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| 1 | 聚集诱导发光探针分子在荧光传感中的应用显示文摘荧光传感作为化学传感领域中的一项重大技术,具有灵敏度高、选择性好和响应快等优点,但是传统有机发光分子在高浓度或者聚集状态下,容易发生荧光强度的降低或是完全消失,这在一定程度上不利于其在应用中发挥最佳效果.聚集诱导发光(AIE)概念的提出为解决聚集导致发光猝灭(ACQ)的难题提供了方案,实现了发光分子在聚集态下的高荧光量子产率.具有AIE特性的发光分子被用作荧光传感器不仅具有高亮度的荧光信号,而且不必担心由于分子聚集导致的荧光信号的降低或猝灭.同时,由于某些分子聚集程度的增强导致的荧光颜色和强度的变化,可以被用来实现对靶标物的定性和定量分析.本文简述了近几年来AIE分子在荧光传感方面的应用,如离子检测、气体、有机小分子、爆炸物、蛋白质及酶等化学/生物传感器,同时对基于AIE分子的荧光传感器在设计和应用前景做了展望. | 杜宪超 王佳 秦安军 唐本忠 | 2020 | 科学通报2020，65，15： | 9 |
| 2 | Multiple genotyping based on multiplex PCR and microarray显示文摘The genetic variability has obtained more and more attention in the process of diagnosis and treatment of tumors.Herein,we have described a multiple genotyping method based on magnetic enrichmentmultiplex PCR(MEM-PCR) and microarray technology.Monodisperse magnetic beads were fabricated and modified with streptavidin.Four loci on two genes(M235T and A-6G loci on AGT gene,A1298 C and C677 T loci on MTHFR gene) were selected to study single nucleotide polymorphisms(SNP).Target sequences of these SNP loci were amplified using Cy3-labeled primers through multiplex PCR in one tube after the templates were enriched and purified by functional magnetic beads(MB).Four pairs of NH_2-labeled probes,corresponding to each locus,were fixed on CHO-modified glass slide by covalent binding.Hybridization between target sequences and probes was performed under suitable conditions.The spotting locations on microarray and the ratio of fluorescence intensity,produced by different loci,were used to distinguish the SNP genotypes.Finally,three of gastric cancer samples were collected and genotyping analysis for these four SNP loci was carried out successfully simultaneously by this method. | Xian-Bo Mou Zeeshan Ali Bo Li Tao-Tao Li Huan Yi Hong-Ming Dong Nong-Yue He Yan Deng Xin Zeng | 2016 | Chinese Chemical Letters2016，27，11： | 0 |
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