|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD44与大肠癌关系的研究进展显示文摘大肠癌是消化系统中常见的恶性肿瘤,其发病率呈逐年上升趋势。癌的侵袭和转移是引起癌症患者死亡的主要原因。肿瘤转移过程需要细胞与细胞外间质或与其他细胞的一系列相互作用,其中肿瘤细胞表面的黏附分子在肿瘤侵袭和转移中起着极为重要的作用,如CD44,该分子作为透明质酸的受体,直接影响到肿瘤细胞与细胞外基质的结合能力,进而影响肿瘤的侵袭和转移。通过选择性剪接形成可将CD44分为10种剪接变异体(CD44v)。研究认为,v6外显子的变异体-CD44v6与细胞的运动、大肠肿瘤的发生、发展和侵袭、转移行为密切相关。 | 熊兵红 程勇 | 2007 | 中华肿瘤防治杂志2007，14，2： | 15 |
| 2 | Lipid peroxidation and antioxidant status in colorectal cancer显示文摘AIM: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Both enzymatic and non-enzymatic parameters participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of final lipid peroxidation products like malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) in primary colorectal cancer. Moreover, we analysed the activity of main antioxidative enzymes, superoxide dismutase (Cu, Zn-SOD),catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSRG-R) and the level of nonenzymatic antioxidants (glutathione, vitamins C and E).METHODS: Investigations were conducted in 81 primary colorectal cancers. As a control, the same amount of sample was collected from macroscopically unchanged colon regions of the most distant location to the cancer.Homogenisation of specimens provided 10% homogenates for our evaluations. Activity of antioxidant enzymes and level of glutathione were determined by spectrophotometry.HPLC revealed levels of vitamins C and E and served as a method to detect terminal products of lipid peroxidation in colorectal cancer.RESULTS: Our studies demonstrated a statistically significant increase in the level of lipid peroxidation products (MDA-Adc.muc.-2.65±0.48 nmol/g, Adc. G3-2.15±0.44 nmol/g, clinical Ⅳ stage 4.04±0.47 nmol/g, P<0.001 and 4-HNE-Adc.muc.-0.44±0.07 nmol/g, Adc. G3-0.44±0.10 nmol/g, clinical Ⅳstage 0.52±0.11 nmol/g, P<0.001) as well as increase of Cu,Zn-SOD (Adc.muc.-363±72 U/g, Adc. G3-318±48 U/g,clinical Ⅳ stage 421±58 U/g, P<0.001), GSH-Px (Adc.muc.-2143±623 U/g, Adc. G3-2005±591 U/g, clinical Ⅳ stage 2467±368 U/g, P<0.001) and GSSG-R (Adc. muc.-880±194 U/g,Adc. G3-795±228 U/g, dinical Ⅳ stage 951±243 U/g, P<0.001)in primary tumour comparison with normal colon (MDA1.39±0.15 nmol/g, HNE-0.29±0.03 nmol/g, Cu, Zn-SOD-117±25 U/g, GSH-Px-1723±189 U/g, GSSG-R-625±112 U/g)especially in mucinous and G3-grade adenocarcinomas as well as clinical Ⅳ stage of colorectal cancer. We also observed a decrease of CAT activity (Adc.muc. -40±14 U/g,clinical Ⅳ stage 33±18 U/g vs84±17 U/g, P<0.001) as well as a decreased level of reduced glutathione (clinical Ⅳ stage 150±48 nmol/g vs 167±15 nmol/g, P<0.05) and vitamins C and E (vit. C-clinical Ⅳ stage 325±92 nmol/g vs 513±64 nmol/g, P<0.001; vit. E-clinical Ⅳ stage 13.3±10.3nmol/g vs37.5±5.2 nmol/g).CONCLUSION: Colorectal carcinogenesis is associated with serious oxidative stress and confirms that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer. | Elzbieta Skrzydlewska Stanislaw Sulkowski Mariusz Koda Bogdan Zalewski Luiza Kanczuga-Koda Mariola Sulkowska | 2005 | World Journal of Gastroenterology2005，11，3： | 12 |
| 3 | Association of Catalase Genotype with Oxidative Stress in the Predication of Colorectal Cancer:Modification by Epidemiological Factors显示文摘Objective This paper aims to assess the interaction between common variations in catalase(CAT) polymorphic gene and environmental factors for antioxidant defense enzyme in modulating individual susceptibility to colorectal cancer(CRC).Methods A case-control study with 880 colorectal cancer cases and 848 controls was conducted to investigate whether variations in the catalase(CAT) gene,one of the genes involved in scavenging oxidative stress,influenced susceptibility to CRC.Results The interaction between life style and genotypes as well as with their effects on colorectal cancer was deduced from the present study.Significant difference(P=0.01) was identified in the distribution of CAT genotype between the colorectal cancer cases and the controls.The CRC cases had significantly lower mean activity than the controls(P<0.01).Correlation analyses revealed statistically significant correlations between CAT activity and CAT genotype(P<0.01).Conclusion The risk of CRC was associated with smoking,low vegetable consumption,high pork and poultry consumptions,and low or high BMI.This is the first study reporting an association of polymorphism CAT-21A>T with colorectal cancer.Low CAT activity was associated with an increased risk of CRC;however,no evidence was found to support an association between CAT-21A>T polymorphism and CRC risk. | CHANG Dong HU Zhang Liang ZHANG Lin ZHAO Ya Shuang MENG Qing Hui GUAN Qing Bai ZHOU Jin PAN Hong Zhi | 2012 | Biomedical and Environmental Sciences2012，25，2： | 2 |
| 4 | NM23-H1、CD44v6在无淋巴结转移非小细胞肺癌中的表达及临床意义显示文摘[目的]探讨NM23-H1、CD44v6在无淋巴结转移的非小细胞肺癌(N0 NSCLC)中的表达及其临床意义。[方法]应用免疫组织化学的方法检测60例手术后病理证实N0NSCLC组织NM23-H1、CD44v6的表达,分析其表达与患者术后5年预后的关系。[结果]NM23-H1及CD44v6的表达在鳞癌与腺癌间差异均无显著性意义;NM23-H1阳性表达与患者5年预后呈正相关(r=0.887),CD44v6阳性表达与患者5年预后呈负相关(r=-0.784)。[结论]癌组织NM23-H1、CD44v6的表达可作为评估N0 NSCLC患者预后的指标。 | 魏明超 岳世昌 王齐敏 王乃玉 | 2011 | 大连医科大学学报2011，33，5： | 2 |
| 5 | 外周血肿瘤标志物检测进展显示文摘外周血肿瘤标志物检测是临床常用的肿瘤诊断及预后判断的方法,近年在外周血中发现了许多新的肿瘤标志物。合理的选择性的应用这些肿瘤标志物可以进行某些肿瘤的早期诊断,更准确地进行临床分期,帮助制定更合理的治疗方案,进行预后的判定等。外周血中肿瘤标志物的检测具有重要的临床意义。 | 张峻青 张贺龙 | 2005 | 现代肿瘤医学2005，13，6： | 2 |
| 6 | NM23基因/NDPK、CD44v6蛋白表达在非小细胞肺癌中的临床意义显示文摘肺癌分为非小细胞肺癌(NSCLC)和小细胞肺癌(SCLC)两大类,其中NSCLC约占80%以上。目前肺癌总的5年生存率只有15%左右,90%以上患者死于肺瘤侵袭和转移的相关并发症。侵袭和转移是恶性肿瘤的两个最主要的生物学特征和标志,近年来研究发现了与肿瘤转移呈正负相关的肿瘤转移相关基因和肿瘤转移抑制相关基因,前者的激活和(或)后者的失活能促进或导致肿瘤转移的发生。许多分子生物学标记与肺癌的预后密切相关,可以提示复发和转移的倾向。因此在NSCLC中检测nm23基因/NDPK及CD44v6的表达,对判断预后,预防及治疗NSCLC侵袭和转移将提供有效的途径,形成治疗的生物靶点等方面,均具有重要意义。 | 帕提古丽.阿尔西丁 张国庆 马玲 | 2008 | 现代医药卫生2008，24，20： | 1 |
| 7 | CD44与大肠癌研究的进展显示文摘CD44与细胞的运动、肿瘤的发生、浸润和转移关系密切,与胃肠道肿瘤关系的研究已受到普遍关注。笔者综述近年关于CD44在大肠癌中的异常表达的有关文献,阐明其与肿瘤发生、发展、浸润、转移的关系,及其在大肠癌诊断和预后判断中的意义。 | 熊兵红 程勇 | 2007 | 中国普通外科杂志2007，16，7： | 1 |
| 8 | 选择性剪接与大肠癌关系的研究进展显示文摘大肠癌是世界范围内最常见的恶性肿瘤之一,其发病率和病死率呈逐年上升趋势,中国大城市的大肠癌发生率已居恶性肿瘤的第2~3位。由于早期缺乏临床症状或症状不典型,大肠癌不易被早期发现, | 赵一军 杨俊 | 2014 | 上海医学2014，37，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员