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| 1 | Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants显示文摘AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF survival and overall survival. Among patients received CRT, overall survival was significantly longer in patients with negative than positive surgical margin(27.7 mo vs 22.4 mo, P = 0.016) in the overallstudy population, while time of radiotherapy initiation had no significant impact on survival times. Nodal stage was determined to be independent predictor of LRF survival in the overall study population with 4.959 fold(P = 0.042) increase in mortality in patients with nodal stage N2 compared to patients with nodal stage N0, and independent predictor of overall survival with 5.132 fold(P = 0.006), 5.263 fold(P = 0.027) and 4.056 fold(P = 0.009) increase in the mortality in patients with nodal stage N3a(before 2008), N3b(before 2008) and N2(overall study population) when compared to patients with N0 stage, respectively.CONCLUSION: Our findings emphasize the likelihood of postoperative adjuvant CRT to have a survival benefit in patients with resectable gastric carcinoma. | Sevgi Ozden Zerrin Ozgen Hazan Ozyurt Cengiz Gemici Gokhan Yaprak Huseyin Tepetam Alpaslan Mayadagli | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 4 | Is the severity of obstructive sleep apnea or the magnitude of respiratory effort associated with gastroesophageal reflux?显示文摘TO THE EDITOR
In a tecent issue of World Journal of Gastroenterology,Demeter et al.[1],reported that in patients having both gastro-esophageal reflux disease(GERD)and obstructive sleep apnea(OSA),there was a positive correlation between endoscopic findings of GERD and the number of apneas and hypopneas per hour,namely apnea hypopnea index. | Levent Ozturk Zerrin Pelin | 2005 | World Journal of Gastroenterology2005，11，30： | 2 |
| 5 | Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia显示文摘 | Ay?enur Okten Ilke Mungan Mukaddes Kalyoncu Zerrin Orbak | 2007 | Clinical Rheumatology2007，，1： | 1 |
| 6 | Functional magnetic resonance imaging of the somatosensory cortex显示文摘 | WADE M MULLER F ZERRIN Y | 1997 | Neurosurgery Clinics of North America1997，8，： | 1 |
| 7 | Dispensing practice in the community pharmacies in the Turkish Republic of Northern Cyprus 显示文摘 | Laika GH Zerrin T | 2012 | Intemational Journal of Clinical Pharmacy2012，34，2： | 1 |
| 8 | Chromosome heteromorphisms: an impact on infertility显示文摘 | Feride Iffet Sahin Zerrin Yilmaz Ozge Ozalp Yuregir Tugce Bulakbasi Ozge Ozer Hulusi Bulent Zeyneloglu | 2008 | Journal of Assisted Reproduction and Genetics2008，，： | 1 |
| 9 | Difference in avB3 integrin expression in endometrial stromal cell in subgroups of women with unexplained infertility显示文摘 | Nuri C Semih K Zerrin C | 2006 | Eur J Obstet Gynecol Reprod Biol2006，126，2： | 1 |
| 10 | Visualization of the distal intratemporal MR imaging:use of an oblique plane显示文摘 | Leighton P Mark MD Zerrin Y | 1992 | Radiology1992，182，： | 1 |
| 11 | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori -Positive and -Negative Patients and Its Effect on Anemia显示文摘 | Ya?ar Do?an Tülay Erkan Zerrin ?nal Merve Usta Gülen Do?usoy Fügen ?ullu ?oku?ra? Tufan Kutlu Helieh S. Oz | 2012 | Mediators of Inflammation2012，，： | 1 |
| 12 | Anaerobic treatment of potato processing wastewater显示文摘 | GEORGE R ZOUTBERG ZERRIN EKER | 1999 | Water Science and Technology1999，40，1： | 1 |
| 13 | Anaerobic treatment of potato processing wastewater 显示文摘 | George R Zoutberg Zerrin Eker | 1999 | Water Sci Technol1999，40，1： | 1 |
| 14 | Optical,structural and bonding properties of diamond-like amorphous carbon films deposited by DC magnetron sputtering显示文摘 | CO?KUN ? D ZERRIN T | 2015 | Diamond and Related Materials2015，56，： | 1 |
| 15 | Lipid peroxidation and paraoxonase activity in nocturnal cyclic and sustained intermittent hypoxia显示文摘 | Hacer Kuzu Okur Zerrin Pelin Meral Yuksel Sebnem Yosunkaya | 2013 | Sleep and Breathing2013，，1： | 1 |
| 16 | Difference in αvβ3 integrin expression in endometrial stromal cell in subgroups of women with unexplained infertility显示文摘 | NURI C SEMIH K ZERRIN C | 2006 | Eur J Obstet Gynecol Reprod Biol2006，126，2： | 1 |
| 17 | FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer’s disease显示文摘 | F. Zerrin Yetkin Roger N. Rosenberg Myron F. Weiner Phillip D. Purdy C. Munro Cullum | 2006 | European Radiology2006，，1： | 1 |
| 18 | An approach for energy conscious renovation of residential buildings in Istanbul by Trombe wall system 显示文摘 | Zerrin Y B K Arch | 2008 | Building and Environment2008，43，： | 1 |
| 19 | Use of functional MR to map language in multilingual volunteers 显示文摘 | Yetkin O Zerrin Yetkin F Haughton V M | 1996 | Ameri- can Journal of Neuroradiology1996，，17： | 1 |
| 20 | The efficacy of cystatin C assay in the prediction of glomerular filtration rate. Is it a more reliable marker for renal failure?显示文摘 | Zerrin Bicik Talat Bahcebasi Sevsen Kulaks?zoglu Ozlem Yavuz | 2005 | Clinical Chemical Laboratory Medicine2005，，8： | 1 |
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