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| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | 缺血性间歇性阴茎异常勃起的药物治疗:当前的文献综述显示文摘阴茎异常勃起是指阴茎在没有受性刺激的情况下,发生的不自主的长时间勃起。目前,关于这种异常勃起的病理生理学信息很少,所以我们对此疾病也知之甚少。这种不可逆的勃起伤害以及导致的勃起功能障碍使这种疾病的并发症也很可怕。间歇性阴茎异常勃起尽管很少见,但在镰状细胞疾病(SCD)患者中发生率很高,而且也迫切需要制定指南来治疗这些病人的勃起功能问题。因为对这种疾病的发病机制不是很清楚,所以对泌尿外科医生来说,这种疾病的药物治疗也是一个极大的挑战。还需要更多的研究让我们可以有效确定这些病人的治疗方法,以预防作为最终目的。本综述主要介绍间歇性阴茎异常勃起疾病及其临床意义,尤其针对那些有SCD的病人。另外,还讨论该疾病可能的病理生理学机制,总结和讨论当前和将来的药物治疗策略。 | Helen R Levey Omer Kutlu Trinity J Bivalacqua | 2012 | Asian Journal of Andrology2012，14，1： | 5 |
| 3 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 4 | Renoportal anastomosis in living donor liver transplantation with prior proximal splenorenal shunt显示文摘For transplant surgeons, end-stage liver disease with portal venous thrombosis and a previous splenorenal shunt(SRS) is a significant challenge during liver transplantation. Thrombosis of the portal vein can be corrected by surgical interventions, such as portal venous thrombectomy or surgical removal of the thrombosed portal vein. Even also placement of a graft between the mesenteric vein and the graft portal vein can be performed. If these maneuvers fail, a renoportal anastomosis(RPA) can be performed to achieve adequate graft inflow. A 51-year-old male patient who had a history of proximal SRS and splenectomy underwent living donor liver transplantation(LDLT) due to cryptogenic cirrhosis. LDLT was performed with RPA using a cadaveric iliac vein graft. The early postoperative course of the patient was completely uneventful and he was discharged 20 d after transplantation. To the best of our knowledge, this was the first patient to receive LDLT with RPA after surgical proximal SRS and splenectomy. | Fatih Ozdemir Koray Kutluturk Bora Barut Perviz Abbasov Ramazan Kutlu Cuneyt Kayaalp Sezai Y?lmaz | 2017 | World Journal of Transplantation2017，7，1： | 2 |
| 5 | Preparation and investigation of the combustion behavior of polypropylene/organomodified MgAl-LDH micro-nanocomposite显示文摘 | De-Yi Wang Andreas Leuteritz Burak Kutlu Maria Auf der Landwehr Dieter Jehnichen Udo Wagenknecht Gert Heinrich | 2010 | Journal of Alloys and Compounds2010，，8： | 2 |
| 6 | Antibiotic prophylaxis in elective thoracic surgery: cefuroxime versus ce fepime 显示文摘 | Turna A Kutlu C A Ozalp T | 2003 | Thorac Cardiovasc Surg2003，51，2： | 2 |
| 7 | Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic β-cells显示文摘 | Kutlu B Darville MI Cardozo AK | 2003 | Diabetes2003，52，： | 1 |
| 8 | The relationship between the concha bullosa,nasal septal deviation and sinusitis显示文摘 | Aktas D Kalcioglu MT Kutlu R | 2003 | Rhinology2003，41，2： | 1 |
| 9 | Peripheral neuropa- thy and visual evoked potential changes in workers exposed to n-hexane显示文摘 | KUTLU G GOMCELI Y B SONMEZ T | 2009 | J Clin Neurosei2009，16，10： | 1 |
| 10 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Ficicioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 11 | Differences in the cellular and humoral immune system between middle-aged men with different intensity and duration of physically training显示文摘 | Buyukyazi G Kutukculer N Kutlu N | 2004 | J Sports Med Phys Fitness2004，44，2： | 1 |
| 12 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Figicioglu C Kutlu T Demirbasoqlu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 13 | Estimating specificsurface area and cation exchange capacity in soils using fractaldimension of particle - size distribution 显示文摘 | ERSAHINS’GUNAL H KUTLU T | 2006 | Geoderma2006，136，34： | 1 |
| 14 | Shoulder-girdle strength after standard and lateral muscle-sparing thoracotomy显示文摘 | KUTLU CA AKIN H OLCMEN A | 2001 | Thorac Cardiovasc Surg2001，49，2： | 1 |
| 15 | Early follicular anti-Mullerian hormone as an indicator of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Baglam E | 2006 | Fertil Steril2006，85，3： | 1 |
| 16 | Chylothorax: a complication fol-lowing lung resection in patients with NSCLC-chylothorax followinglung resection显示文摘 | Kutlu CA Sayar A Olgac G | 2003 | Thorac Cardiovasc Surg2003，51，6： | 1 |
| 17 | Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane显示文摘 | Kutlu G Gomceli Y B Sonmez T | 2009 | J Clin Neurosci2009，16，10： | 1 |
| 18 | The role of inhibin B as a basal determinant of ovarian reserve显示文摘 | Ficicioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endocrinol2003，17，4： | 1 |
| 19 | Serum nerve growth factor levels in autistic children in Turkish population:apreliminary study显示文摘 | Dinel N nalp A Kutlu A | 2013 | Indian J Med Res2013，138，6： | 1 |
| 20 | The role of inhibin B as a basal determinant of ovarian reserve 显示文摘 | Ficieioglu C Kutlu T Demirbasoglu S | 2003 | Gynecol Endecrinol2003，17，4： | 1 |
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