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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | 前房注射头孢呋辛对术后眼内炎的预防作用(英文)显示文摘目的:研究前房注射头孢呋辛对术后眼内炎的预防作用。方法:回顾性研究6 099例行超声乳化白内障手术的年龄相关性白内障患者。对照组,2001-10/2004-05,3 075例3 075眼行白内障手术未用眼内抗生素,实验组,2004-06/2007-04,3 024例3 024眼术中前房用0.1mL含1mg的头孢呋辛。两组的术前预防措施和手术步骤相同。结果:对照组和实验组分别有13(0.42%)和4(0.13%)例患者发生术后眼内炎[P=0.031;OR =3.20(1.04-9.84)]。两组发生术后眼内炎的平均时间分别是术后30(3 ~75)d和25(2 ~35)d(P=0.35)。研究细菌感染,实验组,烟曲菌和铜绿假单胞菌对头孢呋辛耐药,而肺炎链球菌对头孢呋辛敏感。未发现前房运用头孢呋辛的毒性和过敏性症状。结论:预防性前房运用头孢呋辛是安全的,可以预防术后细菌性眼内炎。然而抗生素抗菌谱窄和抗生素耐药性的可能性需要考虑。 | Güngr Sobaci Yusuf Uysal Fatih M Mutlu Atilla Bayer Rιza Gungor Suat Karagul | 2009 | 国际眼科杂志2009，9，8： | 2 |
| 4 | Research on the additional stress and deformation in the soil of compo-site pile foundation under vertically uniform loads显示文摘 | Yu C Za J M Liu S Y | 2005 | Advances in Deep Foundations(GSP132)2005，，157： | 1 |
| 5 | Isoformselective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia:a novel therapeutic approach显示文摘 | Niedermeier M Hennessy BT Knight ZA | 2009 | Blood2009，113，22： | 1 |
| 6 | Prevalence of MERS- CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj 显示文摘 | Memish ZA Assiri A Almasri M | 2014 | J Infect Dis2014，210，7： | 1 |
| 7 | Knnwlcdgc, practi~:e,atld at- tiLude among Iranian nurses,midwives,and sLudcnts regarding standard isolation preeautions显示文摘 | Askarian M Memish ZA Khan AA | 2007 | lnfect Conlrol Hosp Epidemi- nl2007，28，2： | 1 |
| 8 | Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis显示文摘 | Jenkins ZA van Kogelenberg M Morgan T | 2009 | Nature Genetics2009，41，1： | 1 |
| 9 | Online voltage stability monitoring显示文摘 | DE SOU ZA A C Z DE SOUZA J C S DA SILVA A M L | 2000 | IEEE Trans on Power Systems2000，15，4： | 1 |
| 10 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 11 | Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infec- tion: a retrospective cohort study 显示文摘 | Omrani AS Saad MM Baig K Bahloul A Abdul-Matin M Alaidaroos AY Almakhlafi GA Albarrak MM Mem- ish ZA Albarrak AM | 2014 | Lancet Infect Dis2014，14，11： | 1 |
| 12 | Germline mutations in WTX cause a sclerasing skeletal dysplasia but do not predispose to tumorigenesis显示文摘 | Jenkins ZA ' 'an Kogelenberg M Morgan T | 2009 | Nat Genet2009，41，1： | 1 |
| 13 | Th e Nl r p 3inflammasome:contributions to intestinal homeostasis显示文摘 | Za k i MH L amk a n f i M Ka n n e g a n t i TD | 2011 | Trends Immunol2011，32，4： | 1 |
| 14 | Community case clusters of Middle East Respiratory Syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study 显示文摘 | Memish ZA Cotten M Watson S J | 2014 | Int J Infect Dis2014，23，： | 1 |
| 15 | Laboratory aspects of asymptomatic bacteriuria after operation 显示文摘 | Mohammad M Mahdy ZA Omar J | 2002 | Southeast Asian J Trop Med Public Health2002，33，3： | 1 |
| 16 | Dimensions of the anterior tarsal tunnel and features of the deep peroneal nerve in relation to clinical application显示文摘 | Ikiz ZA Ucerler H Uygur M | 2007 | Surg Radiol Anat2007，29，7： | 1 |
| 17 | Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE):a randomised clinical trial显示文摘 | Fayad ZA Mani V Woodward M | 2011 | Lancet2011，378，9802： | 1 |
| 18 | Real-time nonlinear finite element analysis for surgical simulation using graphics processing units显示文摘 | Taylor ZA Cheng M Ourselin S | 2007 | Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv2007，10，1： | 1 |
| 19 | Memantine for axonal loss of optic neuritis显示文摘 | Esfahani MR Harandi ZA Movasat M | 2012 | Graefes Arch Clin Exp Ophthalmol2012，250，6： | 1 |
| 20 | The contraceptive potential of ZP3 and ZP3 peptides in a primate model显示文摘 | Paterson M Jennings ZA Wilson MR | 2002 | J Reprod Immunol2002，53，12： | 1 |
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