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| 1 | Insulin sensitizers for the treatment of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the leading cause of liver disease in the Western world and is closely associated with metabolic syndrome,which includes hypertension,central obesity,dyslipidemia and insulin resistance.NAFLD includes a wide spectrum of liver alterations,ranging from simple hepatic steatosis to variable degrees of fibrosis,cirrhosis and even hepatocellular carcinoma.Although the etiology and progression of the disorder remain poorly understood,insulin resistance is considered to play a pivotal role in the pathogenesis.Insulin sensitizers such as biguanides,thiazolidinediones(TZDs),glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors have been studied as therapeutic approaches for NAFLD in recent years.Metformin improves insulin sensitivity and serum alanine transaminase and aspartate transaminase(ALT/AST) levels in the majority of subjects; however,it has no significant effect on liver histology.TZDs improve insulin sensitivity,serum ALT/ AST levels and histology in some cases,but there are some concerns about the safety of long-term therapy.Selection of appropriate patients for avoiding side effects and the treatment of underlying disease are themain points.These drugs are the best choice for the treatment of NAFLD in patients with type 2 DM who are also candidates for treatment with an insulin sensitizer.The present review provides an overview of insulin sensitizers in the treatment of NAFLD. | Zeynel Abidin Ozturk Abdurrahman Kadayifci | 2014 | World Journal of Hepatology2014，6，4： | 14 |
| 2 | Treatment of type 2 diabetes mellitus in the elderly显示文摘The prevalence of type 2 diabetes is expected to increase gradually with the prolongation of population aging and life expectancy. In addition to macrovascular and microvascular complications of elderly patients of diabetes mellitus, geriatric syndromes such as cognitive impairment, depression, urinary incontinence,falling and polypharmacy are also accompanied by aging. Individual functional status in the elderly shows heterogeneity so that in these patients, there are many unanswered questions about the management of diabetes treatment. The goals of diabetes treatment in elderly patients include hyperglycemia and risk factors, as in younger patients. comorbid diseases and functional limitations of individuals should be taken into consideration when setting treatment targets. Thus, treatment should be individualized. In the treatment of diabetes in vulnerable elderly patients, hypoglycemia, hypotension, and drug interactions due to multiple drug use should be avoided. Since it also affects the ability to self-care in these patients, management of other concurrent medical conditions is also important. | Funda Datli Yakaryilmaz Zeynel Abidin Oztürk | 2017 | World Journal of Diabetes2017，8，6： | 4 |
| 3 | Investigation and modeling of water quality of Goksu River (Cleadnos) in an international pro- tected area by using GIS显示文摘Gksu Delta is an important wetland where the Gksu River reaches to sea in the eastern of the town Tasucu-Ice1. The delta is classified as a Wetland of International Impor-tance according to the Ramsar Convention on Wetlands of International Importance. The amount of fertilizers used in this area was 7200 tons in 2006. These pollutants affect the surface and groundwater quality negatively. The intensively used fertilizers and pesticides contain not only N- and P compounds but also some heavy metals. The contents of all pol-lutants in surface waters were determined for four different seasons between 2006 and 2008 and with these data a Geographic Information System (GIS) has been constructed by using Map Info. From the photometric heavy metal analysis, it is inferred that the excess concen-tration of Fe, Ni, Mn, Mo and Cu at some locations is the cause of undesirable quality for drinking purposes. The source of excess concentration of various heavy metals is the agri-cultural activities and fertilizers. It is determined that in all periods between 2006 and 2008 the heavy metals and other pollutants in the fertilizers and pesticides transported easily to river water with irrigation return flow. The organic pollutants, including COD, BOD, NH3 and NO3 followed the sharply increasing trends from Silifke city to Mediterranean Sea. The water quality of Gksu River is modeled and determined that the waste water discharge of 10,700 m3/day from Silifke city does not create a serious problem because of the high amount of flow rate of Gksu River. | Zeynel DEMIREL Zafer OZER Olcay OZER | 2011 | Journal of Geographical Sciences2011，21，3： | 3 |
| 4 | Effects of body mass index on intraocular pressure and ocular pulse amplitude显示文摘AIM: To investigate the effects of body mass index (BMI) on intraocular pressure (IOP) and ocular pulse amplitude(OPA). METHODS: Totally 140 healthy individuals without any systemic diseases were included in the study. BMI (kg/m2) was calculated for every individual. IOP and OPA were measured with Pascal Dynamic contour tonometer (DCT). Blood pressure was also measured along with the DCT. The patients were divided into three groups according to BMI as: Group1, BMI<25; Group2, 25≤BMI<30; Group3, BMI≥30. Mean values of IOP, OPA, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were used in statistical analysis.RESULTS: In Group1, the means of IOP, OPA, were 16.8±2.3mmHg, 2.7±0.7mmHg respectively; and SBP, DBP were 120.0±6.1mmHg, and 77.4±5.6mmHg respectively. In group2, the mean IOP, OPA, SBP, and DBP were found to be 16.6±2.1mmHg, 2.4±0.7mmHg, 121.7±5.3mmHg, and 79.5±4.9mmHg respectively. In group3, the mean IOP, OPA, SBP, and DBP were found to be 17.3±1.7mmHg, 2.1±0.7mmHg, 122.4±5.7mmHg, and 79.7±5.2mmHg respectively. There were no statistically significant difference between groups in terms of IOP, SBP and DBP, while OPA values were significantly lower in group3 (P=0.001). CONCLUSION: Decreased OPA values in individuals with higher BMI may indicate that subjects with higher BMI have lower choroidal perfusion and lower ocular blood flow. | Remzi Karadag Zeynel Arslanyilmaz Bahri Aydin Ibrahim F. Hepsen | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 3 |
| 5 | Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey显示文摘 | Filiz Akyuz Fatih Besisik Duran Ustek Cumhur Ekmek?i Aytul Uyar Binnur Pinarbasi Kadir Demir Sadakat Ozdil Sabahattin Kaymakoglu Gungor Boztas Zeynel Mungan Ahmet Gul | 2013 | Journal of Clinical Gastroenterology2013，，3： | 1 |
| 6 | Economic growth and energy consumption causal nexus viewed through a bootstrap rolling window 显示文摘 | Mehmet Balcilar Zeynel Abidin Ozdemir and Yalcin Arslanturk | 2011 | Energy policy2011，，6： | 1 |
| 7 | Linkages between the center and periphery stock prices:Evidence from the vector ARFIMA model显示文摘 | Hasan Olgun Zeynel Abidin Ozdemir | 2008 | Economic Modelling2008，，25： | 1 |
| 8 | Tigecycline treatment of multi‐drug‐resistant Corynebacterium jeikeium infection in a child with relapsing and refractory acute lymphoblastic leukemia显示文摘 | Ener CagriDinleyici Zeynel AbidinYargic OzcanBor AbdurrahmanKiremitci GulDurmaz | 2010 | Pediatr Blood Cancer2010，，2： | 1 |
| 9 | Metamorphic hosted pyrophyllite and diekite occurrences from the hydrous Al-silicate deposits of the Malatya-Puturge region,central eastern Anatolia,Turkey显示文摘 | Bozkaya Omer Yalcin Hiaseyin Basibtiytik Zeynel | 2007 | Clay Minerals Society2007，，4： | 1 |
| 10 | Economic Growth and Energy Consumption Causal Nexus Viewed through a Bootstrap Rolling Window显示文摘 | Mehmet Balcilar Zeynel Abidin Ozdemir Yalcin Arslanturk | 2010 | Energy Economics2010，，32： | 1 |
| 11 | Inlet patch: Associations with endoscopic findings in the upper gastrointestinal system显示文摘 | ?lhami Yüksel O?uz üsküdar Seyfettin K?klü ?mer Ba?ar Selcan Gültuna Selman ünverdi Zeynel A. ?ztürk Demet ?engül Ata Türker Arik?k Osman Yüksel ?ahin ?oban | 2008 | Scandinavian Journal of Gastroenterology2008，，8： | 1 |
| 12 | Risk Factors for Metastasis in Retinoblastoma显示文摘 | Paul T Finger J.William Harbour Zeynel A Karcioglu | 2002 | Survey of Ophthalmology2002，，1： | 1 |
| 13 | 查看详情显示文摘 | Aytül S Zeynel S Nermin E | | 0，，2： | 1 |
| 14 | Synthesis and crystal structures of two hetarylazo indole disperse dyes显示文摘 | SEFEROGLU Zeynel TOKAY Nesrin HOKELEK Tuncer | 2008 | Structural Chemistry2008，19，4： | 1 |
| 15 | Pulmonary Blastoma: A case report and review of the literature显示文摘 | Karcioglu Zeynel A Someren Ayten O | 1974 | Am J Clin pathol1974，61，： | 1 |
| 16 | 眼锌的功能显示文摘 | Zeynel A.Karcioglu 金永祺 | 1983 | 眼科新进展1983，，03： | 1 |
| 17 | 眼锌的功能显示文摘 | Zeynel A.Karcioglu 金永祺 | 1983 | 眼科新进展1983，，03： | 1 |
| 18 | 眼锌的功能显示文摘 | Zeynel A.Karcioglu 金永祺 | 1983 | 眼科新进展1983，，03： | 1 |
| 19 | Congenital Portal Vein Aneurysm Associated with Peliosis Hepatis and Intestinal Lymphangiectasia显示文摘 | Zeynel Mungan Binnur Pinarbasi Baris Bakir Mine Gulluoglu Bulent Baran Filiz Akyuz Kadir Demir Sabahattin Kaymakoglu Juan G. Abraldes | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
| 20 | Response to Hepatitis B Vaccination in Patients with Celiac Disease显示文摘 | Emel Ahishali Gungor Boztas Filiz Akyuz Duygu Ibrisim Sule Poturoglu Binnur Pinarbasi Sadakat Ozdil Zeynel Mungan | 2008 | Digestive Diseases and Sciences2008，，8： | 1 |
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