，12： | 2 |
| 9 | Circulating microR- NAs,potential biomarkers for drug- induced liver injury 显示文摘 | Kai Wang Shile Zhang Bruz Marzolf | 2009 | Proc Natl Acad Sci USA2009，106，11： | 1 |
| 10 | 显示文摘 | Bing Huang Yanyan Wang Shiling Zhang Yong Ao Faculty of Environmental Science & Engineering Kunming University of Science and Technology Kunming 650093 Yunnan China Faculty of Science Kunming University of Science and Technology Kunming 650093 | 2007 | Journal of Natural Gas Chemistry2007，，01： | 1 |
| 11 | The MicroRNA Spectrum in 12 Body Fluids显示文摘 | Weber Jessica A Baxter David H Zhang Shile Huang David Y Huang Kuo How Lee Ming Jen Galas David J Wang Kai | 2010 | Clinical Chemistry2010，，： | 1 |
| 12 | Anti-allergic effects of low molecular weight heparin 显示文摘 | Wang Qingli Shang Xueyuan Zhang Shiling | 1999 | J Chin Pharm Sci1999，8，3： | 1 |
| 13 | Helium Bubble Growth in He^(+) Ions Implanted 304L Stainless Steel Processed by Laser Powder Bed Fusion During Post-Irradiation Annealing at 600℃显示文摘The abundancy of defect sinks in the microstructure of laser powder bed fusion(LPBF) processed austenitic stainless steels was found to be beneficial for helium resistance.In the current study,the influence of the novel microstructure in LPBF processed 304 L on the helium bubble growth behaviour was investigated using transmission electron microscopy in samples implanted with He^(+) ion and post-irradiation annealing treated at 600℃ for 1 h.Two variants of LPBF processed 304 L samples were used,one in as-built condition and the other solution-annealed.The comparison between the two samples indicated that the helium bubble growth was inhibited and remained stable in the as-built sample but coarsened significantly in the solution-annealed sample.The sub-grain boundaries and oxide nano-inclusions acted as defect sinks to trap helium atoms and inhibited the growth of helium bubble in the as-built sample under the post-irradiation annealing conditions used. | Hui Liu Shiling Min Menglei Jiang Fuzhong Chu Ying Li Zhuoer Chen Kai Zhang Juan Hou Aijun Huang | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 1 |
| 14 | ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells显示文摘Ganoderma lucidum(G.lucidum)extracts,as dietary supplements,have been found to exert potent anticancer activity,which is attributed to the presence of polysaccharides and triterpenes.However,the molecular mechanism underlying the anticancer action of G.lucidum extracts remains to be investigated.Here,we show that ReishiMax GLp,containing G.lucidum polysaccharides and triterpenes(GLPT),inhibited cell proliferation and induced cell death in human lung cancer cells(A549 and A427)and simultaneously suppressed the signaling pathways of mammalian target of rapamycin complexes 1 and 2(mTORC1 and mTORC2),respectively.Mechanistically,GLPT downregulated the phosphorylation and protein levels of insulin-like growth factor 1 receptor(IGFR)and phosphoinositide 3-kinase(PI3K)as well as the protein level of RAS homolog enriched in brain(Rheb).In addition,GLPT also activated the AMP-activated protein kinase(AMPK)network.This was evidenced by observations that GLPT increased the phosphorylation of AMPKα(T172)and its substrates tuberous sclerosis complex 2(TSC2,S1387)and regulatory-associated protein of mTOR(raptor,S792).Ectopic expression of dominant-negative AMPKαpartially mitigated the inhibitory effect of GLPT on mTORC1,indicating that GLPT inhibits mTORC1 partly by activating AMPK.The results suggest that G.lucidum extracts exert anticancer action at least partly by suppressing mTORC1/2 signaling via activation of AMPK and inhibition of IGFR/PI3K/Rheb in tumor cells. | Didem Sohretoglu Chao Zhang Jun Luo Shile Huang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 1 |
| 15 | Synthesis of an acrylate elastomer with UV stabiliza tion and its applica- tion in polyoxymethylene 显示文摘 | WU Guibo YANG Fan ZHANG Shiling | 2012 | J Appl Polym Sci2012，123，： | 1 |
| 16 | Surface characterization of poly(methyl methacrylate-co-n-butyl acrylate-co-cyclopentylstyryl-polyhedral oligomeric silsesquioxane) by inverse gas chromatography显示文摘 | Zou Qichao Zhang Shiling Tang Qingqiong | 2006 | Journal of Chromatography A2006，1110，12： | 1 |
| 17 | Decompositions of stochastic convolution driven by a white-fractional Gaussian noise显示文摘Let u={u(t,x);(t,x)∈R_(+)×R}be the solution to a linear stochastic heat equation driven by a Gaussian noise,which is a Brownian motion in time and a fractional Brownian motion in space with Hurst parameter H∈(0,1).For any given x∈R(resp.,t∈R_(+)),we show a decomposition of the stochastic process t(→)u(t,x)(resp.,x(→)u(t,x))as the sum of a fractional Brownian motion with Hurst parameter H/2(resp.,H)and a stochastic process with C^(∞)-continuous trajectories.Some applications of those decompositions are discussed. | Ran WANG Shiling ZHANG | 2021 | Frontiers of Mathematics in China2021，16，4： | 0 |
| 18 | Reductive degradation of chloramphenicol by Geobacter metallireducens显示文摘Geobacter metallireducens is known to be capable of removing nitroaromatic compounds via an oxidation mode. However, little attention has been paid to investigate the reductive removal of chlorinated nitroaromatic compounds by G. metallireducens. In this study, G. metallireducens was used to reduce chloramphenicol(CAP), a typical chlorinated nitroaromatic antibiotic. Cyclic voltammograms and chronoamperometry highlighted a higher peak current for CAP reduction by G. metallireducens compared to the control without bacteria. G. metallireducens efficiently reduced CAP(20 mg/L) with acetate as the sole electron donor, and the removal efficiency reached(97.6±4.9)% within 6 d. Aromatic amine(AMCl2), AMCl(dechlorinated AMCl2) and AM(dechlorinated AMCl) were identified as reduction products by liquid chromatography-mass spectrometry. However, the removal efficiency declined to(25.0±3.6)% when the CAP dosage increased to 80 mg/L. Transcriptomic analysis indicated the significant upregulation of genes related to electron transfer, such as pilus assembly protein gene(2.8 folds), NADH-quinone oxidoreductase subunit K2 gene(4.5 folds) and many c-type cytochrome genes such as cytochrome c biogenesis protein Res B(Gmet 2901, 4.6 folds), cytochrome c(Gmet 0335, 4.4 folds) and cytochrome c7(Gmet 2902, 3.4 folds). Furthermore, a gene related to chlorinated contaminant removal(Gmet 1046, 5.4 folds) was also upregulated, possibly resulting in enhanced CAP reduction. This work deepened our knowledge of the bioremediation ability of G. metallireducens with respect to environmental contaminants and provided a potential strategy to treat antibiotics with electrochemically active bacteria. | XU HengDuo XIAO LeiLei ZHENG ShiLing ZHANG YueChao LI JiaJia LIU FangHua | 2019 | Science China(Technological Sciences)2019，62，10： | 0 |
| 19 | Atomistic Insights into Oxidation of Chemical Passivated Silicon(100)Surface:Reactive Molecular Dynamic Simulations显示文摘Main observation and conclusion In this paper,a series of ReaxFF molecular dynamic simulations were performed to study the oxidation of chemical passivated silicon(100)surface,which was terminated with different n-alkyl chains.The simulated results showed that the oxidant species diffuse into Si substrate through peroxy-like structures during the oxidation process.During the oxidation process,the Si-alkyl(Si-C)covalent bond was stable and there is no occurrence of decomposition of the n-alkyl chains.In addition,the existence of n-alkyl monolayers on silicon surface did not change the initial reaction pathway of the oxidation process.The simulations indicated that the chemical passivation mechanism includes two parts,one is about the Si-C covalent bond occupying the active site of the reaction on Si(100)surface,and the other is about the oxygen penetrating Si-alkyl layers.The simulations also indicated that the chemical passivation of Si-alkyl is better for longer alkyl chains,which is consistent with the experimental observation.Our results have investigated the oxidation of chemical passivated silicon(100)surface at the atom level,which is helpful to comprehend the manufacture of semiconductor devices like metal-oxide-semiconductor(MOS)devices in the experiments. | Shideng Yuan Xueyu Wang Heng Zhang Shiling Yuan | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
| 20 | Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8+T cell proportion in tumor-bearing mice through the USP9X signaling pathway显示文摘The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective therapeutics.Our research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8+T cells in tumor-bearing mice,thus restraining tumor growth.Investigation into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X,undermining its role in shieldingβ-catenin.This leads to a reduction in the expression of downstream effectors in the Wnt signaling pathway.These findings indicate that Ng-Ft1 could be a promising small-molecule treatment for CRC,working by blocking tumor progression via the Wnt signaling pathway and augmenting CD8^(+)T cell prevalence within the tumor environment. | FENG Yutao LI Yuan MA Fen WU Enjiang CHENG Zewei ZHOU Shiling WANG Zhengtao YANG Li SUN Xun ZHANG Jiwei | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
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